DDX3Y (DEAD-box helicase 3 Y-linked)

2007-04-01  

Identity

HGNC
LOCATION
Yq11.221
LOCUSID
ALIAS
DBY
FUSION GENES

Other Information

Locus ID:

NCBI: 8653
MIM: 400010
HGNC: 2699
Ensembl: ENSG00000067048

Variants:

dbSNP: 8653
ClinVar: 8653
TCGA: ENSG00000067048
COSMIC: DDX3Y

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067048ENST00000336079O15523
ENSG00000067048ENST00000336079A0A024R9A4
ENSG00000067048ENST00000360160O15523
ENSG00000067048ENST00000360160A0A024R9A4
ENSG00000067048ENST00000440554C9J081
ENSG00000067048ENST00000454054C9J8G5

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150965392004Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation.56
119297962002The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease.30
153833282004Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation.26
182994502008DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells.23
264566242015DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs.13
178817212007Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis.12
117105232001Gene structure of the human DDX3 and chromosome mapping of its related sequences.11
217096062011Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation.11
261442142015DDX3Y, a Male-Specific Region of Y Chromosome Gene, May Modulate Neuronal Differentiation.11
224668632012AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.8

Citation

Dessen P

DDX3Y (DEAD-box helicase 3 Y-linked)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46904/ddx3y