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DDT (D-dopachrome tautomerase)

Identity

Alias_symbol (synonym)DDCT
Other alias
HGNC (Hugo) DDT
LocusID (NCBI) 1652
Atlas_Id 40282
Location 22q11.23  [Link to chromosome band 22q11]
Location_base_pair Starts at 23971365 and ends at 23974491 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDT (22q11.23) / AKAP13 (15q25.3)DDT (22q11.23) / DDT (22q11.23)DIRC2 (3q21.1) / DDT (22q11.23)
IGFBP5 (2q35) / DDT (22q11.23)UNC13B (9p13.3) / DDT (22q11.23)DIRC2 3q21.1 / DDT 22q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DDT   2732
Cards
Entrez_Gene (NCBI)DDT  1652  D-dopachrome tautomerase
AliasesDDCT
GeneCards (Weizmann)DDT
Ensembl hg19 (Hinxton)ENSG00000099977 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099977 [Gene_View]  chr22:23971365-23974491 [Contig_View]  DDT [Vega]
ICGC DataPortalENSG00000099977
TCGA cBioPortalDDT
AceView (NCBI)DDT
Genatlas (Paris)DDT
WikiGenes1652
SOURCE (Princeton)DDT
Genetics Home Reference (NIH)DDT
Genomic and cartography
GoldenPath hg38 (UCSC)DDT  -     chr22:23971365-23974491 -  22q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDT  -     22q11.23   [Description]    (hg19-Feb_2009)
EnsemblDDT - 22q11.23 [CytoView hg19]  DDT - 22q11.23 [CytoView hg38]
Mapping of homologs : NCBIDDT [Mapview hg19]  DDT [Mapview hg38]
OMIM602750   
Gene and transcription
Genbank (Entrez)AK292044 BC005971 BC015508 BT006970 CA414359
RefSeq transcript (Entrez)NM_001084392 NM_001355
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_187633
Consensus coding sequences : CCDS (NCBI)DDT
Cluster EST : UnigeneHs.656723 [ NCBI ]
CGAP (NCI)Hs.656723
Alternative Splicing GalleryENSG00000099977
Gene ExpressionDDT [ NCBI-GEO ]   DDT [ EBI - ARRAY_EXPRESS ]   DDT [ SEEK ]   DDT [ MEM ]
Gene Expression Viewer (FireBrowse)DDT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1652
GTEX Portal (Tissue expression)DDT
Human Protein AtlasENSG00000099977-DDT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30046   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30046  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30046
Splice isoforms : SwissVarP30046
Catalytic activity : Enzyme4.1.1.84 [ Enzyme-Expasy ]   4.1.1.844.1.1.84 [ IntEnz-EBI ]   4.1.1.84 [ BRENDA ]   4.1.1.84 [ KEGG ]   
PhosPhoSitePlusP30046
Domaine pattern : Prosite (Expaxy)MIF (PS01158)   
Domains : Interpro (EBI)Macrophage_inhib_fac    Macrophage_inhib_fac_CS    Tautomerase/MIF_sf   
Domain families : Pfam (Sanger)MIF (PF01187)   
Domain families : Pfam (NCBI)pfam01187   
Domain structure : Prodom (Prabi Lyon)Macrophage_inhib_fac (PD004816)   
Conserved Domain (NCBI)DDT
DMDM Disease mutations1652
Blocks (Seattle)DDT
PDB (SRS)1DPT    3KAN    4Q3F   
PDB (PDBSum)1DPT    3KAN    4Q3F   
PDB (IMB)1DPT    3KAN    4Q3F   
PDB (RSDB)1DPT    3KAN    4Q3F   
Structural Biology KnowledgeBase1DPT    3KAN    4Q3F   
SCOP (Structural Classification of Proteins)1DPT    3KAN    4Q3F   
CATH (Classification of proteins structures)1DPT    3KAN    4Q3F   
SuperfamilyP30046
Human Protein Atlas [tissue]ENSG00000099977-DDT [tissue]
Peptide AtlasP30046
HPRD04126
IPIIPI00293867   IPI00878984   IPI00894562   IPI00894440   IPI00893737   
Protein Interaction databases
DIP (DOE-UCLA)P30046
IntAct (EBI)P30046
FunCoupENSG00000099977
BioGRIDDDT
STRING (EMBL)DDT
ZODIACDDT
Ontologies - Pathways
QuickGOP30046
Ontology : AmiGOdopachrome isomerase activity  cytoplasm  D-dopachrome decarboxylase activity  melanin biosynthetic process  extracellular exosome  
Ontology : EGO-EBIdopachrome isomerase activity  cytoplasm  D-dopachrome decarboxylase activity  melanin biosynthetic process  extracellular exosome  
NDEx NetworkDDT
Atlas of Cancer Signalling NetworkDDT
Wikipedia pathwaysDDT
Orthology - Evolution
OrthoDB1652
GeneTree (enSembl)ENSG00000099977
Phylogenetic Trees/Animal Genes : TreeFamDDT
HOVERGENP30046
HOGENOMP30046
Homologs : HomoloGeneDDT
Homology/Alignments : Family Browser (UCSC)DDT
Gene fusions - Rearrangements
Fusion : MitelmanDIRC2/DDT [3q21.1/22q11.23]  [t(3;22)(q21;q11)]  
Fusion: TCGA_MDACCDIRC2 3q21.1 DDT 22q11.23 PRAD
Tumor Fusion PortalDDT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDT
dbVarDDT
ClinVarDDT
1000_GenomesDDT 
Exome Variant ServerDDT
ExAC (Exome Aggregation Consortium)ENSG00000099977
GNOMAD BrowserENSG00000099977
Genetic variants : HAPMAP1652
Genomic Variants (DGV)DDT [DGVbeta]
DECIPHERDDT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDT 
Mutations
ICGC Data PortalDDT 
TCGA Data PortalDDT 
Broad Tumor PortalDDT
OASIS PortalDDT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDT
DgiDB (Drug Gene Interaction Database)DDT
DoCM (Curated mutations)DDT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDT (select a term)
intoGenDDT
Cancer3DDDT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602750   
Orphanet
DisGeNETDDT
MedgenDDT
Genetic Testing Registry DDT
NextProtP30046 [Medical]
TSGene1652
GENETestsDDT
Target ValidationDDT
Huge Navigator DDT [HugePedia]
snp3D : Map Gene to Disease1652
BioCentury BCIQDDT
ClinGenDDT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1652
Chemical/Pharm GKB GenePA27197
Clinical trialDDT
Miscellaneous
canSAR (ICR)DDT (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDT
EVEXDDT
GoPubMedDDT
iHOPDDT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:10:11 CET 2017

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