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DDX27 (DEAD-box helicase 27)

Identity

Alias_namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Alias_symbol (synonym)dJ686N3.1
DRS1
Other aliasDrs1p
HSPC259
PP3241
RHLP
HGNC (Hugo) DDX27
LocusID (NCBI) 55661
Atlas_Id 47232
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 49219295 and ends at 49244077 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABL1 (9q34.12) / DDX27 (20q13.13)ADNP (20q13.13) / DDX27 (20q13.13)COL6A2 (21q22.3) / DDX27 (20q13.13)
COX6C (8q22.2) / DDX27 (20q13.13)CSDE1 (1p13.2) / DDX27 (20q13.13)CTTN (11q13.3) / DDX27 (20q13.13)
DDX27 (20q13.13) / DDX27 (20q13.13)DDX27 (20q13.13) / EIF6 (20q11.22)DDX27 (20q13.13) / PLXNA2 (1q32.2)
GLUL (1q25.3) / DDX27 (20q13.13)GPNMB (7p15.3) / DDX27 (20q13.13)GSN (9q33.2) / DDX27 (20q13.13)
HDLBP (2q37.3) / DDX27 (20q13.13)HSPH1 (13q12.3) / DDX27 (20q13.13)LONP1 (19p13.3) / DDX27 (20q13.13)
MTSS1 (8q24.13) / DDX27 (20q13.13)MXRA8 (1p36.33) / DDX27 (20q13.13)NCOR2 (12q24.31) / DDX27 (20q13.13)
PERP (6q23.3) / DDX27 (20q13.13)SAMHD1 (20q11.23) / DDX27 (20q13.13)SLC25A3 (12q23.1) / DDX27 (20q13.13)
STOM (9q33.2) / DDX27 (20q13.13)VEGFA (6p21.1) / DDX27 (20q13.13)ABL1 9q34.12 / DDX27 20q13.13
ADNP 20q13.13 / DDX27 20q13.13COL6A2 21q22.3 / DDX27 20q13.13COX6C 8q22.2 / DDX27 20q13.13
CSDE1 1p13.2 / DDX27 20q13.13CTTN 11q13.3 / DDX27 20q13.13GLUL 1q25.3 / DDX27 20q13.13
GPNMB 7p15.3 / DDX27 20q13.13GSN 9q33.2 / DDX27 20q13.13HDLBP 2q37.3 / DDX27 20q13.13
HSPH1 13q12.3 / DDX27 20q13.13LONP1 19p13.3 / DDX27 20q13.13MTSS1 8q24.13 / DDX27 20q13.13
MXRA8 1p36.33 / DDX27 20q13.13NCOR2 12q24.31 / DDX27 20q13.13PERP 6q23.3 / DDX27 20q13.13
SAMHD1 20q11.23 / DDX27 20q13.13SLC25A3 12q23.1 / DDX27 20q13.13STOM 9q33.2 / DDX27 20q13.13
VEGFA 6p21.1 / DDX27 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DDX27   15837
Cards
Entrez_Gene (NCBI)DDX27  55661  DEAD-box helicase 27
AliasesDRS1; Drs1p; HSPC259; PP3241; 
RHLP; dJ686N3.1
GeneCards (Weizmann)DDX27
Ensembl hg19 (Hinxton)ENSG00000124228 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124228 [Gene_View]  chr20:49219295-49244077 [Contig_View]  DDX27 [Vega]
ICGC DataPortalENSG00000124228
TCGA cBioPortalDDX27
AceView (NCBI)DDX27
Genatlas (Paris)DDX27
WikiGenes55661
SOURCE (Princeton)DDX27
Genetics Home Reference (NIH)DDX27
Genomic and cartography
GoldenPath hg38 (UCSC)DDX27  -     chr20:49219295-49244077 +  20q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX27  -     20q13.13   [Description]    (hg19-Feb_2009)
EnsemblDDX27 - 20q13.13 [CytoView hg19]  DDX27 - 20q13.13 [CytoView hg38]
Mapping of homologs : NCBIDDX27 [Mapview hg19]  DDX27 [Mapview hg38]
OMIM616621   
Gene and transcription
Genbank (Entrez)AF193054 AF336851 AK000603 AK022979 AK025891
RefSeq transcript (Entrez)NM_001348187 NM_017895
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX27
Cluster EST : UnigeneHs.65234 [ NCBI ]
CGAP (NCI)Hs.65234
Alternative Splicing GalleryENSG00000124228
Gene ExpressionDDX27 [ NCBI-GEO ]   DDX27 [ EBI - ARRAY_EXPRESS ]   DDX27 [ SEEK ]   DDX27 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX27 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55661
GTEX Portal (Tissue expression)DDX27
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96GQ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96GQ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96GQ7
Splice isoforms : SwissVarQ96GQ7
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ96GQ7
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX27
DMDM Disease mutations55661
Blocks (Seattle)DDX27
SuperfamilyQ96GQ7
Human Protein AtlasENSG00000124228
Peptide AtlasQ96GQ7
HPRD10859
IPIIPI00293078   IPI01011137   
Protein Interaction databases
DIP (DOE-UCLA)Q96GQ7
IntAct (EBI)Q96GQ7
FunCoupENSG00000124228
BioGRIDDDX27
STRING (EMBL)DDX27
ZODIACDDX27
Ontologies - Pathways
QuickGOQ96GQ7
Ontology : AmiGORNA binding  ATP-dependent RNA helicase activity  protein binding  ATP binding  chromosome  nucleolus  rRNA processing  RNA secondary structure unwinding  
Ontology : EGO-EBIRNA binding  ATP-dependent RNA helicase activity  protein binding  ATP binding  chromosome  nucleolus  rRNA processing  RNA secondary structure unwinding  
NDEx NetworkDDX27
Atlas of Cancer Signalling NetworkDDX27
Wikipedia pathwaysDDX27
Orthology - Evolution
OrthoDB55661
GeneTree (enSembl)ENSG00000124228
Phylogenetic Trees/Animal Genes : TreeFamDDX27
HOVERGENQ96GQ7
HOGENOMQ96GQ7
Homologs : HomoloGeneDDX27
Homology/Alignments : Family Browser (UCSC)DDX27
Gene fusions - Rearrangements
Fusion : MitelmanABL1/DDX27 [9q34.12/20q13.13]  [t(9;20)(q34;q13)]  
Fusion : MitelmanADNP/DDX27 [20q13.13/20q13.13]  [t(20;20)(q13;q13)]  
Fusion : MitelmanCOL6A2/DDX27 [21q22.3/20q13.13]  [t(20;21)(q13;q22)]  
Fusion : MitelmanCOX6C/DDX27 [8q22.2/20q13.13]  [t(8;20)(q22;q13)]  
Fusion : MitelmanCSDE1/DDX27 [1p13.2/20q13.13]  [t(1;20)(p13;q13)]  
Fusion : MitelmanCTTN/DDX27 [11q13.3/20q13.13]  [t(11;20)(q13;q13)]  
Fusion : MitelmanGLUL/DDX27 [1q25.3/20q13.13]  [t(1;20)(q25;q13)]  
Fusion : MitelmanGPNMB/DDX27 [7p15.3/20q13.13]  [t(7;20)(p15;q13)]  
Fusion : MitelmanGSN/DDX27 [9q33.2/20q13.13]  [t(9;20)(q33;q13)]  
Fusion : MitelmanHDLBP/DDX27 [2q37.3/20q13.13]  [t(2;20)(q37;q13)]  
Fusion : MitelmanHSPH1/DDX27 [13q12.3/20q13.13]  [t(13;20)(q12;q13)]  
Fusion : MitelmanLONP1/DDX27 [19p13.3/20q13.13]  [t(19;20)(p13;q13)]  
Fusion : MitelmanMTSS1/DDX27 [8q24.13/20q13.13]  [t(8;20)(q24;q13)]  
Fusion : MitelmanMXRA8/DDX27 [1p36.33/20q13.13]  [t(1;20)(p36;q13)]  
Fusion : MitelmanNCOR2/DDX27 [12q24.31/20q13.13]  [t(12;20)(q24;q13)]  
Fusion : MitelmanPERP/DDX27 [6q23.3/20q13.13]  [t(6;20)(q23;q13)]  
Fusion : MitelmanSAMHD1/DDX27 [20q11.23/20q13.13]  [t(20;20)(q11;q13)]  
Fusion : MitelmanSLC25A3/DDX27 [12q23.1/20q13.13]  [t(12;20)(q23;q13)]  
Fusion : MitelmanSTOM/DDX27 [9q33.2/20q13.13]  [t(9;20)(q33;q13)]  
Fusion : MitelmanVEGFA/DDX27 [6p21.1/20q13.13]  [t(6;20)(p21;q13)]  
Fusion: TCGAABL1 9q34.12 DDX27 20q13.13 BLCA
Fusion: TCGAADNP 20q13.13 DDX27 20q13.13 LUAD
Fusion: TCGACOL6A2 21q22.3 DDX27 20q13.13 BLCA
Fusion: TCGACOX6C 8q22.2 DDX27 20q13.13 BRCA
Fusion: TCGACSDE1 1p13.2 DDX27 20q13.13 LUAD
Fusion: TCGACTTN 11q13.3 DDX27 20q13.13 BLCA
Fusion: TCGAGLUL 1q25.3 DDX27 20q13.13 BRCA
Fusion: TCGAGPNMB 7p15.3 DDX27 20q13.13 SKCM
Fusion: TCGAGSN 9q33.2 DDX27 20q13.13 HNSC
Fusion: TCGAHDLBP 2q37.3 DDX27 20q13.13 PRAD
Fusion: TCGAHSPH1 13q12.3 DDX27 20q13.13 LGG
Fusion: TCGALONP1 19p13.3 DDX27 20q13.13 LUAD
Fusion: TCGAMTSS1 8q24.13 DDX27 20q13.13 KIRC
Fusion: TCGAMXRA8 1p36.33 DDX27 20q13.13 BLCA
Fusion: TCGANCOR2 12q24.31 DDX27 20q13.13 HNSC
Fusion: TCGAPERP 6q23.3 DDX27 20q13.13 LUSC
Fusion: TCGASAMHD1 20q11.23 DDX27 20q13.13 BRCA
Fusion: TCGASLC25A3 12q23.1 DDX27 20q13.13 SKCM
Fusion: TCGASTOM 9q33.2 DDX27 20q13.13 BRCA
Fusion: TCGAVEGFA 6p21.1 DDX27 20q13.13 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX27
dbVarDDX27
ClinVarDDX27
1000_GenomesDDX27 
Exome Variant ServerDDX27
ExAC (Exome Aggregation Consortium)DDX27 (select the gene name)
Genetic variants : HAPMAP55661
Genomic Variants (DGV)DDX27 [DGVbeta]
DECIPHERDDX27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX27 
Mutations
ICGC Data PortalDDX27 
TCGA Data PortalDDX27 
Broad Tumor PortalDDX27
OASIS PortalDDX27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX27  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDX27
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX27
DgiDB (Drug Gene Interaction Database)DDX27
DoCM (Curated mutations)DDX27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX27 (select a term)
intoGenDDX27
Cancer3DDDX27(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616621   
Orphanet
MedgenDDX27
Genetic Testing Registry DDX27
NextProtQ96GQ7 [Medical]
TSGene55661
GENETestsDDX27
Target ValidationDDX27
Huge Navigator DDX27 [HugePedia]
snp3D : Map Gene to Disease55661
BioCentury BCIQDDX27
ClinGenDDX27
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55661
Chemical/Pharm GKB GenePA27213
Clinical trialDDX27
Miscellaneous
canSAR (ICR)DDX27 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDX27
EVEXDDX27
GoPubMedDDX27
iHOPDDX27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:59:20 CEST 2017

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