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DDAH2 (dimethylarginine dimethylaminohydrolase 2)

Identity

Other aliasDDAH
DDAHII
G6a
HEL-S-277
NG30
HGNC (Hugo) DDAH2
LocusID (NCBI) 23564
Atlas_Id 55719
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31694814 and ends at 31698042 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CTNND1 (11q12.1) / DDAH2 (6p21.33)DDAH2 (6p21.33) / BAG1 (9p13.3)DDAH2 (6p21.33) / TTC7B (14q32.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DDAH2   2716
Cards
Entrez_Gene (NCBI)DDAH2  23564  dimethylarginine dimethylaminohydrolase 2
AliasesDDAH; DDAHII; G6a; HEL-S-277; 
NG30
GeneCards (Weizmann)DDAH2
Ensembl hg19 (Hinxton)ENSG00000213722 [Gene_View]  chr6:31694814-31698042 [Contig_View]  DDAH2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000213722 [Gene_View]  chr6:31694814-31698042 [Contig_View]  DDAH2 [Vega]
ICGC DataPortalENSG00000213722
TCGA cBioPortalDDAH2
AceView (NCBI)DDAH2
Genatlas (Paris)DDAH2
WikiGenes23564
SOURCE (Princeton)DDAH2
Genetics Home Reference (NIH)DDAH2
Genomic and cartography
GoldenPath hg19 (UCSC)DDAH2  -     chr6:31694814-31698042 -  6p21.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DDAH2  -     6p21.33   [Description]    (hg38-Dec_2013)
EnsemblDDAH2 - 6p21.33 [CytoView hg19]  DDAH2 - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIDDAH2 [Mapview hg19]  DDAH2 [Mapview hg38]
OMIM604744   
Gene and transcription
Genbank (Entrez)AA297871 AF070667 AF087894 AK026191 AK098671
RefSeq transcript (Entrez)NM_001303007 NM_001303008 NM_013974
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_007592 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249 NW_004929326
Consensus coding sequences : CCDS (NCBI)DDAH2
Cluster EST : UnigeneHs.247362 [ NCBI ]
CGAP (NCI)Hs.247362
Alternative Splicing GalleryENSG00000213722
Gene ExpressionDDAH2 [ NCBI-GEO ]   DDAH2 [ EBI - ARRAY_EXPRESS ]   DDAH2 [ SEEK ]   DDAH2 [ MEM ]
Gene Expression Viewer (FireBrowse)DDAH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23564
GTEX Portal (Tissue expression)DDAH2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95865   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95865  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95865
Splice isoforms : SwissVarO95865
Catalytic activity : Enzyme3.5.3.18 [ Enzyme-Expasy ]   3.5.3.183.5.3.18 [ IntEnz-EBI ]   3.5.3.18 [ BRENDA ]   3.5.3.18 [ KEGG ]   
PhosPhoSitePlusO95865
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DDAH2
DMDM Disease mutations23564
Blocks (Seattle)DDAH2
SuperfamilyO95865
Human Protein AtlasENSG00000213722
Peptide AtlasO95865
HPRD09204
IPIIPI00000760   IPI00647695   IPI00646524   IPI00645821   IPI00797462   
Protein Interaction databases
DIP (DOE-UCLA)O95865
IntAct (EBI)O95865
FunCoupENSG00000213722
BioGRIDDDAH2
STRING (EMBL)DDAH2
ZODIACDDAH2
Ontologies - Pathways
QuickGOO95865
Ontology : AmiGOcitrulline metabolic process  catalytic activity  protein binding  cytoplasm  mitochondrion  centrosome  cytosol  arginine catabolic process  nitric oxide biosynthetic process  nitric oxide mediated signal transduction  dimethylargininase activity  dimethylargininase activity  amino acid binding  negative regulation of apoptotic process  positive regulation of nitric oxide biosynthetic process  regulation of nitric-oxide synthase activity  extracellular exosome  
Ontology : EGO-EBIcitrulline metabolic process  catalytic activity  protein binding  cytoplasm  mitochondrion  centrosome  cytosol  arginine catabolic process  nitric oxide biosynthetic process  nitric oxide mediated signal transduction  dimethylargininase activity  dimethylargininase activity  amino acid binding  negative regulation of apoptotic process  positive regulation of nitric oxide biosynthetic process  regulation of nitric-oxide synthase activity  extracellular exosome  
NDEx NetworkDDAH2
Atlas of Cancer Signalling NetworkDDAH2
Wikipedia pathwaysDDAH2
Orthology - Evolution
OrthoDB23564
GeneTree (enSembl)ENSG00000213722
Phylogenetic Trees/Animal Genes : TreeFamDDAH2
HOVERGENO95865
HOGENOMO95865
Homologs : HomoloGeneDDAH2
Homology/Alignments : Family Browser (UCSC)DDAH2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDAH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDAH2
dbVarDDAH2
ClinVarDDAH2
1000_GenomesDDAH2 
Exome Variant ServerDDAH2
ExAC (Exome Aggregation Consortium)DDAH2 (select the gene name)
Genetic variants : HAPMAP23564
Genomic Variants (DGV)DDAH2 [DGVbeta]
DECIPHER (Syndromes)6:31694814-31698042  ENSG00000213722
CONAN: Copy Number AnalysisDDAH2 
Mutations
ICGC Data PortalDDAH2 
TCGA Data PortalDDAH2 
Broad Tumor PortalDDAH2
OASIS PortalDDAH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDAH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDAH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDAH2
DgiDB (Drug Gene Interaction Database)DDAH2
DoCM (Curated mutations)DDAH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDAH2 (select a term)
intoGenDDAH2
Cancer3DDDAH2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604744   
Orphanet
MedgenDDAH2
Genetic Testing Registry DDAH2
NextProtO95865 [Medical]
TSGene23564
GENETestsDDAH2
Huge Navigator DDAH2 [HugePedia]
snp3D : Map Gene to Disease23564
BioCentury BCIQDDAH2
ClinGenDDAH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23564
Chemical/Pharm GKB GenePA27186
Clinical trialDDAH2
Miscellaneous
canSAR (ICR)DDAH2 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDAH2
EVEXDDAH2
GoPubMedDDAH2
iHOPDDAH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:58:33 CEST 2017

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