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DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10

Written1998-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)HRH-J8
HGNC (Hugo) DDX10
HGNC Alias symbHRH-J8
Dbp4
HGNC Previous nameDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
LocusID (NCBI) 1662
Atlas_Id 35
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 108665069 and ends at 108940926 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping DDX10.png]
Local_order telomeric to ATM.
 
  DDX10 (11q22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD2L (11q23.3) / DDX10 (11q22.3)DDX10 (11q22.3) / CUL5 (11q22.3)DDX10 (11q22.3) / DDX10 (11q22.3)
DDX10 (11q22.3) / NUP98 (11p15.4)DDX10 (11q22.3) / SKA3 (13q12.11)DDX10 (11q22.3) / YAP1 (11q22.1)
DECR2 (16p13.3) / DDX10 (11q22.3)NUP98 (11p15.4) / DDX10 (11q22.3)

DNA/RNA

Description at least 12 exons; spans more than a 200-kb region
Transcription alternative splicing; 3.2 and 5.0 kb mRNA

Protein

Description contains 2 nuclear localization signals (NLS), a DEAD box (DEAD for: ASP-GLU_ALA-ASP)
Expression wide
Localisation nucleolus (probable)
Function putative ATP-dependent DEAD box RNA helicase; possible role in ribosome assembly through rRNA processing
Homology SPB4 and DRS1 (yeast)

Implicated in

Note
  
Entity inv (11)(p15q22)/MDS or AML --> NUP98- DDX10
Disease therapy related MDS and AML; de novo AML
Hybrid/Mutated Gene 5' NUP98 - 3' DDX10
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the charged amino acids domain of DDX11
  

Bibliography

The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.
Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M
Blood. 1997 ; 89 (11) : 3936-3944.
PMID 9166830
 
A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G
Genomics. 1996 ; 33 (2) : 199-206.
PMID 8660968
 

Citation

This paper should be referenced as such :
Jean-Loup Huret
DDX10 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 10)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):3-4.
Free journal version : [ pdf ]   [ DOI ]

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  inv(11)(p15q22) NUP98/DDX10::t(11;11)(p15;q22) NUP98/DDX10
t(4;11)(q21;p15) NUP98/RAP1GDS1
t(11;11)(q22;q23) C2CD2L/DDX10

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;13)(q22;q12) DDX10/SKA3

External links

Nomenclature
HGNC (Hugo)DDX10   2735
Cards
AtlasDDX10ID35
Entrez_Gene (NCBI)DDX10    DEAD-box helicase 10
AliasesDbp4; HRH-J8
GeneCards (Weizmann)DDX10
Ensembl hg19 (Hinxton)ENSG00000178105 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178105 [Gene_View]  ENSG00000178105 [Sequence]  chr11:108665069-108940926 [Contig_View]  DDX10 [Vega]
ICGC DataPortalENSG00000178105
TCGA cBioPortalDDX10
AceView (NCBI)DDX10
Genatlas (Paris)DDX10
SOURCE (Princeton)DDX10
Genetics Home Reference (NIH)DDX10
Genomic and cartography
GoldenPath hg38 (UCSC)DDX10  -     chr11:108665069-108940926 +  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX10  -     11q22.3   [Description]    (hg19-Feb_2009)
GoldenPathDDX10 - 11q22.3 [CytoView hg19]  DDX10 - 11q22.3 [CytoView hg38]
ImmunoBaseENSG00000178105
genome Data Viewer NCBIDDX10 [Mapview hg19]  
OMIM601235   
Gene and transcription
Genbank (Entrez)AB001343 AB040537 AB209884 AK296752 AK315216
RefSeq transcript (Entrez)NM_004398
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX10
Alternative Splicing GalleryENSG00000178105
Gene ExpressionDDX10 [ NCBI-GEO ]   DDX10 [ EBI - ARRAY_EXPRESS ]   DDX10 [ SEEK ]   DDX10 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX10 [ Firebrowse - Broad ]
GenevisibleExpression of DDX10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1662
GTEX Portal (Tissue expression)DDX10
Human Protein AtlasENSG00000178105-DDX10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13206   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13206  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13206
Splice isoforms : SwissVarQ13206
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ13206
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DUF4217    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    DUF4217 (PF13959)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam13959    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  DUF4217 (SM01178)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX10
Blocks (Seattle)DDX10
PDB (RSDB)2PL3   
PDB Europe2PL3   
PDB (PDBSum)2PL3   
PDB (IMB)2PL3   
Structural Biology KnowledgeBase2PL3   
SCOP (Structural Classification of Proteins)2PL3   
CATH (Classification of proteins structures)2PL3   
SuperfamilyQ13206
Human Protein Atlas [tissue]ENSG00000178105-DDX10 [tissue]
Peptide AtlasQ13206
HPRD03138
IPIIPI00297900   IPI00908600   IPI00982941   
Protein Interaction databases
DIP (DOE-UCLA)Q13206
IntAct (EBI)Q13206
BioGRIDDDX10
STRING (EMBL)DDX10
ZODIACDDX10
Ontologies - Pathways
QuickGOQ13206
Ontology : AmiGORNA binding  ATP binding  nucleus  rRNA processing  anterior head development  
Ontology : EGO-EBIRNA binding  ATP binding  nucleus  rRNA processing  anterior head development  
NDEx NetworkDDX10
Atlas of Cancer Signalling NetworkDDX10
Wikipedia pathwaysDDX10
Orthology - Evolution
OrthoDB1662
GeneTree (enSembl)ENSG00000178105
Phylogenetic Trees/Animal Genes : TreeFamDDX10
HOGENOMQ13206
Homologs : HomoloGeneDDX10
Homology/Alignments : Family Browser (UCSC)DDX10
Gene fusions - Rearrangements
Fusion : MitelmanC2CD2L/DDX10 [11q23.3/11q22.3]  
Fusion : MitelmanDDX10/SKA3 [11q22.3/13q12.11]  
Fusion : MitelmanNUP98/DDX10 [11p15.4/11q22.3]  
Fusion PortalC2CD2L 11q23.3 DDX10 11q22.3 LAML
Fusion : TICdbNUP98 [11p15.4]  -  DDX10 [11q22.3]
Fusion : Fusion_HubARHGAP20--DDX10    ARHGAP32--DDX10    ASPH--DDX10    C2CD2L--DDX10    CADM1--DDX10    CHAMP1--DDX10    DDX10--ACAT1    DDX10--ARNTL    DDX10--CUL5    DDX10--DDX10    DDX10--DHX35    DDX10--EXPH5    DDX10--EXT2    DDX10--GALNT7    DDX10--GPRC5C   
DDX10--HOXA11    DDX10--HOXA13    DDX10--HOXA9    DDX10--HOXC11    DDX10--HOXD11    DDX10--HOXD13    DDX10--KDELC2    DDX10--LIFR    DDX10--NTM    DDX10--NUP98    DDX10--OPCML    DDX10--PHF21A    DDX10--PICALM    DDX10--PMX1    DDX10--PREP   
DDX10--RAP1GDS1    DDX10--RIC3    DDX10--SKA3    DDX10--TBRG1    DDX10--TMBIM4    DDX10--TOP1    DDX10--YAP1    DECR2--DDX10    HRASLS5--DDX10    NUP98--DDX10    PEX1--DDX10    PICALM--DDX10    POLD3--DDX10    POU2F3--DDX10    TAF1D--DDX10   
Fusion : QuiverDDX10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX10 [hg38]
dbVarDDX10
ClinVarDDX10
MonarchDDX10
1000_GenomesDDX10 
Exome Variant ServerDDX10
GNOMAD BrowserENSG00000178105
Varsome BrowserDDX10
Genomic Variants (DGV)DDX10 [DGVbeta]
DECIPHERDDX10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX10 
Mutations
ICGC Data PortalDDX10 
TCGA Data PortalDDX10 
Broad Tumor PortalDDX10
OASIS PortalDDX10 [ Somatic mutations - Copy number]
Cancer Gene: CensusDDX10 
Somatic Mutations in Cancer : COSMICDDX10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDX10
Mutations and Diseases : HGMDDDX10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX10
DgiDB (Drug Gene Interaction Database)DDX10
DoCM (Curated mutations)DDX10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX10 (select a term)
intoGenDDX10
OncoKBDDX10
NCG6 (London) select DDX10
Cancer3DDDX10(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601235   
Orphanet
DisGeNETDDX10
MedgenDDX10
Genetic Testing Registry DDX10
NextProtQ13206 [Medical]
GENETestsDDX10
Target ValidationDDX10
Huge Navigator DDX10 [HugePedia]
ClinGenDDX10
Clinical trials, drugs, therapy
MyCancerGenomeDDX10
Protein Interactions : CTD
Pharm GKB GenePA27200
PharosQ13206
Clinical trialDDX10
Miscellaneous
canSAR (ICR)DDX10 (select the gene name)
HarmonizomeDDX10
DataMed IndexDDX10
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDDX10
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:49:54 CET 2021
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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.