Written | 1998-01 | Jean-Loup Huret |
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
Identity |
Alias (NCBI) | HRH-J8 |
HGNC (Hugo) | DDX10 |
HGNC Alias symb | HRH-J8 | Dbp4 |
HGNC Previous name | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 |
LocusID (NCBI) | 1662 |
Atlas_Id | 35 |
Location | 11q22.3 [Link to chromosome band 11q22] |
Location_base_pair | Starts at 108665069 and ends at 108940926 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping DDX10.png] |
Local_order | telomeric to ATM. |
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DDX10 (11q22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. | |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
C2CD2L (11q23.3) / DDX10 (11q22.3) | DDX10 (11q22.3) / CUL5 (11q22.3) | DDX10 (11q22.3) / DDX10 (11q22.3) | |
DDX10 (11q22.3) / NUP98 (11p15.4) | DDX10 (11q22.3) / SKA3 (13q12.11) | DDX10 (11q22.3) / YAP1 (11q22.1) | |
DECR2 (16p13.3) / DDX10 (11q22.3) | NUP98 (11p15.4) / DDX10 (11q22.3) |
DNA/RNA |
Description | at least 12 exons; spans more than a 200-kb region |
Transcription | alternative splicing; 3.2 and 5.0 kb mRNA |
Protein |
Description | contains 2 nuclear localization signals (NLS), a DEAD box (DEAD for: ASP-GLU_ALA-ASP) |
Expression | wide |
Localisation | nucleolus (probable) |
Function | putative ATP-dependent DEAD box RNA helicase; possible role in ribosome assembly through rRNA processing |
Homology | SPB4 and DRS1 (yeast) |
Implicated in |
Note | |
Entity | inv (11)(p15q22)/MDS or AML --> NUP98- DDX10 |
Disease | therapy related MDS and AML; de novo AML |
Hybrid/Mutated Gene | 5' NUP98 - 3' DDX10 |
Abnormal Protein | fuses the GLFG repeat domains of NUP98 to the charged amino acids domain of DDX11 |
Bibliography |
The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. |
Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M |
Blood. 1997 ; 89 (11) : 3936-3944. |
PMID 9166830 |
A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. |
Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G |
Genomics. 1996 ; 33 (2) : 199-206. |
PMID 8660968 |
Citation |
This paper should be referenced as such : |
Jean-Loup Huret |
DDX10 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 10) |
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):3-4. |
Free journal version : [ pdf ] [ DOI ] |
Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ] |
inv(11)(p15q22) NUP98/DDX10::t(11;11)(p15;q22) NUP98/DDX10
t(4;11)(q21;p15) NUP98/RAP1GDS1 t(11;11)(q22;q23) C2CD2L/DDX10 |
Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ] |
t(11;13)(q22;q12) DDX10/SKA3
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External links |
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Jan 1 18:49:54 CET 2021 |
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