Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DDX4 (DEAD-box helicase 4)

Identity

Alias_namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Alias_symbol (synonym)VASA
Other alias
HGNC (Hugo) DDX4
LocusID (NCBI) 54514
Atlas_Id 46735
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 55033845 and ends at 55112974 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KAT6B (10q22.2) / DDX4 (5q11.2)KAT6B 10q22.2 / DDX4 5q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Testis: Spermatocytic seminoma


External links

Nomenclature
HGNC (Hugo)DDX4   18700
Cards
Entrez_Gene (NCBI)DDX4  54514  DEAD-box helicase 4
AliasesVASA
GeneCards (Weizmann)DDX4
Ensembl hg19 (Hinxton)ENSG00000152670 [Gene_View]  chr5:55033845-55112974 [Contig_View]  DDX4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000152670 [Gene_View]  chr5:55033845-55112974 [Contig_View]  DDX4 [Vega]
ICGC DataPortalENSG00000152670
TCGA cBioPortalDDX4
AceView (NCBI)DDX4
Genatlas (Paris)DDX4
WikiGenes54514
SOURCE (Princeton)DDX4
Genetics Home Reference (NIH)DDX4
Genomic and cartography
GoldenPath hg19 (UCSC)DDX4  -     chr5:55033845-55112974 +  5q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DDX4  -     5q11.2   [Description]    (hg38-Dec_2013)
EnsemblDDX4 - 5q11.2 [CytoView hg19]  DDX4 - 5q11.2 [CytoView hg38]
Mapping of homologs : NCBIDDX4 [Mapview hg19]  DDX4 [Mapview hg38]
OMIM605281   
Gene and transcription
Genbank (Entrez)AF262962 AK093439 AK292417 AK308300 AL137462
RefSeq transcript (Entrez)NM_001142549 NM_001166533 NM_001166534 NM_019039 NM_024415
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929322
Consensus coding sequences : CCDS (NCBI)DDX4
Cluster EST : UnigeneHs.223581 [ NCBI ]
CGAP (NCI)Hs.223581
Alternative Splicing GalleryENSG00000152670
Gene ExpressionDDX4 [ NCBI-GEO ]   DDX4 [ EBI - ARRAY_EXPRESS ]   DDX4 [ SEEK ]   DDX4 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54514
GTEX Portal (Tissue expression)DDX4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQI0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQI0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQI0
Splice isoforms : SwissVarQ9NQI0
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ9NQI0
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX4
DMDM Disease mutations54514
Blocks (Seattle)DDX4
SuperfamilyQ9NQI0
Human Protein AtlasENSG00000152670
Peptide AtlasQ9NQI0
HPRD05593
IPIIPI00071483   IPI00456933   IPI00953956   IPI00964112   IPI00954025   IPI00963838   IPI00966042   IPI00966474   IPI00967314   IPI00984140   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQI0
IntAct (EBI)Q9NQI0
FunCoupENSG00000152670
BioGRIDDDX4
STRING (EMBL)DDX4
ZODIACDDX4
Ontologies - Pathways
QuickGOQ9NQI0
Ontology : AmiGOnucleic acid binding  ATP-dependent RNA helicase activity  ATP binding  cytoplasm  male meiosis  multicellular organism development  spermatogenesis  RNA secondary structure unwinding  cell differentiation  sperm motility  gene silencing by RNA  piRNA metabolic process  DNA methylation involved in gamete generation  P granule  perinuclear region of cytoplasm  pi-body  piP-body  
Ontology : EGO-EBInucleic acid binding  ATP-dependent RNA helicase activity  ATP binding  cytoplasm  male meiosis  multicellular organism development  spermatogenesis  RNA secondary structure unwinding  cell differentiation  sperm motility  gene silencing by RNA  piRNA metabolic process  DNA methylation involved in gamete generation  P granule  perinuclear region of cytoplasm  pi-body  piP-body  
NDEx NetworkDDX4
Atlas of Cancer Signalling NetworkDDX4
Wikipedia pathwaysDDX4
Orthology - Evolution
OrthoDB54514
GeneTree (enSembl)ENSG00000152670
Phylogenetic Trees/Animal Genes : TreeFamDDX4
HOVERGENQ9NQI0
HOGENOMQ9NQI0
Homologs : HomoloGeneDDX4
Homology/Alignments : Family Browser (UCSC)DDX4
Gene fusions - Rearrangements
Fusion : MitelmanKAT6B/DDX4 [10q22.2/5q11.2]  [t(5;10)(q11;q22)]  
Fusion: TCGAKAT6B 10q22.2 DDX4 5q11.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX4
dbVarDDX4
ClinVarDDX4
1000_GenomesDDX4 
Exome Variant ServerDDX4
ExAC (Exome Aggregation Consortium)DDX4 (select the gene name)
Genetic variants : HAPMAP54514
Genomic Variants (DGV)DDX4 [DGVbeta]
DECIPHER (Syndromes)5:55033845-55112974  ENSG00000152670
CONAN: Copy Number AnalysisDDX4 
Mutations
ICGC Data PortalDDX4 
TCGA Data PortalDDX4 
Broad Tumor PortalDDX4
OASIS PortalDDX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX4
DgiDB (Drug Gene Interaction Database)DDX4
DoCM (Curated mutations)DDX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX4 (select a term)
intoGenDDX4
Cancer3DDDX4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605281   
Orphanet
MedgenDDX4
Genetic Testing Registry DDX4
NextProtQ9NQI0 [Medical]
TSGene54514
GENETestsDDX4
Huge Navigator DDX4 [HugePedia]
snp3D : Map Gene to Disease54514
BioCentury BCIQDDX4
ClinGenDDX4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54514
Chemical/Pharm GKB GenePA38646
Clinical trialDDX4
Miscellaneous
canSAR (ICR)DDX4 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDX4
EVEXDDX4
GoPubMedDDX4
iHOPDDX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:02:58 CET 2017

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