Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DDX3X (DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked)

Identity

Other namesDBX
DDX14
DDX3
HLP2
HGNC (Hugo) DDX3X
LocusID (NCBI) 1654
Location Xp11.4
Location_base_pair Starts at 41192651 and ends at 41209524 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DDX3X   2745
Entrez_Gene (NCBI)DDX3X  1654  DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
Cards
GeneCards (Weizmann)DDX3X
Ensembl (Hinxton)ENSG00000215301 [Gene_View]  chrX:41192651-41209524 [Contig_View]  DDX3X [Vega]
AceView (NCBI)DDX3X
Genatlas (Paris)DDX3X
SOURCE (Stanford)NM_001193416 NM_001193417 NM_001356 NM_024005
Genomic and cartography
GoldenPath (UCSC)DDX3X  -  Xp11.4   chrX:41192651-41209524 +  Xp11.4   [Description]    (hg19-Feb_2009)
EnsemblDDX3X - Xp11.4 [CytoView]
Mapping of homologs : NCBIDDX3X [Mapview]
OMIM300160   
Gene and transcription
Genbank (Entrez)AB208983 AB451220 AB451343 AF000982 AF000983
RefSeq transcript (SRS)NM_001193416 NM_001193417 NM_001356 NM_024005
RefSeq transcript (Entrez)NM_001193416 NM_001193417 NM_001356 NM_024005
RefSeq genomic (SRS)AC_000155 NC_000023 NC_018934 NG_012830 NT_079573 NW_001842361 NW_004078119
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_012830 NT_079573 NW_001842361 NW_004078119
Consensus coding sequences : CCDS (NCBI)DDX3X
Cluster EST : UnigeneHs.743263 [ SRS ] Hs.743263 [ NCBI ]
CGAP (NCI)Hs.743263
Alternative Splicing : Fast-db (Paris)GSHG0031469
Alternative Splicing GalleryENSG00000215301
Gene ExpressionDDX3X [ NCBI-GEO ]   DDX3X [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00571 (SRS) O00571 (Uniprot)
NextProtO00571
With graphics : InterProO00571
Splice isoforms : SwissVarO00571(Swissvar)
Domaine pattern : Prosite (SRS)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (SRS)DNA/RNA_helicase_DEAD/DEAH_N    Helicase_ATP-bd    Helicase_C    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domains : Interpro (EBI)DNA/RNA_helicase_DEAD/DEAH_N    Helicase_ATP-bd    Helicase_C    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Related proteins : CluSTrO00571
Domain families : Pfam (SRS)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
DMDM1654
Blocks (Seattle)O00571
PDB (SRS)2I4I    2JGN    3JRV   
PDB (PDBSum)2I4I    2JGN    3JRV   
PDB (IMB)2I4I    2JGN    3JRV   
PDB (RSDB)2I4I    2JGN    3JRV   
Human Protein AtlasENSG00000215301
HPRD02154
IPIIPI00215637   IPI00909282   IPI00910433   IPI00909544   IPI00984839   IPI00985384   
Protein Interaction databases
DIP (DOE-UCLA)O00571
IntAct (EBI)O00571
FunCoupENSG00000215301
REACTOMEDDX3X
Protein Interaction Database1654
BioGRIDDDX3X
InParanoidO00571
Interologous Interaction database O00571
IntegromeDBDDX3X
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DDX3X
SNP (GeneSNP Utah)DDX3X
SNP : HGBaseDDX3X
Genetic variants : HAPMAPDDX3X
Somatic Mutations in Cancer : COSMICDDX3X 
CONAN: Copy Number AnalysisDDX3X 
Mutations and Diseases : HGMDDDX3X
OMIM300160   
GENETests300160   
Disease Genetic AssociationDDX3X
Huge Navigator DDX3X [HugePedia]  DDX3X [HugeCancerGEM]
Genomic VariantsDDX3X  DDX3X [DGVbeta]
ClinVarDDX3X
snp3D : Map Gene to Disease1654
General knowledge
Homologs : HomoloGeneDDX3X
Homology/Alignments : Family Browser (UCSC)DDX3X
Phylogenetic Trees/Animal Genes : TreeFamDDX3X
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.13 [ Enzyme-SRS ]   3.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
Chemical/Protein Interactions : CTD1654
Chemical/Pharm GKB GenePA27216
Clinical trialDDX3X
Cancer Resource (Charite)ENSG00000215301
Ontology : AmiGODNA binding  RNA binding  ATP-dependent DNA helicase activity  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrial outer membrane  eukaryotic translation initiation factor 3 complex  ATP catabolic process  transcription, DNA-dependent  chromosome segregation  intracellular protein kinase cascade  transcription factor binding  poly(A) RNA binding  eukaryotic initiation factor 4E binding  extrinsic apoptotic signaling pathway via death domain receptors  response to virus  cytoplasmic stress granule  RNA secondary structure unwinding  nuclear speck  ATPase activity  negative regulation of translation  virus-host interaction  cytosolic small ribosomal subunit  positive regulation of cell growth  negative regulation of cell growth  negative regulation of protein complex assembly  translation initiation factor binding  positive regulation of interferon-beta production  stress granule assembly  RNA stem-loop binding  mature ribosome assembly  ribosomal small subunit binding  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  innate immune response  positive regulation of translation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of translational initiation  mRNA 5'-UTR binding  cellular response to arsenic-containing substance  cellular response to osmotic stress  positive regulation of chemokine (C-C motif) ligand 5 production  intrinsic apoptotic signaling pathway  positive regulation of G1/S transition of mitotic cell cycle  negative regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIDNA binding  RNA binding  ATP-dependent DNA helicase activity  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrial outer membrane  eukaryotic translation initiation factor 3 complex  ATP catabolic process  transcription, DNA-dependent  chromosome segregation  intracellular protein kinase cascade  transcription factor binding  poly(A) RNA binding  eukaryotic initiation factor 4E binding  extrinsic apoptotic signaling pathway via death domain receptors  response to virus  cytoplasmic stress granule  RNA secondary structure unwinding  nuclear speck  ATPase activity  negative regulation of translation  virus-host interaction  cytosolic small ribosomal subunit  positive regulation of cell growth  negative regulation of cell growth  negative regulation of protein complex assembly  translation initiation factor binding  positive regulation of interferon-beta production  stress granule assembly  RNA stem-loop binding  mature ribosome assembly  ribosomal small subunit binding  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  innate immune response  positive regulation of translation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of translational initiation  mRNA 5'-UTR binding  cellular response to arsenic-containing substance  cellular response to osmotic stress  positive regulation of chemokine (C-C motif) ligand 5 production  intrinsic apoptotic signaling pathway  positive regulation of G1/S transition of mitotic cell cycle  negative regulation of intrinsic apoptotic signaling pathway  
Other databases
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
PubGeneDDX3X
iHOPDDX3X
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:38:32 CEST 2013
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