Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DDX27 (DEAD-box helicase 27)


Alias_namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Alias_symbol (synonym)dJ686N3.1
Other aliasDrs1p
HGNC (Hugo) DDX27
LocusID (NCBI) 55661
Atlas_Id 47232
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 49219295 and ends at 49244077 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABL1 (9q34.12) / DDX27 (20q13.13)ADNP (20q13.13) / DDX27 (20q13.13)COL6A2 (21q22.3) / DDX27 (20q13.13)
COX6C (8q22.2) / DDX27 (20q13.13)CSDE1 (1p13.2) / DDX27 (20q13.13)CTTN (11q13.3) / DDX27 (20q13.13)
DDX27 (20q13.13) / DDX27 (20q13.13)DDX27 (20q13.13) / EIF6 (20q11.22)DDX27 (20q13.13) / PLXNA2 (1q32.2)
GLUL (1q25.3) / DDX27 (20q13.13)GPNMB (7p15.3) / DDX27 (20q13.13)GSN (9q33.2) / DDX27 (20q13.13)
HDLBP (2q37.3) / DDX27 (20q13.13)HSPH1 (13q12.3) / DDX27 (20q13.13)LONP1 (19p13.3) / DDX27 (20q13.13)
MTSS1 (8q24.13) / DDX27 (20q13.13)MXRA8 (1p36.33) / DDX27 (20q13.13)NCOR2 (12q24.31) / DDX27 (20q13.13)
PERP (6q23.3) / DDX27 (20q13.13)SAMHD1 (20q11.23) / DDX27 (20q13.13)SLC25A3 (12q23.1) / DDX27 (20q13.13)
STOM (9q33.2) / DDX27 (20q13.13)VEGFA (6p21.1) / DDX27 (20q13.13)ABL1 9q34.12 / DDX27 20q13.13
ADNP 20q13.13 / DDX27 20q13.13COL6A2 21q22.3 / DDX27 20q13.13COX6C 8q22.2 / DDX27 20q13.13
CSDE1 1p13.2 / DDX27 20q13.13CTTN 11q13.3 / DDX27 20q13.13GLUL 1q25.3 / DDX27 20q13.13
GPNMB 7p15.3 / DDX27 20q13.13GSN 9q33.2 / DDX27 20q13.13HDLBP 2q37.3 / DDX27 20q13.13
HSPH1 13q12.3 / DDX27 20q13.13LONP1 19p13.3 / DDX27 20q13.13MTSS1 8q24.13 / DDX27 20q13.13
MXRA8 1p36.33 / DDX27 20q13.13NCOR2 12q24.31 / DDX27 20q13.13PERP 6q23.3 / DDX27 20q13.13
SAMHD1 20q11.23 / DDX27 20q13.13SLC25A3 12q23.1 / DDX27 20q13.13STOM 9q33.2 / DDX27 20q13.13
VEGFA 6p21.1 / DDX27 20q13.13


Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 20 ]

Solid Tumors TT_t0120p13q13ID104326 TT_t0120p36q13ID104336 TT_t0120q25q13ID104340 TT_t0220q37q13ID105413 TT_t0620p21q13ID107001
TT_t0620q23q13ID107005 TT_t0720p15q13ID107494 TT_t0820q22q13ID107972 TT_t0820q24q13ID107976 TT_t0920q33q13ID108375
TT_t0920q33q13ID108376 TT_t0920q34q13ID108378 TT_t1120q13q13ID101064 TT_t1220q23q13ID101570 TT_t1220q24q13ID101573
TT_t1320q12q13ID101689 TT_t1920p13q13ID103467 TT_t2020q11q13ID104667 TT_t2020q13q13ID104681 TT_t2021q13q22ID104737

External links

HGNC (Hugo)DDX27   15837
Entrez_Gene (NCBI)DDX27  55661  DEAD-box helicase 27
AliasesDRS1; Drs1p; HSPC259; PP3241; 
RHLP; dJ686N3.1
GeneCards (Weizmann)DDX27
Ensembl hg19 (Hinxton)ENSG00000124228 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124228 [Gene_View]  ENSG00000124228 [Sequence]  chr20:49219295-49244077 [Contig_View]  DDX27 [Vega]
ICGC DataPortalENSG00000124228
TCGA cBioPortalDDX27
AceView (NCBI)DDX27
Genatlas (Paris)DDX27
SOURCE (Princeton)DDX27
Genetics Home Reference (NIH)DDX27
Genomic and cartography
GoldenPath hg38 (UCSC)DDX27  -     chr20:49219295-49244077 +  20q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX27  -     20q13.13   [Description]    (hg19-Feb_2009)
GoldenPathDDX27 - 20q13.13 [CytoView hg19]  DDX27 - 20q13.13 [CytoView hg38]
Mapping of homologs : NCBIDDX27 [Mapview hg19]  DDX27 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF193054 AF336851 AK000603 AK022979 AK025891
RefSeq transcript (Entrez)NM_001348187 NM_017895
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX27
Cluster EST : UnigeneHs.65234 [ NCBI ]
CGAP (NCI)Hs.65234
Alternative Splicing GalleryENSG00000124228
Gene ExpressionDDX27 [ NCBI-GEO ]   DDX27 [ EBI - ARRAY_EXPRESS ]   DDX27 [ SEEK ]   DDX27 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX27 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55661
GTEX Portal (Tissue expression)DDX27
Human Protein AtlasENSG00000124228-DDX27 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96GQ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96GQ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96GQ7
Splice isoforms : SwissVarQ96GQ7
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX27
DMDM Disease mutations55661
Blocks (Seattle)DDX27
Human Protein Atlas [tissue]ENSG00000124228-DDX27 [tissue]
Peptide AtlasQ96GQ7
IPIIPI00293078   IPI01011137   
Protein Interaction databases
IntAct (EBI)Q96GQ7
Ontologies - Pathways
Ontology : AmiGORNA binding  RNA binding  RNA helicase activity  RNA helicase activity  protein binding  ATP binding  chromosome  nucleolus  nucleolus  rRNA processing  rRNA processing  
Ontology : EGO-EBIRNA binding  RNA binding  RNA helicase activity  RNA helicase activity  protein binding  ATP binding  chromosome  nucleolus  nucleolus  rRNA processing  rRNA processing  
NDEx NetworkDDX27
Atlas of Cancer Signalling NetworkDDX27
Wikipedia pathwaysDDX27
Orthology - Evolution
GeneTree (enSembl)ENSG00000124228
Phylogenetic Trees/Animal Genes : TreeFamDDX27
Homologs : HomoloGeneDDX27
Homology/Alignments : Family Browser (UCSC)DDX27
Gene fusions - Rearrangements
Fusion : MitelmanABL1/DDX27 [9q34.12/20q13.13]  [t(9;20)(q34;q13)]  
Fusion : MitelmanADNP/DDX27 [20q13.13/20q13.13]  [t(20;20)(q13;q13)]  
Fusion : MitelmanCOL6A2/DDX27 [21q22.3/20q13.13]  [t(20;21)(q13;q22)]  
Fusion : MitelmanCOX6C/DDX27 [8q22.2/20q13.13]  [t(8;20)(q22;q13)]  
Fusion : MitelmanCSDE1/DDX27 [1p13.2/20q13.13]  [t(1;20)(p13;q13)]  
Fusion : MitelmanCTTN/DDX27 [11q13.3/20q13.13]  [t(11;20)(q13;q13)]  
Fusion : MitelmanGLUL/DDX27 [1q25.3/20q13.13]  [t(1;20)(q25;q13)]  
Fusion : MitelmanGPNMB/DDX27 [7p15.3/20q13.13]  [t(7;20)(p15;q13)]  
Fusion : MitelmanGSN/DDX27 [9q33.2/20q13.13]  [t(9;20)(q33;q13)]  
Fusion : MitelmanHDLBP/DDX27 [2q37.3/20q13.13]  [t(2;20)(q37;q13)]  
Fusion : MitelmanHSPH1/DDX27 [13q12.3/20q13.13]  [t(13;20)(q12;q13)]  
Fusion : MitelmanLONP1/DDX27 [19p13.3/20q13.13]  [t(19;20)(p13;q13)]  
Fusion : MitelmanMTSS1/DDX27 [8q24.13/20q13.13]  [t(8;20)(q24;q13)]  
Fusion : MitelmanMXRA8/DDX27 [1p36.33/20q13.13]  [t(1;20)(p36;q13)]  
Fusion : MitelmanNCOR2/DDX27 [12q24.31/20q13.13]  [t(12;20)(q24;q13)]  
Fusion : MitelmanPERP/DDX27 [6q23.3/20q13.13]  [t(6;20)(q23;q13)]  
Fusion : MitelmanSAMHD1/DDX27 [20q11.23/20q13.13]  [t(20;20)(q11;q13)]  
Fusion : MitelmanSLC25A3/DDX27 [12q23.1/20q13.13]  [t(12;20)(q23;q13)]  
Fusion : MitelmanSTOM/DDX27 [9q33.2/20q13.13]  [t(9;20)(q33;q13)]  
Fusion : MitelmanVEGFA/DDX27 [6p21.1/20q13.13]  [t(6;20)(p21;q13)]  
Fusion PortalABL1 9q34.12 DDX27 20q13.13 BLCA
Fusion PortalADNP 20q13.13 DDX27 20q13.13 LUAD
Fusion PortalCOL6A2 21q22.3 DDX27 20q13.13 BLCA
Fusion PortalCOX6C 8q22.2 DDX27 20q13.13 BRCA
Fusion PortalCSDE1 1p13.2 DDX27 20q13.13 LUAD
Fusion PortalCTTN 11q13.3 DDX27 20q13.13 BLCA
Fusion PortalGLUL 1q25.3 DDX27 20q13.13 BRCA
Fusion PortalGPNMB 7p15.3 DDX27 20q13.13 SKCM
Fusion PortalGSN 9q33.2 DDX27 20q13.13 HNSC
Fusion PortalHDLBP 2q37.3 DDX27 20q13.13 PRAD
Fusion PortalHSPH1 13q12.3 DDX27 20q13.13 LGG
Fusion PortalLONP1 19p13.3 DDX27 20q13.13 LUAD
Fusion PortalMTSS1 8q24.13 DDX27 20q13.13 KIRC
Fusion PortalMXRA8 1p36.33 DDX27 20q13.13 BLCA
Fusion PortalNCOR2 12q24.31 DDX27 20q13.13 HNSC
Fusion PortalPERP 6q23.3 DDX27 20q13.13 LUSC
Fusion PortalSAMHD1 20q11.23 DDX27 20q13.13 BRCA
Fusion PortalSLC25A3 12q23.1 DDX27 20q13.13 SKCM
Fusion PortalSTOM 9q33.2 DDX27 20q13.13 BRCA
Fusion PortalVEGFA 6p21.1 DDX27 20q13.13 KIRC
Fusion : QuiverDDX27
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX27
Exome Variant ServerDDX27
ExAC (Exome Aggregation Consortium)ENSG00000124228
GNOMAD BrowserENSG00000124228
Varsome BrowserDDX27
Genetic variants : HAPMAP55661
Genomic Variants (DGV)DDX27 [DGVbeta]
DECIPHERDDX27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX27 
ICGC Data PortalDDX27 
TCGA Data PortalDDX27 
Broad Tumor PortalDDX27
OASIS PortalDDX27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX27  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDX27
Mutations and Diseases : HGMDDDX27
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX27
DgiDB (Drug Gene Interaction Database)DDX27
DoCM (Curated mutations)DDX27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX27 (select a term)
Cancer3DDDX27(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry DDX27
NextProtQ96GQ7 [Medical]
Target ValidationDDX27
Huge Navigator DDX27 [HugePedia]
snp3D : Map Gene to Disease55661
BioCentury BCIQDDX27
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55661
Chemical/Pharm GKB GenePA27213
Clinical trialDDX27
canSAR (ICR)DDX27 (select the gene name)
DataMed IndexDDX27
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Feb 3 14:55:25 CET 2020

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