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DCX (doublecortin)

Identity

Alias_namesdoublecortex
Alias_symbol (synonym)SCLH
DC
LISX
DBCN
XLIS
Other alias
HGNC (Hugo) DCX
LocusID (NCBI) 1641
Atlas_Id 45751
Location Xq23  [Link to chromosome band Xq23]
Location_base_pair Starts at 110537007 and ends at 110654374 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CAPN6 (Xq23) / DCX (Xq23)DCX (Xq23) / PASD1 (Xq28)ZNF785 (16p11.2) / DCX (Xq23)
CAPN6 Xq23 / DCX Xq23DCX Xq23 / PASD1 Xq28

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCX   2714
Cards
Entrez_Gene (NCBI)DCX  1641  doublecortin
AliasesDBCN; DC; LISX; SCLH; 
XLIS
GeneCards (Weizmann)DCX
Ensembl hg19 (Hinxton)ENSG00000077279 [Gene_View]  chrX:110537007-110654374 [Contig_View]  DCX [Vega]
Ensembl hg38 (Hinxton)ENSG00000077279 [Gene_View]  chrX:110537007-110654374 [Contig_View]  DCX [Vega]
ICGC DataPortalENSG00000077279
TCGA cBioPortalDCX
AceView (NCBI)DCX
Genatlas (Paris)DCX
WikiGenes1641
SOURCE (Princeton)DCX
Genetics Home Reference (NIH)DCX
Genomic and cartography
GoldenPath hg19 (UCSC)DCX  -     chrX:110537007-110654374 -  Xq23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DCX  -     Xq23   [Description]    (hg38-Dec_2013)
EnsemblDCX - Xq23 [CytoView hg19]  DCX - Xq23 [CytoView hg38]
Mapping of homologs : NCBIDCX [Mapview hg19]  DCX [Mapview hg38]
OMIM300067   300121   
Gene and transcription
Genbank (Entrez)AF034634 AF040254 AF040255 AJ003112 AK002120
RefSeq transcript (Entrez)NM_000555 NM_001195553 NM_178151 NM_178152 NM_178153
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_011750 NT_011651 NW_004929444
Consensus coding sequences : CCDS (NCBI)DCX
Cluster EST : UnigeneHs.34780 [ NCBI ]
CGAP (NCI)Hs.34780
Alternative Splicing GalleryENSG00000077279
Gene ExpressionDCX [ NCBI-GEO ]   DCX [ EBI - ARRAY_EXPRESS ]   DCX [ SEEK ]   DCX [ MEM ]
Gene Expression Viewer (FireBrowse)DCX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1641
GTEX Portal (Tissue expression)DCX
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43602   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43602  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43602
Splice isoforms : SwissVarO43602
PhosPhoSitePlusO43602
Domaine pattern : Prosite (Expaxy)DC (PS50309)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Doublecortin_chordata    Doublecortin_dom   
Domain families : Pfam (Sanger)DCX (PF03607)   
Domain families : Pfam (NCBI)pfam03607   
Domain families : Smart (EMBL)DCX (SM00537)  
Conserved Domain (NCBI)DCX
DMDM Disease mutations1641
Blocks (Seattle)DCX
PDB (SRS)1MJD    2BQQ    2XRP    4ATU   
PDB (PDBSum)1MJD    2BQQ    2XRP    4ATU   
PDB (IMB)1MJD    2BQQ    2XRP    4ATU   
PDB (RSDB)1MJD    2BQQ    2XRP    4ATU   
Structural Biology KnowledgeBase1MJD    2BQQ    2XRP    4ATU   
SCOP (Structural Classification of Proteins)1MJD    2BQQ    2XRP    4ATU   
CATH (Classification of proteins structures)1MJD    2BQQ    2XRP    4ATU   
SuperfamilyO43602
Human Protein AtlasENSG00000077279
Peptide AtlasO43602
HPRD02127
IPIIPI00216744   IPI00220076   IPI00220077   IPI00220078   IPI00847840   IPI00946204   IPI00982341   IPI00945328   
Protein Interaction databases
DIP (DOE-UCLA)O43602
IntAct (EBI)O43602
FunCoupENSG00000077279
BioGRIDDCX
STRING (EMBL)DCX
ZODIACDCX
Ontologies - Pathways
QuickGOO43602
Ontology : AmiGOneuron migration  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  nucleus  cytoplasm  cytoplasm  cytosol  cytoskeleton  microtubule  microtubule associated complex  nervous system development  central nervous system development  microtubule binding  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  protein kinase binding  hippocampus development  layer formation in cerebral cortex  pyramidal neuron development  central nervous system projection neuron axonogenesis  dendrite  intracellular signal transduction  neuron projection  protein autophosphorylation  axon extension  dendrite morphogenesis  response to electrical stimulus  
Ontology : EGO-EBIneuron migration  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  nucleus  cytoplasm  cytoplasm  cytosol  cytoskeleton  microtubule  microtubule associated complex  nervous system development  central nervous system development  microtubule binding  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  protein kinase binding  hippocampus development  layer formation in cerebral cortex  pyramidal neuron development  central nervous system projection neuron axonogenesis  dendrite  intracellular signal transduction  neuron projection  protein autophosphorylation  axon extension  dendrite morphogenesis  response to electrical stimulus  
Pathways : BIOCARTALissencephaly gene (LIS1) in neuronal migration and development [Genes]   
NDEx NetworkDCX
Atlas of Cancer Signalling NetworkDCX
Wikipedia pathwaysDCX
Orthology - Evolution
OrthoDB1641
GeneTree (enSembl)ENSG00000077279
Phylogenetic Trees/Animal Genes : TreeFamDCX
HOVERGENO43602
HOGENOMO43602
Homologs : HomoloGeneDCX
Homology/Alignments : Family Browser (UCSC)DCX
Gene fusions - Rearrangements
Fusion: TCGACAPN6 Xq23 DCX Xq23 BRCA
Fusion: TCGADCX Xq23 PASD1 Xq28 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCX
dbVarDCX
ClinVarDCX
1000_GenomesDCX 
Exome Variant ServerDCX
ExAC (Exome Aggregation Consortium)DCX (select the gene name)
Genetic variants : HAPMAP1641
Genomic Variants (DGV)DCX [DGVbeta]
DECIPHER (Syndromes)X:110537007-110654374  ENSG00000077279
CONAN: Copy Number AnalysisDCX 
Mutations
ICGC Data PortalDCX 
TCGA Data PortalDCX 
Broad Tumor PortalDCX
OASIS PortalDCX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DCX
DgiDB (Drug Gene Interaction Database)DCX
DoCM (Curated mutations)DCX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCX (select a term)
intoGenDCX
Cancer3DDCX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300067    300121   
Orphanet2047    14369   
MedgenDCX
Genetic Testing Registry DCX
NextProtO43602 [Medical]
TSGene1641
GENETestsDCX
Huge Navigator DCX [HugePedia]
snp3D : Map Gene to Disease1641
BioCentury BCIQDCX
ClinGenDCX (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1641
Chemical/Pharm GKB GenePA27184
Clinical trialDCX
Miscellaneous
canSAR (ICR)DCX (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCX
EVEXDCX
GoPubMedDCX
iHOPDCX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:02:52 CET 2017

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