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DDX17 (DEAD-box helicase 17)

Identity

Alias_namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
DEAD (Asp-Glu-Ala-Asp) box helicase 17
Alias_symbol (synonym)P72
Other aliasRH70
HGNC (Hugo) DDX17
LocusID (NCBI) 10521
Atlas_Id 47340
Location 22q13.1  [Link to chromosome band 22q13]
Location_base_pair Starts at 38483438 and ends at 38506340 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DDX17 (22q13.1) / ATXN10 (22q13.31)DDX17 (22q13.1) / DDX17 (22q13.1)DDX17 (22q13.1) / DSP (6p24.3)
DDX17 (22q13.1) / KDELR3 (22q13.1)EIF4G2 (11p15.3) / DDX17 (22q13.1)GARS (7p14.3) / DDX17 (22q13.1)
HSPB1 (7q11.23) / DDX17 (22q13.1)PTMS (12p13.31) / DDX17 (22q13.1)SAFB2 (19p13.3) / DDX17 (22q13.1)
SRRM1 (1p36.11) / DDX17 (22q13.1)TGM2 (20q11.23) / DDX17 (22q13.1)WDR70 (5p13.2) / DDX17 (22q13.1)
ZFR2 (19p13.3) / DDX17 (22q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DDX17   2740
Cards
Entrez_Gene (NCBI)DDX17  10521  DEAD-box helicase 17
AliasesP72; RH70
GeneCards (Weizmann)DDX17
Ensembl hg19 (Hinxton)ENSG00000100201 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100201 [Gene_View]  chr22:38483438-38506340 [Contig_View]  DDX17 [Vega]
ICGC DataPortalENSG00000100201
TCGA cBioPortalDDX17
AceView (NCBI)DDX17
Genatlas (Paris)DDX17
WikiGenes10521
SOURCE (Princeton)DDX17
Genetics Home Reference (NIH)DDX17
Genomic and cartography
GoldenPath hg38 (UCSC)DDX17  -     chr22:38483438-38506340 -  22q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX17  -     22q13.1   [Description]    (hg19-Feb_2009)
EnsemblDDX17 - 22q13.1 [CytoView hg19]  DDX17 - 22q13.1 [CytoView hg38]
Mapping of homologs : NCBIDDX17 [Mapview hg19]  DDX17 [Mapview hg38]
OMIM608469   
Gene and transcription
Genbank (Entrez)AA765457 AB209595 AF131750 AK024985 AK074224
RefSeq transcript (Entrez)NM_001098504 NM_001098505 NM_006386 NM_030881
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX17
Cluster EST : UnigeneHs.706116 [ NCBI ]
CGAP (NCI)Hs.706116
Alternative Splicing GalleryENSG00000100201
Gene ExpressionDDX17 [ NCBI-GEO ]   DDX17 [ EBI - ARRAY_EXPRESS ]   DDX17 [ SEEK ]   DDX17 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX17 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10521
GTEX Portal (Tissue expression)DDX17
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92841   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92841  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92841
Splice isoforms : SwissVarQ92841
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ92841
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX17
DMDM Disease mutations10521
Blocks (Seattle)DDX17
SuperfamilyQ92841
Human Protein AtlasENSG00000100201
Peptide AtlasQ92841
HPRD10532
IPIIPI00651677   IPI00889541   IPI00879638   IPI01022339   IPI01022656   IPI00847768   IPI00952778   IPI00651653   
Protein Interaction databases
DIP (DOE-UCLA)Q92841
IntAct (EBI)Q92841
FunCoupENSG00000100201
BioGRIDDDX17
STRING (EMBL)DDX17
ZODIACDDX17
Ontologies - Pathways
QuickGOQ92841
Ontology : AmiGOalternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  epithelial to mesenchymal transition  transcription coactivator activity  RNA binding  RNA helicase activity  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleolus  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  rRNA processing  RNA processing  RNA-dependent ATPase activity  RNA secondary structure unwinding  miRNA metabolic process  membrane  nuclear speck  estrogen receptor binding  intracellular estrogen receptor signaling pathway  androgen receptor signaling pathway  gene silencing by RNA  positive regulation of intracellular estrogen receptor signaling pathway  myoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  regulation of skeletal muscle cell differentiation  
Ontology : EGO-EBIalternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  epithelial to mesenchymal transition  transcription coactivator activity  RNA binding  RNA helicase activity  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleolus  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  rRNA processing  RNA processing  RNA-dependent ATPase activity  RNA secondary structure unwinding  miRNA metabolic process  membrane  nuclear speck  estrogen receptor binding  intracellular estrogen receptor signaling pathway  androgen receptor signaling pathway  gene silencing by RNA  positive regulation of intracellular estrogen receptor signaling pathway  myoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  regulation of skeletal muscle cell differentiation  
NDEx NetworkDDX17
Atlas of Cancer Signalling NetworkDDX17
Wikipedia pathwaysDDX17
Orthology - Evolution
OrthoDB10521
GeneTree (enSembl)ENSG00000100201
Phylogenetic Trees/Animal Genes : TreeFamDDX17
HOVERGENQ92841
HOGENOMQ92841
Homologs : HomoloGeneDDX17
Homology/Alignments : Family Browser (UCSC)DDX17
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX17
dbVarDDX17
ClinVarDDX17
1000_GenomesDDX17 
Exome Variant ServerDDX17
ExAC (Exome Aggregation Consortium)DDX17 (select the gene name)
Genetic variants : HAPMAP10521
Genomic Variants (DGV)DDX17 [DGVbeta]
DECIPHERDDX17 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX17 
Mutations
ICGC Data PortalDDX17 
TCGA Data PortalDDX17 
Broad Tumor PortalDDX17
OASIS PortalDDX17 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX17  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDX17
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX17
DgiDB (Drug Gene Interaction Database)DDX17
DoCM (Curated mutations)DDX17 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX17 (select a term)
intoGenDDX17
Cancer3DDDX17(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608469   
Orphanet
MedgenDDX17
Genetic Testing Registry DDX17
NextProtQ92841 [Medical]
TSGene10521
GENETestsDDX17
Target ValidationDDX17
Huge Navigator DDX17 [HugePedia]
snp3D : Map Gene to Disease10521
BioCentury BCIQDDX17
ClinGenDDX17
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10521
Chemical/Pharm GKB GenePA27206
Clinical trialDDX17
Miscellaneous
canSAR (ICR)DDX17 (select the gene name)
Probes
Litterature
PubMed142 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDX17
EVEXDDX17
GoPubMedDDX17
iHOPDDX17
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:30:49 CEST 2017

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