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DDR2 (discoidin domain receptor tyrosine kinase 2)

Identity

Alias (NCBI)MIG20a
NTRKR3
TKT
TYRO10
WRCN
HGNC (Hugo) DDR2
HGNC Alias symbTKT
HGNC Previous nameTYRO10
 NTRKR3
HGNC Previous namediscoidin domain receptor family, member 2
LocusID (NCBI) 4921
Atlas_Id 40281
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 162632464 and ends at 162787405 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDR2 (1q23.3) / FMO4 (1q24.3)DDR2 (1q23.3) / GAB1 (4q31.21)KDM2A (11q13.2) / DDR2 (1q23.3)
TRABD (22q13.33) / DDR2 (1q23.3)UHMK1 (1q23.3) / DDR2 (1q23.3)DDR2 1q23.3 / FMO4 1q24.3
DDR2 1q23.3 / GAB1 4q31.21KDM2A 11q13.2 / DDR2 1q23.3TRABD 22q13.33 / DDR2 1q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DDR2   2731
Cards
Entrez_Gene (NCBI)DDR2    discoidin domain receptor tyrosine kinase 2
AliasesMIG20a; NTRKR3; TKT; TYRO10; 
WRCN
GeneCards (Weizmann)DDR2
Ensembl hg19 (Hinxton)ENSG00000162733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162733 [Gene_View]  ENSG00000162733 [Sequence]  chr1:162632464-162787405 [Contig_View]  DDR2 [Vega]
ICGC DataPortalENSG00000162733
TCGA cBioPortalDDR2
AceView (NCBI)DDR2
Genatlas (Paris)DDR2
SOURCE (Princeton)DDR2
Genetics Home Reference (NIH)DDR2
Genomic and cartography
GoldenPath hg38 (UCSC)DDR2  -     chr1:162632464-162787405 +  1q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDR2  -     1q23.3   [Description]    (hg19-Feb_2009)
GoldenPathDDR2 - 1q23.3 [CytoView hg19]  DDR2 - 1q23.3 [CytoView hg38]
ImmunoBaseENSG00000162733
Genome Data Viewer NCBIDDR2 [Mapview hg19]  
OMIM191311   271665   618175   
Gene and transcription
Genbank (Entrez)AA148473 AF268386 AK058006 AK092374 AK093865
RefSeq transcript (Entrez)NM_001014796 NM_001354982 NM_001354983 NM_006182
Consensus coding sequences : CCDS (NCBI)DDR2
Gene ExpressionDDR2 [ NCBI-GEO ]   DDR2 [ EBI - ARRAY_EXPRESS ]   DDR2 [ SEEK ]   DDR2 [ MEM ]
Gene Expression Viewer (FireBrowse)DDR2 [ Firebrowse - Broad ]
GenevisibleExpression of DDR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4921
GTEX Portal (Tissue expression)DDR2
Human Protein AtlasENSG00000162733-DDR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16832   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16832  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16832
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ16832
Domaine pattern : Prosite (Expaxy)FA58C_1 (PS01285)    FA58C_2 (PS01286)    FA58C_3 (PS50022)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)DDR1/DDR2    FA58C    Galactose-bd-like_sf    Kinase-like_dom_sf    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_rcpt_2_CS   
Domain families : Pfam (Sanger)F5_F8_type_C (PF00754)    PK_Tyr_Ser-Thr (PF07714)   
Domain families : Pfam (NCBI)pfam00754    pfam07714   
Domain families : Smart (EMBL)FA58C (SM00231)  TyrKc (SM00219)  
Conserved Domain (NCBI)DDR2
PDB (RSDB)2WUH    2Z4F    6FER   
PDB Europe2WUH    2Z4F    6FER   
PDB (PDBSum)2WUH    2Z4F    6FER   
PDB (IMB)2WUH    2Z4F    6FER   
Structural Biology KnowledgeBase2WUH    2Z4F    6FER   
SCOP (Structural Classification of Proteins)2WUH    2Z4F    6FER   
CATH (Classification of proteins structures)2WUH    2Z4F    6FER   
SuperfamilyQ16832
AlphaFold pdb e-kbQ16832   
Human Protein Atlas [tissue]ENSG00000162733-DDR2 [tissue]
HPRD01868
Protein Interaction databases
DIP (DOE-UCLA)Q16832
IntAct (EBI)Q16832
BioGRIDDDR2
STRING (EMBL)DDR2
ZODIACDDR2
Ontologies - Pathways
QuickGOQ16832
Ontology : AmiGOossification  endochondral bone growth  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  collagen binding  collagen binding  ATP binding  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  regulation of extracellular matrix disassembly  positive regulation of fibroblast migration  positive regulation of fibroblast migration  actin cytoskeleton  apical plasma membrane  peptidyl-tyrosine phosphorylation  extracellular matrix organization  collagen fibril organization  regulation of bone mineralization  biomineral tissue development  positive regulation of kinase activity  regulation of tissue remodeling  chondrocyte proliferation  chondrocyte proliferation  protein tyrosine kinase collagen receptor activity  protein tyrosine kinase collagen receptor activity  collagen-activated tyrosine kinase receptor signaling pathway  receptor complex  positive regulation of osteoblast differentiation  positive regulation of protein kinase activity  protein autophosphorylation  positive regulation of fibroblast proliferation  positive regulation of DNA-binding transcription factor activity  positive regulation of extracellular matrix disassembly  
Ontology : EGO-EBIossification  endochondral bone growth  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  collagen binding  collagen binding  ATP binding  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  regulation of extracellular matrix disassembly  positive regulation of fibroblast migration  positive regulation of fibroblast migration  actin cytoskeleton  apical plasma membrane  peptidyl-tyrosine phosphorylation  extracellular matrix organization  collagen fibril organization  regulation of bone mineralization  biomineral tissue development  positive regulation of kinase activity  regulation of tissue remodeling  chondrocyte proliferation  chondrocyte proliferation  protein tyrosine kinase collagen receptor activity  protein tyrosine kinase collagen receptor activity  collagen-activated tyrosine kinase receptor signaling pathway  receptor complex  positive regulation of osteoblast differentiation  positive regulation of protein kinase activity  protein autophosphorylation  positive regulation of fibroblast proliferation  positive regulation of DNA-binding transcription factor activity  positive regulation of extracellular matrix disassembly  
NDEx NetworkDDR2
Atlas of Cancer Signalling NetworkDDR2
Wikipedia pathwaysDDR2
Orthology - Evolution
OrthoDB4921
GeneTree (enSembl)ENSG00000162733
Phylogenetic Trees/Animal Genes : TreeFamDDR2
Homologs : HomoloGeneDDR2
Homology/Alignments : Family Browser (UCSC)DDR2
Gene fusions - Rearrangements
Fusion : MitelmanDDR2/FMO4 [1q23.3/1q24.3]  
Fusion : MitelmanDDR2/GAB1 [1q23.3/4q31.21]  
Fusion : MitelmanKDM2A/DDR2 [11q13.2/1q23.3]  
Fusion : MitelmanTRABD/DDR2 [22q13.33/1q23.3]  
Fusion : MitelmanUHMK1/DDR2 [1q23.3/1q23.3]  
Fusion : QuiverDDR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDR2
dbVarDDR2
ClinVarDDR2
MonarchDDR2
1000_GenomesDDR2 
Exome Variant ServerDDR2
GNOMAD BrowserENSG00000162733
Varsome BrowserDDR2
ACMGDDR2 variants
VarityQ16832
Genomic Variants (DGV)DDR2 [DGVbeta]
DECIPHERDDR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDR2 
Mutations
ICGC Data PortalDDR2 
TCGA Data PortalDDR2 
Broad Tumor PortalDDR2
OASIS PortalDDR2 [ Somatic mutations - Copy number]
Cancer Gene: CensusDDR2 
Somatic Mutations in Cancer : COSMICDDR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDR2
Mutations and Diseases : HGMDDDR2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDDR2
DgiDB (Drug Gene Interaction Database)DDR2
DoCM (Curated mutations)DDR2
CIViC (Clinical Interpretations of Variants in Cancer)DDR2
Cancer3DDDR2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191311    271665    618175   
Orphanet12289   
DisGeNETDDR2
MedgenDDR2
Genetic Testing Registry DDR2
NextProtQ16832 [Medical]
GENETestsDDR2
Target ValidationDDR2
Huge Navigator DDR2 [HugePedia]
ClinGenDDR2
Clinical trials, drugs, therapy
MyCancerGenomeDDR2
Protein Interactions : CTDDDR2
Pharm GKB GenePA27196
PharosQ16832
Clinical trialDDR2
Miscellaneous
canSAR (ICR)DDR2
HarmonizomeDDR2
DataMed IndexDDR2
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDDR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:06:20 CEST 2021

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