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DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10

Written1998-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Alias_namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
Alias_symbol (synonym)HRH-J8
Other alias
HGNC (Hugo) DDX10
LocusID (NCBI) 1662
Atlas_Id 35
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 108665025 and ends at 108940930 bp from pter ( according to hg19-Feb_2009)  [Mapping DDX10.png]
Local_order telomeric to ATM.
  DDX10 (11q22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD2L (11q23.3) / DDX10 (11q22.3)DDX10 (11q22.3) / CUL5 (11q22.3)DDX10 (11q22.3) / DDX10 (11q22.3)
DDX10 (11q22.3) / NUP98 (11p15.4)DDX10 (11q22.3) / SKA3 (13q12.11)DDX10 (11q22.3) / YAP1 (11q22.1)
DECR2 (16p13.3) / DDX10 (11q22.3)NUP98 (11p15.4) / DDX10 (11q22.3)


Description at least 12 exons; spans more than a 200-kb region
Transcription alternative splicing; 3.2 and 5.0 kb mRNA


Description contains 2 nuclear localization signals (NLS), a DEAD box (DEAD for: ASP-GLU_ALA-ASP)
Expression wide
Localisation nucleolus (probable)
Function putative ATP-dependent DEAD box RNA helicase; possible role in ribosome assembly through rRNA processing
Homology SPB4 and DRS1 (yeast)

Implicated in

Entity inv (11)(p15q22)/MDS or AML --> NUP98- DDX10
Disease therapy related MDS and AML; de novo AML
Hybrid/Mutated Gene 5' NUP98 - 3' DDX10
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the charged amino acids domain of DDX11


The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.
Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M
Blood. 1997 ; 89 (11) : 3936-3944.
PMID 9166830
A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G
Genomics. 1996 ; 33 (2) : 199-206.
PMID 8660968


This paper should be referenced as such :
Jean-Loup Huret
DDX10 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 10)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):3-4.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  inv(11)(p15q22) NUP98/DDX10::t(11;11)(p15;q22) NUP98/DDX10
t(11;11)(q22;q23) C2CD2L/DDX10

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;13)(q22;q12) DDX10/SKA3

External links

HGNC (Hugo)DDX10   2735
Entrez_Gene (NCBI)DDX10  1662  DEAD-box helicase 10
AliasesDbp4; HRH-J8
GeneCards (Weizmann)DDX10
Ensembl hg19 (Hinxton)ENSG00000178105 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178105 [Gene_View]  ENSG00000178105 [Sequence]  chr11:108665025-108940930 [Contig_View]  DDX10 [Vega]
ICGC DataPortalENSG00000178105
TCGA cBioPortalDDX10
AceView (NCBI)DDX10
Genatlas (Paris)DDX10
SOURCE (Princeton)DDX10
Genetics Home Reference (NIH)DDX10
Genomic and cartography
GoldenPath hg38 (UCSC)DDX10  -     chr11:108665025-108940930 +  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX10  -     11q22.3   [Description]    (hg19-Feb_2009)
DDX10 - 11q22.3 [CytoView hg19]  DDX10 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBIDDX10 [Mapview hg19]  DDX10 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB001343 AB040537 AB209884 AK296752 AK315216
RefSeq transcript (Entrez)NM_004398
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX10
Cluster EST : UnigeneHs.591931 [ NCBI ]
CGAP (NCI)Hs.591931
Alternative Splicing GalleryENSG00000178105
Gene ExpressionDDX10 [ NCBI-GEO ]   DDX10 [ EBI - ARRAY_EXPRESS ]   DDX10 [ SEEK ]   DDX10 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1662
GTEX Portal (Tissue expression)DDX10
Human Protein AtlasENSG00000178105-DDX10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13206   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13206  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13206
Splice isoforms : SwissVarQ13206
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ] [ IntEnz-EBI ] [ BRENDA ] [ KEGG ]   
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DUF4217    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    DUF4217 (PF13959)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam13959    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  DUF4217 (SM01178)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX10
DMDM Disease mutations1662
Blocks (Seattle)DDX10
PDB Europe2PL3   
PDB (PDBSum)2PL3   
PDB (IMB)2PL3   
Structural Biology KnowledgeBase2PL3   
SCOP (Structural Classification of Proteins)2PL3   
CATH (Classification of proteins structures)2PL3   
Human Protein Atlas [tissue]ENSG00000178105-DDX10 [tissue]
Peptide AtlasQ13206
IPIIPI00297900   IPI00908600   IPI00982941   
Protein Interaction databases
IntAct (EBI)Q13206
Ontologies - Pathways
Ontology : AmiGORNA binding  RNA helicase activity  ATP binding  anterior head development  
Ontology : EGO-EBIRNA binding  RNA helicase activity  ATP binding  anterior head development  
NDEx NetworkDDX10
Atlas of Cancer Signalling NetworkDDX10
Wikipedia pathwaysDDX10
Orthology - Evolution
GeneTree (enSembl)ENSG00000178105
Phylogenetic Trees/Animal Genes : TreeFamDDX10
Homologs : HomoloGeneDDX10
Homology/Alignments : Family Browser (UCSC)DDX10
Gene fusions - Rearrangements
Fusion : MitelmanC2CD2L/DDX10 [11q23.3/11q22.3]  [t(11;11)(q22;q23)]  
Fusion : MitelmanDDX10/SKA3 [11q22.3/13q12.11]  [t(11;13)(q22;q12)]  
Fusion : MitelmanNUP98/DDX10 [11p15.4/11q22.3]  [inv(11)(p15q22)]  
Fusion PortalC2CD2L 11q23.3 DDX10 11q22.3 LAML
Fusion : TICdbNUP98 [11p15.4]  -  DDX10 [11q22.3]
Fusion : FusionGDB25254    3236    4922    9547    9548    9549    9550    9551    9552    9553    9682   
Fusion : QuiverDDX10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX10
Exome Variant ServerDDX10
ExAC (Exome Aggregation Consortium)ENSG00000178105
GNOMAD BrowserENSG00000178105
Varsome BrowserDDX10
Genetic variants : HAPMAP1662
Genomic Variants (DGV)DDX10 [DGVbeta]
DECIPHERDDX10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX10 
ICGC Data PortalDDX10 
TCGA Data PortalDDX10 
Broad Tumor PortalDDX10
OASIS PortalDDX10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDX10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX10
DgiDB (Drug Gene Interaction Database)DDX10
DoCM (Curated mutations)DDX10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX10 (select a term)
NCG5 (London)DDX10
Cancer3DDDX10(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry DDX10
NextProtQ13206 [Medical]
Target ValidationDDX10
Huge Navigator DDX10 [HugePedia]
snp3D : Map Gene to Disease1662
BioCentury BCIQDDX10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1662
Chemical/Pharm GKB GenePA27200
Clinical trialDDX10
canSAR (ICR)DDX10 (select the gene name)
DataMed IndexDDX10
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 21 16:22:25 CET 2019

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