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DDX4 (DEAD-box helicase 4)

Identity

Alias (NCBI)VASA
HGNC (Hugo) DDX4
HGNC Alias symbVASA
HGNC Previous nameDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
LocusID (NCBI) 54514
Atlas_Id 46735
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 55738061 and ends at 55817157 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KAT6B (10q22.2) / DDX4 (5q11.2)KAT6B 10q22.2 / DDX4 5q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DDX4   18700
Cards
Entrez_Gene (NCBI)DDX4    DEAD-box helicase 4
AliasesVASA
GeneCards (Weizmann)DDX4
Ensembl hg19 (Hinxton)ENSG00000152670 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152670 [Gene_View]  ENSG00000152670 [Sequence]  chr5:55738061-55817157 [Contig_View]  DDX4 [Vega]
ICGC DataPortalENSG00000152670
TCGA cBioPortalDDX4
AceView (NCBI)DDX4
Genatlas (Paris)DDX4
SOURCE (Princeton)DDX4
Genetics Home Reference (NIH)DDX4
Genomic and cartography
GoldenPath hg38 (UCSC)DDX4  -     chr5:55738061-55817157 +  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX4  -     5q11.2   [Description]    (hg19-Feb_2009)
GoldenPathDDX4 - 5q11.2 [CytoView hg19]  DDX4 - 5q11.2 [CytoView hg38]
ImmunoBaseENSG00000152670
Genome Data Viewer NCBIDDX4 [Mapview hg19]  
OMIM605281   
Gene and transcription
Genbank (Entrez)AF262962 AK093439 AK292417 AK308300 AL137462
RefSeq transcript (Entrez)NM_001142549 NM_001166533 NM_001166534 NM_019039 NM_024415
Consensus coding sequences : CCDS (NCBI)DDX4
Gene ExpressionDDX4 [ NCBI-GEO ]   DDX4 [ EBI - ARRAY_EXPRESS ]   DDX4 [ SEEK ]   DDX4 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX4 [ Firebrowse - Broad ]
GenevisibleExpression of DDX4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54514
GTEX Portal (Tissue expression)DDX4
Human Protein AtlasENSG00000152670-DDX4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQI0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQI0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQI0
PhosPhoSitePlusQ9NQI0
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX4
SuperfamilyQ9NQI0
AlphaFold pdb e-kbQ9NQI0   
Human Protein Atlas [tissue]ENSG00000152670-DDX4 [tissue]
HPRD05593
Protein Interaction databases
DIP (DOE-UCLA)Q9NQI0
IntAct (EBI)Q9NQI0
BioGRIDDDX4
STRING (EMBL)DDX4
ZODIACDDX4
Ontologies - Pathways
QuickGOQ9NQI0
Ontology : AmiGORNA binding  RNA helicase activity  ATP binding  nucleus  cytoplasm  male meiotic nuclear division  male meiosis I  multicellular organism development  gamete generation  spermatogenesis  negative regulation of transposition  cell differentiation  flagellated sperm motility  gene silencing by RNA  piRNA metabolic process  DNA methylation involved in gamete generation  P granule  perinuclear region of cytoplasm  pi-body  piP-body  ATP hydrolysis activity  piRNA biosynthetic process  
Ontology : EGO-EBIRNA binding  RNA helicase activity  ATP binding  nucleus  cytoplasm  male meiotic nuclear division  male meiosis I  multicellular organism development  gamete generation  spermatogenesis  negative regulation of transposition  cell differentiation  flagellated sperm motility  gene silencing by RNA  piRNA metabolic process  DNA methylation involved in gamete generation  P granule  perinuclear region of cytoplasm  pi-body  piP-body  ATP hydrolysis activity  piRNA biosynthetic process  
NDEx NetworkDDX4
Atlas of Cancer Signalling NetworkDDX4
Wikipedia pathwaysDDX4
Orthology - Evolution
OrthoDB54514
GeneTree (enSembl)ENSG00000152670
Phylogenetic Trees/Animal Genes : TreeFamDDX4
Homologs : HomoloGeneDDX4
Homology/Alignments : Family Browser (UCSC)DDX4
Gene fusions - Rearrangements
Fusion : MitelmanKAT6B/DDX4 [10q22.2/5q11.2]  
Fusion : QuiverDDX4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX4
dbVarDDX4
ClinVarDDX4
MonarchDDX4
1000_GenomesDDX4 
Exome Variant ServerDDX4
GNOMAD BrowserENSG00000152670
Varsome BrowserDDX4
ACMGDDX4 variants
VarityQ9NQI0
Genomic Variants (DGV)DDX4 [DGVbeta]
DECIPHERDDX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX4 
Mutations
ICGC Data PortalDDX4 
TCGA Data PortalDDX4 
Broad Tumor PortalDDX4
OASIS PortalDDX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDX4
Mutations and Diseases : HGMDDDX4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDDX4
DgiDB (Drug Gene Interaction Database)DDX4
DoCM (Curated mutations)DDX4
CIViC (Clinical Interpretations of Variants in Cancer)DDX4
Cancer3DDDX4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605281   
Orphanet
DisGeNETDDX4
MedgenDDX4
Genetic Testing Registry DDX4
NextProtQ9NQI0 [Medical]
GENETestsDDX4
Target ValidationDDX4
Huge Navigator DDX4 [HugePedia]
ClinGenDDX4
Clinical trials, drugs, therapy
MyCancerGenomeDDX4
Protein Interactions : CTDDDX4
Pharm GKB GenePA38646
PharosQ9NQI0
Clinical trialDDX4
Miscellaneous
canSAR (ICR)DDX4
HarmonizomeDDX4
DataMed IndexDDX4
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDDX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:06:24 CEST 2021

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