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DDX18 (DEAD-box helicase 18)

Identity

Alias_namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
Alias_symbol (synonym)MrDb
Other alias
HGNC (Hugo) DDX18
LocusID (NCBI) 8886
Atlas_Id 40286
Location 2q14.1  [Link to chromosome band 2q14]
Location_base_pair Starts at 117814679 and ends at 117832377 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DDX18 (2q14.1) / TSPAN9 (12p13.33)IBTK (6q14.1) / DDX18 (2q14.1)MFHAS1 (8p23.1) / DDX18 (2q14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DDX18   2741
Cards
Entrez_Gene (NCBI)DDX18  8886  DEAD-box helicase 18
AliasesMrDb
GeneCards (Weizmann)DDX18
Ensembl hg19 (Hinxton)ENSG00000088205 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088205 [Gene_View]  chr2:117814679-117832377 [Contig_View]  DDX18 [Vega]
ICGC DataPortalENSG00000088205
TCGA cBioPortalDDX18
AceView (NCBI)DDX18
Genatlas (Paris)DDX18
WikiGenes8886
SOURCE (Princeton)DDX18
Genetics Home Reference (NIH)DDX18
Genomic and cartography
GoldenPath hg38 (UCSC)DDX18  -     chr2:117814679-117832377 +  2q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX18  -     2q14.1   [Description]    (hg19-Feb_2009)
EnsemblDDX18 - 2q14.1 [CytoView hg19]  DDX18 - 2q14.1 [CytoView hg38]
Mapping of homologs : NCBIDDX18 [Mapview hg19]  DDX18 [Mapview hg38]
OMIM606355   
Gene and transcription
Genbank (Entrez)AB209392 AK001467 AK091227 BC001238 BC003360
RefSeq transcript (Entrez)NM_006773
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX18
Cluster EST : UnigeneHs.744922 [ NCBI ]
CGAP (NCI)Hs.744922
Alternative Splicing GalleryENSG00000088205
Gene ExpressionDDX18 [ NCBI-GEO ]   DDX18 [ EBI - ARRAY_EXPRESS ]   DDX18 [ SEEK ]   DDX18 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8886
GTEX Portal (Tissue expression)DDX18
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVP1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVP1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVP1
Splice isoforms : SwissVarQ9NVP1
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ9NVP1
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DUF4217    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    DUF4217 (PF13959)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam13959    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  DUF4217 (SM01178)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX18
DMDM Disease mutations8886
Blocks (Seattle)DDX18
PDB (SRS)3LY5   
PDB (PDBSum)3LY5   
PDB (IMB)3LY5   
PDB (RSDB)3LY5   
Structural Biology KnowledgeBase3LY5   
SCOP (Structural Classification of Proteins)3LY5   
CATH (Classification of proteins structures)3LY5   
SuperfamilyQ9NVP1
Human Protein AtlasENSG00000088205
Peptide AtlasQ9NVP1
HPRD05894
IPIIPI00301323   IPI01012260   IPI00555700   IPI00657846   
Protein Interaction databases
DIP (DOE-UCLA)Q9NVP1
IntAct (EBI)Q9NVP1
FunCoupENSG00000088205
BioGRIDDDX18
STRING (EMBL)DDX18
ZODIACDDX18
Ontologies - Pathways
QuickGOQ9NVP1
Ontology : AmiGORNA binding  ATP-dependent RNA helicase activity  protein binding  ATP binding  chromosome  nucleolus  RNA secondary structure unwinding  membrane  cellular response to estradiol stimulus  
Ontology : EGO-EBIRNA binding  ATP-dependent RNA helicase activity  protein binding  ATP binding  chromosome  nucleolus  RNA secondary structure unwinding  membrane  cellular response to estradiol stimulus  
NDEx NetworkDDX18
Atlas of Cancer Signalling NetworkDDX18
Wikipedia pathwaysDDX18
Orthology - Evolution
OrthoDB8886
GeneTree (enSembl)ENSG00000088205
Phylogenetic Trees/Animal Genes : TreeFamDDX18
HOVERGENQ9NVP1
HOGENOMQ9NVP1
Homologs : HomoloGeneDDX18
Homology/Alignments : Family Browser (UCSC)DDX18
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX18
dbVarDDX18
ClinVarDDX18
1000_GenomesDDX18 
Exome Variant ServerDDX18
ExAC (Exome Aggregation Consortium)DDX18 (select the gene name)
Genetic variants : HAPMAP8886
Genomic Variants (DGV)DDX18 [DGVbeta]
DECIPHERDDX18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX18 
Mutations
ICGC Data PortalDDX18 
TCGA Data PortalDDX18 
Broad Tumor PortalDDX18
OASIS PortalDDX18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDX18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX18
DgiDB (Drug Gene Interaction Database)DDX18
DoCM (Curated mutations)DDX18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX18 (select a term)
intoGenDDX18
Cancer3DDDX18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606355   
Orphanet
MedgenDDX18
Genetic Testing Registry DDX18
NextProtQ9NVP1 [Medical]
TSGene8886
GENETestsDDX18
Target ValidationDDX18
Huge Navigator DDX18 [HugePedia]
snp3D : Map Gene to Disease8886
BioCentury BCIQDDX18
ClinGenDDX18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8886
Chemical/Pharm GKB GenePA27207
Clinical trialDDX18
Miscellaneous
canSAR (ICR)DDX18 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDX18
EVEXDDX18
GoPubMedDDX18
iHOPDDX18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:04:58 CEST 2017

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