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DDX20 (DEAD-box helicase 20)

Identity

Alias (NCBI)DP103
GEMIN3
HGNC (Hugo) DDX20
HGNC Alias symbDP103
GEMIN3
HGNC Previous nameDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
LocusID (NCBI) 11218
Atlas_Id 47213
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 111755901 and ends at 111768000 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDX20 (1p13.2) / TBX15 (1p12)DDX20 1p13.2 / TBX15 1p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p12;p13) DDX20/TBX15


External links

Nomenclature
HGNC (Hugo)DDX20   2743
Cards
Entrez_Gene (NCBI)DDX20    DEAD-box helicase 20
AliasesDP103; GEMIN3
GeneCards (Weizmann)DDX20
Ensembl hg19 (Hinxton)ENSG00000064703 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000064703 [Gene_View]  ENSG00000064703 [Sequence]  chr1:111755901-111768000 [Contig_View]  DDX20 [Vega]
ICGC DataPortalENSG00000064703
TCGA cBioPortalDDX20
AceView (NCBI)DDX20
Genatlas (Paris)DDX20
SOURCE (Princeton)DDX20
Genetics Home Reference (NIH)DDX20
Genomic and cartography
GoldenPath hg38 (UCSC)DDX20  -     chr1:111755901-111768000 +  1p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX20  -     1p13.2   [Description]    (hg19-Feb_2009)
GoldenPathDDX20 - 1p13.2 [CytoView hg19]  DDX20 - 1p13.2 [CytoView hg38]
ImmunoBaseENSG00000064703
genome Data Viewer NCBIDDX20 [Mapview hg19]  
OMIM606168   
Gene and transcription
Genbank (Entrez)AF106019 AF155803 AF171063 AK001506 AK301697
RefSeq transcript (Entrez)NM_007204
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX20
Alternative Splicing GalleryENSG00000064703
Gene ExpressionDDX20 [ NCBI-GEO ]   DDX20 [ EBI - ARRAY_EXPRESS ]   DDX20 [ SEEK ]   DDX20 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX20 [ Firebrowse - Broad ]
GenevisibleExpression of DDX20 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11218
GTEX Portal (Tissue expression)DDX20
Human Protein AtlasENSG00000064703-DDX20 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHI6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHI6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHI6
Splice isoforms : SwissVarQ9UHI6
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UHI6
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX20
Blocks (Seattle)DDX20
PDB (RSDB)2OXC    3B7G   
PDB Europe2OXC    3B7G   
PDB (PDBSum)2OXC    3B7G   
PDB (IMB)2OXC    3B7G   
Structural Biology KnowledgeBase2OXC    3B7G   
SCOP (Structural Classification of Proteins)2OXC    3B7G   
CATH (Classification of proteins structures)2OXC    3B7G   
SuperfamilyQ9UHI6
Human Protein Atlas [tissue]ENSG00000064703-DDX20 [tissue]
Peptide AtlasQ9UHI6
HPRD05859
IPIIPI00005904   IPI00982671   IPI00982035   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHI6
IntAct (EBI)Q9UHI6
BioGRIDDDX20
STRING (EMBL)DDX20
ZODIACDDX20
Ontologies - Pathways
QuickGOQ9UHI6
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  spliceosomal tri-snRNP complex assembly  spliceosomal snRNP assembly  spliceosomal snRNP assembly  spliceosomal snRNP assembly  DNA binding  RNA binding  RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  cytoskeleton  RNA processing  negative regulation of cell proliferation  membrane  protein domain specific binding  protein binding, bridging  SMN complex  SMN complex  SMN-Sm protein complex  histone deacetylase binding  positive regulation of apoptotic process  positive regulation of apoptotic process  oogenesis  regulation of steroid biosynthetic process  import into nucleus  repressing transcription factor binding  RNA polymerase II transcription repressor complex  Gemini of coiled bodies  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  spliceosomal tri-snRNP complex assembly  spliceosomal snRNP assembly  spliceosomal snRNP assembly  spliceosomal snRNP assembly  DNA binding  RNA binding  RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  cytoskeleton  RNA processing  negative regulation of cell proliferation  membrane  protein domain specific binding  protein binding, bridging  SMN complex  SMN complex  SMN-Sm protein complex  histone deacetylase binding  positive regulation of apoptotic process  positive regulation of apoptotic process  oogenesis  regulation of steroid biosynthetic process  import into nucleus  repressing transcription factor binding  RNA polymerase II transcription repressor complex  Gemini of coiled bodies  
Pathways : KEGGRNA transport   
NDEx NetworkDDX20
Atlas of Cancer Signalling NetworkDDX20
Wikipedia pathwaysDDX20
Orthology - Evolution
OrthoDB11218
GeneTree (enSembl)ENSG00000064703
Phylogenetic Trees/Animal Genes : TreeFamDDX20
HOGENOMQ9UHI6
Homologs : HomoloGeneDDX20
Homology/Alignments : Family Browser (UCSC)DDX20
Gene fusions - Rearrangements
Fusion : MitelmanDDX20/TBX15 [1p13.2/1p12]  
Fusion PortalDDX20 1p13.2 TBX15 1p12 LAML
Fusion : QuiverDDX20
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX20 [hg38]
dbVarDDX20
ClinVarDDX20
MonarchDDX20
1000_GenomesDDX20 
Exome Variant ServerDDX20
GNOMAD BrowserENSG00000064703
Varsome BrowserDDX20
Genomic Variants (DGV)DDX20 [DGVbeta]
DECIPHERDDX20 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX20 
Mutations
ICGC Data PortalDDX20 
TCGA Data PortalDDX20 
Broad Tumor PortalDDX20
OASIS PortalDDX20 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX20  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDX20
Mutations and Diseases : HGMDDDX20
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX20
DgiDB (Drug Gene Interaction Database)DDX20
DoCM (Curated mutations)DDX20 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX20 (select a term)
intoGenDDX20
Cancer3DDDX20(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606168   
Orphanet
DisGeNETDDX20
MedgenDDX20
Genetic Testing Registry DDX20
NextProtQ9UHI6 [Medical]
GENETestsDDX20
Target ValidationDDX20
Huge Navigator DDX20 [HugePedia]
ClinGenDDX20
Clinical trials, drugs, therapy
MyCancerGenomeDDX20
Protein Interactions : CTD
Pharm GKB GenePA27209
PharosQ9UHI6
Clinical trialDDX20
Miscellaneous
canSAR (ICR)DDX20 (select the gene name)
HarmonizomeDDX20
DataMed IndexDDX20
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDDX20
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:12:34 CET 2021

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