DDR2 (discoidin domain receptor tyrosine kinase 2)

2003-02-01  

Identity

HGNC
DDR2
LOCATION
1q23.3
LOCUSID
4921
ALIAS
MIG20a,NTRKR3,TKT,TYRO10,WRCN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4921
MIM: 191311
HGNC: 2731
Ensembl: ENSG00000162733

Variants:

dbSNP: 4921
ClinVar: 4921
TCGA: ENSG00000162733
COSMIC: DDR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162733ENST00000367921Q16832
ENSG00000162733ENST00000367921A0A024R906
ENSG00000162733ENST00000367922Q16832
ENSG00000162733ENST00000367922A0A024R906
ENSG00000162733ENST00000415555Q5T244
ENSG00000162733ENST00000446985Q16832
ENSG00000162733ENST00000446985A0A024R906

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171

References

Pubmed IDYearTitleCitations
223289732011Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.180
236444672013The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.137
234014452013New targetable oncogenes in non-small-cell lung cancer.108
182019652008Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen.76
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172993902007Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma.51
151113042004Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis.47
243615282014Discoidin domain receptors in disease.44
177031882007Structural basis of the collagen-binding mode of discoidin domain receptor 2.37
168068672006The discoidin domain receptor DDR2 is a receptor for type X collagen.36

Citation

Dessen P

DDR2 (discoidin domain receptor tyrosine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40281/ddr2