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DDX19B (DEAD-box helicase 19B)

Identity

Alias_namesDDX19
DEAD (Asp-Glu-Ala-As) box polypeptide 19
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (Dbp5, yeast, homolog)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
Alias_symbol (synonym)DBP5
Other aliasRNAh
HGNC (Hugo) DDX19B
LocusID (NCBI) 11269
Atlas_Id 46753
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 70299159 and ends at 70333832 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CARD8 (19q13.33) / DDX19B (16q22.1)DDX19B (16q22.1) / APOB (2p24.1)DDX19B (16q22.1) / HNRNPM (19p13.2)
DDX19B (16q22.1) / KCTD19 (16q22.1)HTRA2 (2p13.1) / DDX19B (16q22.1)SF3B3 (16q22.1) / DDX19B (16q22.1)
TGIF1 (18p11.31) / DDX19B (16q22.1)DDX19B 16q22.1 / KCTD19 16q22.1SF3B3 16q22.1 / DDX19B 16q22.1
TGIF1 18p11.31 / DDX19B 16q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DDX19B   2742
Cards
Entrez_Gene (NCBI)DDX19B  11269  DEAD-box helicase 19B
AliasesDBP5; DDX19; RNAh
GeneCards (Weizmann)DDX19B
Ensembl hg19 (Hinxton)ENSG00000157349 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157349 [Gene_View]  chr16:70299159-70333832 [Contig_View]  DDX19B [Vega]
ICGC DataPortalENSG00000157349
TCGA cBioPortalDDX19B
AceView (NCBI)DDX19B
Genatlas (Paris)DDX19B
WikiGenes11269
SOURCE (Princeton)DDX19B
Genetics Home Reference (NIH)DDX19B
Genomic and cartography
GoldenPath hg38 (UCSC)DDX19B  -     chr16:70299159-70333832 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX19B  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblDDX19B - 16q22.1 [CytoView hg19]  DDX19B - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBIDDX19B [Mapview hg19]  DDX19B [Mapview hg38]
OMIM605812   
Gene and transcription
Genbank (Entrez)AF353720 AJ237946 AK027378 AK223115 AK296868
RefSeq transcript (Entrez)NM_001014449 NM_001014451 NM_001257172 NM_001257173 NM_001257174 NM_001257175 NM_007242
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX19B
Cluster EST : UnigeneHs.221761 [ NCBI ]
CGAP (NCI)Hs.221761
Alternative Splicing GalleryENSG00000157349
Gene ExpressionDDX19B [ NCBI-GEO ]   DDX19B [ EBI - ARRAY_EXPRESS ]   DDX19B [ SEEK ]   DDX19B [ MEM ]
Gene Expression Viewer (FireBrowse)DDX19B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11269
GTEX Portal (Tissue expression)DDX19B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UMR2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UMR2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UMR2
Splice isoforms : SwissVarQ9UMR2
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ9UMR2
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX19B
DMDM Disease mutations11269
Blocks (Seattle)DDX19B
PDB (SRS)3EWS    3FHC    3FHT    3FMO    3FMP    3G0H   
PDB (PDBSum)3EWS    3FHC    3FHT    3FMO    3FMP    3G0H   
PDB (IMB)3EWS    3FHC    3FHT    3FMO    3FMP    3G0H   
PDB (RSDB)3EWS    3FHC    3FHT    3FMO    3FMP    3G0H   
Structural Biology KnowledgeBase3EWS    3FHC    3FHT    3FMO    3FMP    3G0H   
SCOP (Structural Classification of Proteins)3EWS    3FHC    3FHT    3FMO    3FMP    3G0H   
CATH (Classification of proteins structures)3EWS    3FHC    3FHT    3FMO    3FMP    3G0H   
SuperfamilyQ9UMR2
Human Protein AtlasENSG00000157349
Peptide AtlasQ9UMR2
HPRD05781
IPIIPI00008943   IPI00939593   IPI00556368   IPI00027599   
Protein Interaction databases
DIP (DOE-UCLA)Q9UMR2
IntAct (EBI)Q9UMR2
FunCoupENSG00000157349
BioGRIDDDX19B
STRING (EMBL)DDX19B
ZODIACDDX19B
Ontologies - Pathways
QuickGOQ9UMR2
Ontology : AmiGORNA binding  ATP-dependent RNA helicase activity  helicase activity  protein binding  ATP binding  nuclear pore  cytoplasm  mRNA export from nucleus  RNA splicing  regulation of gene expression  RNA secondary structure unwinding  membrane  nuclear membrane  extracellular exosome  catalytic step 2 spliceosome  
Ontology : EGO-EBIRNA binding  ATP-dependent RNA helicase activity  helicase activity  protein binding  ATP binding  nuclear pore  cytoplasm  mRNA export from nucleus  RNA splicing  regulation of gene expression  RNA secondary structure unwinding  membrane  nuclear membrane  extracellular exosome  catalytic step 2 spliceosome  
NDEx NetworkDDX19B
Atlas of Cancer Signalling NetworkDDX19B
Wikipedia pathwaysDDX19B
Orthology - Evolution
OrthoDB11269
GeneTree (enSembl)ENSG00000157349
Phylogenetic Trees/Animal Genes : TreeFamDDX19B
HOVERGENQ9UMR2
HOGENOMQ9UMR2
Homologs : HomoloGeneDDX19B
Homology/Alignments : Family Browser (UCSC)DDX19B
Gene fusions - Rearrangements
Fusion : MitelmanDDX19B/KCTD19 [16q22.1/16q22.1]  
Fusion : MitelmanSF3B3/DDX19B [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion : MitelmanTGIF1/DDX19B [18p11.31/16q22.1]  [t(16;18)(q22;p11)]  
Fusion: TCGADDX19B 16q22.1 KCTD19 16q22.1 KIRC
Fusion: TCGASF3B3 16q22.1 DDX19B 16q22.1 BLCA GBM
Fusion: TCGATGIF1 18p11.31 DDX19B 16q22.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX19B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX19B
dbVarDDX19B
ClinVarDDX19B
1000_GenomesDDX19B 
Exome Variant ServerDDX19B
ExAC (Exome Aggregation Consortium)DDX19B (select the gene name)
Genetic variants : HAPMAP11269
Genomic Variants (DGV)DDX19B [DGVbeta]
DECIPHERDDX19B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX19B 
Mutations
ICGC Data PortalDDX19B 
TCGA Data PortalDDX19B 
Broad Tumor PortalDDX19B
OASIS PortalDDX19B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDDX19B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX19B
DgiDB (Drug Gene Interaction Database)DDX19B
DoCM (Curated mutations)DDX19B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX19B (select a term)
intoGenDDX19B
Cancer3DDDX19B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605812   
Orphanet
MedgenDDX19B
Genetic Testing Registry DDX19B
NextProtQ9UMR2 [Medical]
TSGene11269
GENETestsDDX19B
Target ValidationDDX19B
Huge Navigator DDX19B [HugePedia]
snp3D : Map Gene to Disease11269
BioCentury BCIQDDX19B
ClinGenDDX19B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11269
Chemical/Pharm GKB GenePA27208
Clinical trialDDX19B
Miscellaneous
canSAR (ICR)DDX19B (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDX19B
EVEXDDX19B
GoPubMedDDX19B
iHOPDDX19B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:59:20 CEST 2017

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