| Written | 1998-01 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| Alias (NCBI) | HRH-J8 |
| HGNC (Hugo) | DDX10 |
| HGNC Alias symb | HRH-J8 | Dbp4 |
| HGNC Previous name | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 |
| LocusID (NCBI) | 1662 |
| Atlas_Id | 35 |
| Location | 11q22.3 [Link to chromosome band 11q22] |
| Location_base_pair | Starts at 108665069 and ends at 108940926 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping DDX10.png] |
| Local_order | telomeric to ATM. |
 | |
| DDX10 (11q22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. | |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| C2CD2L (11q23.3)::DDX10 (11q22.3) | DDX10 (11q22.3)::CUL5 (11q22.3) | DDX10 (11q22.3)::DDX10 (11q22.3) | |
| DDX10 (11q22.3)::NUP98 (11p15.4) | DDX10 (11q22.3)::SKA3 (13q12.11) | DDX10 (11q22.3)::YAP1 (11q22.1) | |
| DECR2 (16p13.3)::DDX10 (11q22.3) | NUP98 (11p15.4)::DDX10 (11q22.3) |
| DNA/RNA |
| Description | at least 12 exons; spans more than a 200-kb region |
| Transcription | alternative splicing; 3.2 and 5.0 kb mRNA |
| Protein |
| Description | contains 2 nuclear localization signals (NLS), a DEAD box (DEAD for: ASP-GLU_ALA-ASP) |
| Expression | wide |
| Localisation | nucleolus (probable) |
| Function | putative ATP-dependent DEAD box RNA helicase; possible role in ribosome assembly through rRNA processing |
| Homology | SPB4 and DRS1 (yeast) |
| Implicated in |
| Note | |
| Entity | inv |
| Disease | therapy related MDS and AML; de novo AML |
| Hybrid/Mutated Gene | 5' NUP98 - 3' DDX10 |
| Abnormal Protein | fuses the GLFG repeat domains of NUP98 to the charged amino acids domain of DDX11 |
| Bibliography |
| The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. |
| Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M |
| Blood. 1997 ; 89 (11) : 3936-3944. |
| PMID 9166830 |
| A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. |
| Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G |
| Genomics. 1996 ; 33 (2) : 199-206. |
| PMID 8660968 |
| Citation |
| This paper should be referenced as such : |
| Jean-Loup Huret |
| DDX10 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 10) |
| Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):3-4. |
| Free journal version : [ pdf ] [ DOI ] |
| Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ] |
|
inv(11)(p15q22) NUP98::DDX10::t(11;11)(p15;q22) NUP98/DDX10
t(4;11)(q21;p15) NUP98::RAP1GDS1 Therapy-Related Hematopoietic Neoplasia t(11;11)(q22;q23) C2CD2L::DDX10 |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Jan 17 15:29:35 CET 2022 |
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