DDX4 (DEAD-box helicase 4)

2007-04-01  

Identity

HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
VASA
FUSION GENES

Other Information

Locus ID:

NCBI: 54514
MIM: 605281
HGNC: 18700
Ensembl: ENSG00000152670

Variants:

dbSNP: 54514
ClinVar: 54514
TCGA: ENSG00000152670
COSMIC: DDX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152670ENST00000353507Q9NQI0
ENSG00000152670ENST00000354991Q9NQI0
ENSG00000152670ENST00000503129H0Y960
ENSG00000152670ENST00000505374Q9NQI0
ENSG00000152670ENST00000506511D6RCM4
ENSG00000152670ENST00000506848D6RAF5
ENSG00000152670ENST00000507645H0YBW0
ENSG00000152670ENST00000511491D6RIB2
ENSG00000152670ENST00000511853Q9NQI0
ENSG00000152670ENST00000514278Q9NQI0
ENSG00000152670ENST00000514679D6RBL3
ENSG00000152670ENST00000515709D6RAT7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
PIWI-interacting RNA (piRNA) biogenesisREACTOMER-HSA-5601884

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
257476592015Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles.285
221623802012Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro.48
188055762008Germ cell specific protein VASA is over-expressed in epithelial ovarian cancer and disrupts DNA damage-induced G2 checkpoint.17
247274492014DDX4 (DEAD box polypeptide 4) colocalizes with cancer stem cell marker CD133 in ovarian cancers.14
297250362018Initial characterisation of adult human ovarian cell populations isolated by DDX4 expression and aldehyde dehydrogenase activity.14
185349942008The developing human ovary: immunohistochemical analysis of germ-cell-specific VASA protein, BCL-2/BAX expression balance and apoptosis.13
199377542010Expression of GFP under the control of the RNA helicase VASA permits fluorescence-activated cell sorting isolation of human primordial germ cells.9
233150642013The infant and pubertal human ovary: Balbiani's body-associated VASA expression, immunohistochemical detection of apoptosis-related BCL2 and BAX proteins, and DNA fragmentation.8
118505292002VASA is a specific marker for both normal and malignant human germ cells.7
196291402009Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis.7

Citation

Dessen P

DDX4 (DEAD-box helicase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46735/ddx4