Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DDX41 (DEAD-box helicase 41)

Identity

Alias (NCBI)ABS
MPLPF
HGNC (Hugo) DDX41
HGNC Alias symbABS
MGC8828
HGNC Previous nameDEAD (Asp-Glu-Ala-Asp) box polypeptide 41
LocusID (NCBI) 51428
Atlas_Id 46682
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 177511577 and ends at 177516961 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDX41 (5q35.3)::MBP (18q23)JUP (17q21.2)::DDX41 (5q35.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Therapy-Related Hematopoietic Neoplasia


External links

 

Nomenclature
HGNC (Hugo)DDX41   18674
LRG (Locus Reference Genomic)LRG_1386
Cards
Entrez_Gene (NCBI)DDX41    DEAD-box helicase 41
AliasesABS; MPLPF
GeneCards (Weizmann)DDX41
Ensembl hg19 (Hinxton)ENSG00000183258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183258 [Gene_View]  ENSG00000183258 [Sequence]  chr5:177511577-177516961 [Contig_View]  DDX41 [Vega]
ICGC DataPortalENSG00000183258
TCGA cBioPortalDDX41
AceView (NCBI)DDX41
Genatlas (Paris)DDX41
SOURCE (Princeton)DDX41
Genetics Home Reference (NIH)DDX41
Genomic and cartography
GoldenPath hg38 (UCSC)DDX41  -     chr5:177511577-177516961 -  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX41  -     5q35.3   [Description]    (hg19-Feb_2009)
GoldenPathDDX41 - 5q35.3 [CytoView hg19]  DDX41 - 5q35.3 [CytoView hg38]
ImmunoBaseENSG00000183258
Genome Data Viewer NCBIDDX41 [Mapview hg19]  
OMIM608170   616871   
Gene and transcription
Genbank (Entrez)AF195417 AK001255 AK026117 AK027768 AK091545
RefSeq transcript (Entrez)NM_001321732 NM_001321830 NM_016222
Consensus coding sequences : CCDS (NCBI)DDX41
Gene ExpressionDDX41 [ NCBI-GEO ]   DDX41 [ EBI - ARRAY_EXPRESS ]   DDX41 [ SEEK ]   DDX41 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX41 [ Firebrowse - Broad ]
GenevisibleExpression of DDX41 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51428
GTEX Portal (Tissue expression)DDX41
Human Protein AtlasENSG00000183258-DDX41 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJV9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJV9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJV9
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UJV9
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DEADc_DDX41    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX41
PDB (RSDB)2P6N    5GVR    5GVS    5H1Y   
PDB Europe2P6N    5GVR    5GVS    5H1Y   
PDB (PDBSum)2P6N    5GVR    5GVS    5H1Y   
PDB (IMB)2P6N    5GVR    5GVS    5H1Y   
Structural Biology KnowledgeBase2P6N    5GVR    5GVS    5H1Y   
SCOP (Structural Classification of Proteins)2P6N    5GVR    5GVS    5H1Y   
CATH (Classification of proteins structures)2P6N    5GVR    5GVS    5H1Y   
SuperfamilyQ9UJV9
AlphaFold pdb e-kbQ9UJV9   
Human Protein Atlas [tissue]ENSG00000183258-DDX41 [tissue]
HPRD10490
Protein Interaction databases
DIP (DOE-UCLA)Q9UJV9
IntAct (EBI)Q9UJV9
BioGRIDDDX41
STRING (EMBL)DDX41
ZODIACDDX41
Ontologies - Pathways
QuickGOQ9UJV9
Ontology : AmiGOmRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  RNA binding  RNA helicase activity  protein binding  ATP binding  nucleus  spliceosomal complex  cytosol  apoptotic process  cell population proliferation  membrane  ATP hydrolysis activity  cell differentiation  metal ion binding  catalytic step 2 spliceosome  
Ontology : EGO-EBImRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  RNA binding  RNA helicase activity  protein binding  ATP binding  nucleus  spliceosomal complex  cytosol  apoptotic process  cell population proliferation  membrane  ATP hydrolysis activity  cell differentiation  metal ion binding  catalytic step 2 spliceosome  
NDEx NetworkDDX41
Atlas of Cancer Signalling NetworkDDX41
Wikipedia pathwaysDDX41
Orthology - Evolution
OrthoDB51428
GeneTree (enSembl)ENSG00000183258
Phylogenetic Trees/Animal Genes : TreeFamDDX41
Homologs : HomoloGeneDDX41
Homology/Alignments : Family Browser (UCSC)DDX41
Gene fusions - Rearrangements
Fusion : QuiverDDX41
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX41 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX41
dbVarDDX41
ClinVarDDX41
MonarchDDX41
1000_GenomesDDX41 
Exome Variant ServerDDX41
GNOMAD BrowserENSG00000183258
Varsome BrowserDDX41
ACMGDDX41 variants
VarityQ9UJV9
Genomic Variants (DGV)DDX41 [DGVbeta]
DECIPHERDDX41 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX41 
Mutations
ICGC Data PortalDDX41 
TCGA Data PortalDDX41 
Broad Tumor PortalDDX41
OASIS PortalDDX41 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX41  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDX41
Mutations and Diseases : HGMDDDX41
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDDX41
DgiDB (Drug Gene Interaction Database)DDX41
DoCM (Curated mutations)DDX41
CIViC (Clinical Interpretations of Variants in Cancer)DDX41
Cancer3DDDX41
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608170    616871   
Orphanet25413   
DisGeNETDDX41
MedgenDDX41
Genetic Testing Registry DDX41
NextProtQ9UJV9 [Medical]
GENETestsDDX41
Target ValidationDDX41
Huge Navigator DDX41 [HugePedia]
ClinGenDDX41
Clinical trials, drugs, therapy
MyCancerGenomeDDX41
Protein Interactions : CTDDDX41
Pharm GKB GenePA134908862
PharosQ9UJV9
Clinical trialDDX41
Miscellaneous
canSAR (ICR)DDX41
HarmonizomeDDX41
ARCHS4DDX41
DataMed IndexDDX41
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDDX41
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:30:14 CET 2022

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.