Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DDX11 (DEAD/H-box helicase 11)

Identity

Alias_namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (S.cerevisiae CHL1-like helicase)
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Alias_symbol (synonym)CHLR1
KRG2
CHL1
ChlR1
WABS
Other alias
HGNC (Hugo) DDX11
LocusID (NCBI) 1663
Atlas_Id 40284
Location 12p11.21  [Link to chromosome band 12p11]
Location_base_pair Starts at 31073845 and ends at 31104791 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DDX11   2736
Cards
Entrez_Gene (NCBI)DDX11  1663  DEAD/H-box helicase 11
AliasesCHL1; CHLR1; KRG2; WABS
GeneCards (Weizmann)DDX11
Ensembl hg19 (Hinxton)ENSG00000013573 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000013573 [Gene_View]  chr12:31073845-31104791 [Contig_View]  DDX11 [Vega]
ICGC DataPortalENSG00000013573
TCGA cBioPortalDDX11
AceView (NCBI)DDX11
Genatlas (Paris)DDX11
WikiGenes1663
SOURCE (Princeton)DDX11
Genetics Home Reference (NIH)DDX11
Genomic and cartography
GoldenPath hg38 (UCSC)DDX11  -     chr12:31073845-31104791 +  12p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX11  -     12p11.21   [Description]    (hg19-Feb_2009)
EnsemblDDX11 - 12p11.21 [CytoView hg19]  DDX11 - 12p11.21 [CytoView hg38]
Mapping of homologs : NCBIDDX11 [Mapview hg19]  DDX11 [Mapview hg38]
OMIM601150   613398   
Gene and transcription
Genbank (Entrez)AK021703 AK297607 AK303139 BC001591 BC011264
RefSeq transcript (Entrez)NM_001257144 NM_001257145 NM_004399 NM_030653 NM_030655 NM_152438
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX11
Cluster EST : UnigeneHs.443960 [ NCBI ]
CGAP (NCI)Hs.443960
Alternative Splicing GalleryENSG00000013573
Gene ExpressionDDX11 [ NCBI-GEO ]   DDX11 [ EBI - ARRAY_EXPRESS ]   DDX11 [ SEEK ]   DDX11 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1663
GTEX Portal (Tissue expression)DDX11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96FC9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96FC9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96FC9
Splice isoforms : SwissVarQ96FC9
PhosPhoSitePlusQ96FC9
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_2 (PS51193)   
Domains : Interpro (EBI)ATP-dep_Helicase_C    DEAD_2    DNA_helicase_DNA-repair_Rad3    Helic_SF1/SF2_ATP-bd_DinG/Rad3    Helicase-like_DEXD_c2    P-loop_NTPase   
Domain families : Pfam (Sanger)DEAD_2 (PF06733)    Helicase_C_2 (PF13307)   
Domain families : Pfam (NCBI)pfam06733    pfam13307   
Domain families : Smart (EMBL)DEXDc2 (SM00488)  HELICc2 (SM00491)  
Conserved Domain (NCBI)DDX11
DMDM Disease mutations1663
Blocks (Seattle)DDX11
SuperfamilyQ96FC9
Human Protein AtlasENSG00000013573
Peptide AtlasQ96FC9
HPRD03095
IPIIPI00657836   IPI00658184   IPI00332293   IPI00012188   IPI00910460   IPI00942296   IPI01015699   IPI00909981   IPI00943235   IPI01012139   IPI01012155   IPI01011771   IPI01011296   IPI01010700   IPI01010239   IPI01009890   IPI01009420   IPI01014025   
Protein Interaction databases
DIP (DOE-UCLA)Q96FC9
IntAct (EBI)Q96FC9
FunCoupENSG00000013573
BioGRIDDDX11
STRING (EMBL)DDX11
ZODIACDDX11
Ontologies - Pathways
QuickGOQ96FC9
Ontology : AmiGOnuclear chromatin  spindle pole  fibrillar center  DNA binding  chromatin binding  chromatin binding  DNA replication origin binding  double-stranded DNA binding  single-stranded DNA binding  single-stranded RNA binding  ATP-dependent DNA helicase activity  helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  centrosome  DNA repair  transcription, DNA-templated  cellular response to DNA damage stimulus  sister chromatid cohesion  multicellular organism development  ATP-dependent helicase activity  DNA-dependent ATPase activity  DNA-dependent ATPase activity  RNA-dependent ATPase activity  viral process  midbody  mitotic cohesin complex  replication fork processing  Ctf18 RFC-like complex  positive regulation of endodeoxyribonuclease activity  negative regulation of protein binding  DNA duplex unwinding  positive regulation of chromatin binding  IRE1-mediated unfolded protein response  G-quadruplex DNA unwinding  triplex DNA binding  positive regulation of sister chromatid cohesion  metal ion binding  4 iron, 4 sulfur cluster binding  G-quadruplex DNA binding  extracellular exosome  cellular response to hydroxyurea  cellular response to cisplatin  positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter  cellular response to bleomycin  nucleolar chromatin organization  positive regulation of double-strand break repair  
Ontology : EGO-EBInuclear chromatin  spindle pole  fibrillar center  DNA binding  chromatin binding  chromatin binding  DNA replication origin binding  double-stranded DNA binding  single-stranded DNA binding  single-stranded RNA binding  ATP-dependent DNA helicase activity  helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  centrosome  DNA repair  transcription, DNA-templated  cellular response to DNA damage stimulus  sister chromatid cohesion  multicellular organism development  ATP-dependent helicase activity  DNA-dependent ATPase activity  DNA-dependent ATPase activity  RNA-dependent ATPase activity  viral process  midbody  mitotic cohesin complex  replication fork processing  Ctf18 RFC-like complex  positive regulation of endodeoxyribonuclease activity  negative regulation of protein binding  DNA duplex unwinding  positive regulation of chromatin binding  IRE1-mediated unfolded protein response  G-quadruplex DNA unwinding  triplex DNA binding  positive regulation of sister chromatid cohesion  metal ion binding  4 iron, 4 sulfur cluster binding  G-quadruplex DNA binding  extracellular exosome  cellular response to hydroxyurea  cellular response to cisplatin  positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter  cellular response to bleomycin  nucleolar chromatin organization  positive regulation of double-strand break repair  
NDEx NetworkDDX11
Atlas of Cancer Signalling NetworkDDX11
Wikipedia pathwaysDDX11
Orthology - Evolution
OrthoDB1663
GeneTree (enSembl)ENSG00000013573
Phylogenetic Trees/Animal Genes : TreeFamDDX11
HOVERGENQ96FC9
HOGENOMQ96FC9
Homologs : HomoloGeneDDX11
Homology/Alignments : Family Browser (UCSC)DDX11
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX11
dbVarDDX11
ClinVarDDX11
1000_GenomesDDX11 
Exome Variant ServerDDX11
ExAC (Exome Aggregation Consortium)DDX11 (select the gene name)
Genetic variants : HAPMAP1663
Genomic Variants (DGV)DDX11 [DGVbeta]
DECIPHERDDX11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX11 
Mutations
ICGC Data PortalDDX11 
TCGA Data PortalDDX11 
Broad Tumor PortalDDX11
OASIS PortalDDX11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDX11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX11
DgiDB (Drug Gene Interaction Database)DDX11
DoCM (Curated mutations)DDX11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX11 (select a term)
intoGenDDX11
Cancer3DDDX11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601150    613398   
Orphanet20473   
MedgenDDX11
Genetic Testing Registry DDX11
NextProtQ96FC9 [Medical]
TSGene1663
GENETestsDDX11
Target ValidationDDX11
Huge Navigator DDX11 [HugePedia]
snp3D : Map Gene to Disease1663
BioCentury BCIQDDX11
ClinGenDDX11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1663
Chemical/Pharm GKB GenePA27201
Clinical trialDDX11
Miscellaneous
canSAR (ICR)DDX11 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDX11
EVEXDDX11
GoPubMedDDX11
iHOPDDX11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:51:25 CEST 2017

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