Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DDR2 (discoidin domain receptor tyrosine kinase 2)

Identity

Alias_namesTYRO10
NTRKR3
discoidin domain receptor family
Alias_symbol (synonym)TKT
Other aliasMIG20a
HGNC (Hugo) DDR2
LocusID (NCBI) 4921
Atlas_Id 40281
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 162632438 and ends at 162780457 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DDR2 (1q23.3) / FMO4 (1q24.3)DDR2 (1q23.3) / GAB1 (4q31.21)KDM2A (11q13.2) / DDR2 (1q23.3)
TRABD (22q13.33) / DDR2 (1q23.3)UHMK1 (1q23.3) / DDR2 (1q23.3)DDR2 1q23.3 / FMO4 1q24.3
DDR2 1q23.3 / GAB1 4q31.21KDM2A 11q13.2 / DDR2 1q23.3TRABD 22q13.33 / DDR2 1q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)DDR2   2731
Cards
Entrez_Gene (NCBI)DDR2  4921  discoidin domain receptor tyrosine kinase 2
AliasesMIG20a; NTRKR3; TKT; TYRO10
GeneCards (Weizmann)DDR2
Ensembl hg19 (Hinxton)ENSG00000162733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162733 [Gene_View]  chr1:162632438-162780457 [Contig_View]  DDR2 [Vega]
ICGC DataPortalENSG00000162733
TCGA cBioPortalDDR2
AceView (NCBI)DDR2
Genatlas (Paris)DDR2
WikiGenes4921
SOURCE (Princeton)DDR2
Genetics Home Reference (NIH)DDR2
Genomic and cartography
GoldenPath hg38 (UCSC)DDR2  -     chr1:162632438-162780457 +  1q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDR2  -     1q23.3   [Description]    (hg19-Feb_2009)
EnsemblDDR2 - 1q23.3 [CytoView hg19]  DDR2 - 1q23.3 [CytoView hg38]
Mapping of homologs : NCBIDDR2 [Mapview hg19]  DDR2 [Mapview hg38]
OMIM191311   271665   
Gene and transcription
Genbank (Entrez)AA148473 AF268386 AK058006 AK092374 AK093865
RefSeq transcript (Entrez)NM_001014796 NM_006182
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDR2
Cluster EST : UnigeneHs.593833 [ NCBI ]
CGAP (NCI)Hs.593833
Alternative Splicing GalleryENSG00000162733
Gene ExpressionDDR2 [ NCBI-GEO ]   DDR2 [ EBI - ARRAY_EXPRESS ]   DDR2 [ SEEK ]   DDR2 [ MEM ]
Gene Expression Viewer (FireBrowse)DDR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4921
GTEX Portal (Tissue expression)DDR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16832   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16832  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16832
Splice isoforms : SwissVarQ16832
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusQ16832
Domaine pattern : Prosite (Expaxy)FA58C_1 (PS01285)    FA58C_2 (PS01286)    FA58C_3 (PS50022)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)DDR2    FA58C    Galactose-bd-like    Kinase-like_dom    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_rcpt_2_CS   
Domain families : Pfam (Sanger)F5_F8_type_C (PF00754)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam00754    pfam07714   
Domain families : Smart (EMBL)FA58C (SM00231)  TyrKc (SM00219)  
Conserved Domain (NCBI)DDR2
DMDM Disease mutations4921
Blocks (Seattle)DDR2
PDB (SRS)2WUH    2Z4F   
PDB (PDBSum)2WUH    2Z4F   
PDB (IMB)2WUH    2Z4F   
PDB (RSDB)2WUH    2Z4F   
Structural Biology KnowledgeBase2WUH    2Z4F   
SCOP (Structural Classification of Proteins)2WUH    2Z4F   
CATH (Classification of proteins structures)2WUH    2Z4F   
SuperfamilyQ16832
Human Protein AtlasENSG00000162733
Peptide AtlasQ16832
HPRD01868
IPIIPI00004409   IPI00553180   IPI00642640   IPI00643573   IPI00513916   IPI00556281   
Protein Interaction databases
DIP (DOE-UCLA)Q16832
IntAct (EBI)Q16832
FunCoupENSG00000162733
BioGRIDDDR2
STRING (EMBL)DDR2
ZODIACDDR2
Ontologies - Pathways
QuickGOQ16832
Ontology : AmiGOossification  endochondral bone growth  transmembrane receptor protein tyrosine kinase activity  protein binding  collagen binding  ATP binding  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  signal transduction  regulation of extracellular matrix disassembly  positive regulation of fibroblast migration  positive regulation of fibroblast migration  actin cytoskeleton  apical plasma membrane  peptidyl-tyrosine phosphorylation  extracellular matrix organization  collagen fibril organization  regulation of bone mineralization  biomineral tissue development  chondrocyte proliferation  chondrocyte proliferation  protein tyrosine kinase collagen receptor activity  collagen-activated tyrosine kinase receptor signaling pathway  positive regulation of osteoblast differentiation  positive regulation of protein kinase activity  protein autophosphorylation  positive regulation of fibroblast proliferation  positive regulation of sequence-specific DNA binding transcription factor activity  extracellular exosome  positive regulation of extracellular matrix disassembly  
Ontology : EGO-EBIossification  endochondral bone growth  transmembrane receptor protein tyrosine kinase activity  protein binding  collagen binding  ATP binding  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  signal transduction  regulation of extracellular matrix disassembly  positive regulation of fibroblast migration  positive regulation of fibroblast migration  actin cytoskeleton  apical plasma membrane  peptidyl-tyrosine phosphorylation  extracellular matrix organization  collagen fibril organization  regulation of bone mineralization  biomineral tissue development  chondrocyte proliferation  chondrocyte proliferation  protein tyrosine kinase collagen receptor activity  collagen-activated tyrosine kinase receptor signaling pathway  positive regulation of osteoblast differentiation  positive regulation of protein kinase activity  protein autophosphorylation  positive regulation of fibroblast proliferation  positive regulation of sequence-specific DNA binding transcription factor activity  extracellular exosome  positive regulation of extracellular matrix disassembly  
NDEx NetworkDDR2
Atlas of Cancer Signalling NetworkDDR2
Wikipedia pathwaysDDR2
Orthology - Evolution
OrthoDB4921
GeneTree (enSembl)ENSG00000162733
Phylogenetic Trees/Animal Genes : TreeFamDDR2
HOVERGENQ16832
HOGENOMQ16832
Homologs : HomoloGeneDDR2
Homology/Alignments : Family Browser (UCSC)DDR2
Gene fusions - Rearrangements
Fusion : MitelmanDDR2/FMO4 [1q23.3/1q24.3]  
Fusion : MitelmanDDR2/GAB1 [1q23.3/4q31.21]  [t(1;4)(q23;q31)]  
Fusion : MitelmanKDM2A/DDR2 [11q13.2/1q23.3]  [t(1;11)(q23;q13)]  
Fusion : MitelmanTRABD/DDR2 [22q13.33/1q23.3]  [t(1;22)(q23;q13)]  
Fusion : MitelmanUHMK1/DDR2 [1q23.3/1q23.3]  [t(1;1)(q23;q23)]  
Fusion: TCGADDR2 1q23.3 FMO4 1q24.3 SKCM
Fusion: TCGADDR2 1q23.3 GAB1 4q31.21 BRCA
Fusion: TCGAKDM2A 11q13.2 DDR2 1q23.3 LUAD
Fusion: TCGATRABD 22q13.33 DDR2 1q23.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDR2
dbVarDDR2
ClinVarDDR2
1000_GenomesDDR2 
Exome Variant ServerDDR2
ExAC (Exome Aggregation Consortium)DDR2 (select the gene name)
Genetic variants : HAPMAP4921
Genomic Variants (DGV)DDR2 [DGVbeta]
DECIPHERDDR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDR2 
Mutations
ICGC Data PortalDDR2 
TCGA Data PortalDDR2 
Broad Tumor PortalDDR2
OASIS PortalDDR2 [ Somatic mutations - Copy number]
Cancer Gene: CensusDDR2 
Somatic Mutations in Cancer : COSMICDDR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDR2
DgiDB (Drug Gene Interaction Database)DDR2
DoCM (Curated mutations)DDR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDR2 (select a term)
intoGenDDR2
Cancer3DDDR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191311    271665   
Orphanet12289   
MedgenDDR2
Genetic Testing Registry DDR2
NextProtQ16832 [Medical]
TSGene4921
GENETestsDDR2
Target ValidationDDR2
Huge Navigator DDR2 [HugePedia]
snp3D : Map Gene to Disease4921
BioCentury BCIQDDR2
ClinGenDDR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4921
Chemical/Pharm GKB GenePA27196
Clinical trialDDR2
Miscellaneous
canSAR (ICR)DDR2 (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDR2
EVEXDDR2
GoPubMedDDR2
iHOPDDR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:30:48 CEST 2017

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