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DDX5 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 5)

Written2011-08Zhi-Ren Liu
Departments of Biology, Georgia State University, Atlanta, GA 30303, USA

(Note : for Links provided by Atlas : click)

Identity

Alias_namesHLR1
G17P1
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
Alias_symbol (synonym)p68
Other aliasDKFZp434E109
DKFZp686J01190
HUMP68
HGNC (Hugo) DDX5
LocusID (NCBI) 1655
Atlas_Id 40290
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 64498254 and ends at 64507038 bp from pter ( according to hg19-Feb_2009)  [Mapping DDX5.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CALM3 (19q13.32) / DDX5 (17q23.3)DDX5 (17q23.3) / ART1 (11p15.4)DDX5 (17q23.3) / DDX5 (17q23.3)
DDX5 (17q23.3) / DEPTOR (8q24.12)DDX5 (17q23.3) / ELOVL5 (6p12.1)DDX5 (17q23.3) / ETV4 (17q21.31)
DDX5 (17q23.3) / PFKP (10p15.2)DDX5 (17q23.3) / PIK3CA (3q26.32)DDX5 (17q23.3) / PRKCB (16p12.2)
DDX5 (17q23.3) / PRKDC (8q11.21)DDX5 (17q23.3) / RPL13 (16q24.3)DDX5 (17q23.3) / UTP4 (16q22.1)
ETV4 (17q21.31) / DDX5 (17q23.3)TMCC1 (3q22.1) / DDX5 (17q23.3)YWHAQ (2p25.1) / DDX5 (17q23.3)
Note DDX5/p68 RNA helicase is a member of DEAD box RNA helicases. As an example of a cellular RNA helicase, the ATPase and the RNA unwinding activities of p68 RNA helicase were documented with the protein that was purified from human 293 cells (Iggo and Lane, 1989; Ford et al.,1988; Hirling et al., 1989) and recombinant protein expressed in E. coli (Huang and Liu, 2002). The gene is expressed in all dividing cells of different vertebrates (Lane and Hoeffler, 1980; Stevenson et al., 1998). p68 RNA helicase is involved in multiple cellular processes, including gene transcription (Endoh et al., 1999; Rossow and Janknecht, 2003), pre-mRNA processing (Liu, 2002; Yang et al., 2006), pre-rRNA processing (Jalal et al., 2007), pre-miRNA processing (Fukuda et al., 2007), DNA methylation and de-methylation (Jost et al., 1999), and chromatin remodeling (Carter et al., 2010). A number of different post-translational modifications of p68 are reported, including phosphorylations, sumoylation, and ubiquitylation (Causevic et al., 2001; Yang et al., 2005; Jacobs et al., 2007).

DNA/RNA

Note DDX5/p68 RNA helicase is expressed in dividing cells of different vertebrates. Transcription of p68 RNA helicase gene generates a single mRNA precusor with 13 exons and 12 introns. Alternative splicing produces two mRNA transcripts, 2.3 kb and 4.4 kb (Rössler et al., 2000). The 2.3 kb mRNA transcript codes full length p68, while no translational product from the 4.4 kb mRNA transcript is detected in cellular and tissue extracts (Rössler et al., 2000).
 
  Diagram of pre-mRNA of p68 RNA helicase. The red bars are exons and the blue thin lines are introns.

Protein

 
  Domain structure of p68 RNA helicase. Functional sequence motifs are marked.
Description Size of p68; 614 amino acids, 69 kDa.
Expression Expressed in almost all tissue types. Its expression is increased in cancer cells.
Localisation Dominately localized in the cell nucleus. It is also found in the cytoplasm in various physiological conditions. p68 is a nucleocytoplasm shuttling protein (Wang et al., 2009).
Function Pre-mRNA splicing. The protein was demonstrated to associate with spliceosome by mass-spectroscopy and an RNA-protein crosslinking analyses (Hartmuth et al., 2002; Liu et al., 1997; Neubauer et al., 1998). p68 is functionally involved in assemble of the splicesome by mediating the U1 snRNP and the 5'ss interaction (Liu, 2002). p68 RNA helicase is also shown to regulate the splice site selection in the alternative splicing of several growth related genes, such as c-H-ras and tau (Kar et al., 2011; Guil et al., 2003).

Transcriptional regulation. The protein is shown to involve in transcriptional regulation by different mechanism of actions dependent on each individual regulated gene and biological processes (Stevenson et al., 1998; Endoh et al., 1999; Yang et al., 2005; Kahlina et al., 2004; Wei and Hu, 2001; Warner et al., 2004). p68 may regulate gene transcription by direct interaction with transcription factors or activators, such as p53, ERalpha (Endoh et al., 1999; Bates et al., 2005), or by mediating chromatin remodeling, such as modulating chromatin remodeling complex (Carter et al., 2010).

Epithelial-Mesenchymal-Transition (EMT). p68 becomes phosphorylated at Y593 upon growth factor stimulation by c-Abl. The tyrosine phosphorylation of p68 mediates growth factor stimulated Epithelial-Mesenchymal-Transition (EMT) (Yang et al., 2006).

Other functions. (1) p68 RNA helicase is shown to unwind the human let-7 microRNA precursor duplex. The protein is required for let-7-directed silencing of gene expression (Salzman et al., 2007). p68 is an indispensible part of Drosha complex. Its activity is required for primary miRNA and rRNA processing (Fukuda et al., 2007). (2) It is also demonstrated that the RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation (Caretti et al., 2006). (3) Phosphorylation of p68 at Thr residues mediates cell apoptosis (Yang et al., 2007).

Homology Yeast DBP2.

Mutations

Note Very few mutations of p68 gene were reported. A recent study shows that a S480A mutation in hepatic stellate cells is associated with hepatic fibrosis (Guo et al., 2010).

Implicated in

Note
  
Entity Colon cancer
Note p68 expression is significantly increased in colon cancer (Shin et al., 2007). Phosphorylation of p68 at Tyr correlation with colon cancer metastasis (Yang et al., 2006; Yang et al., 2005).
Prognosis Phosphorylation of p68 at tyrosine can be used as a diagnosis/prognosis marker for cancer.
  

Bibliography

The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.
Bates GJ, Nicol SM, Wilson BJ, Jacobs AM, Bourdon JC, Wardrop J, Gregory DJ, Lane DP, Perkins ND, Fuller-Pace FV.
EMBO J. 2005 Feb 9;24(3):543-53. Epub 2005 Jan 20.
PMID 15660129
 
The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.
Caretti G, Schiltz RL, Dilworth FJ, Di Padova M, Zhao P, Ogryzko V, Fuller-Pace FV, Hoffman EP, Tapscott SJ, Sartorelli V.
Dev Cell. 2006 Oct;11(4):547-60.
PMID 17011493
 
Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter.
Carter CL, Lin C, Liu CY, Yang L, Liu ZR.
Oncogene. 2010 Sep 30;29(39):5427-36. Epub 2010 Aug 2.
PMID 20676135
 
Overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumours.
Causevic M, Hislop RG, Kernohan NM, Carey FA, Kay RA, Steele RJ, Fuller-Pace FV.
Oncogene. 2001 Nov 22;20(53):7734-43.
PMID 11753651
 
Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.
Endoh H, Maruyama K, Masuhiro Y, Kobayashi Y, Goto M, Tai H, Yanagisawa J, Metzger D, Hashimoto S, Kato S.
Mol Cell Biol. 1999 Aug;19(8):5363-72.
PMID 10409727
 
Nuclear protein with sequence homology to translation initiation factor eIF-4A.
Ford MJ, Anton IA, Lane DP.
Nature. 1988 Apr 21;332(6166):736-8.
PMID 2451786
 
DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs.
Fukuda T, Yamagata K, Fujiyama S, Matsumoto T, Koshida I, Yoshimura K, Mihara M, Naitou M, Endoh H, Nakamura T, Akimoto C, Yamamoto Y, Katagiri T, Foulds C, Takezawa S, Kitagawa H, Takeyama K, O'Malley BW, Kato S.
Nat Cell Biol. 2007 May;9(5):604-11. Epub 2007 Apr 15.
PMID 17435748
 
Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation.
Guil S, Gattoni R, Carrascal M, Abian J, Stevenin J, Bach-Elias M.
Mol Cell Biol. 2003 Apr;23(8):2927-41.
PMID 12665590
 
A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.
Guo J, Hong F, Loke J, Yea S, Lim CL, Lee U, Mann DA, Walsh MJ, Sninsky JJ, Friedman SL.
J Biol Chem. 2010 Feb 19;285(8):5428-37. Epub 2009 Dec 17.
PMID 20022962
 
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.
Hartmuth K, Urlaub H, Vornlocher HP, Will CL, Gentzel M, Wilm M, Luhrmann R.
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16719-24. Epub 2002 Dec 11.
PMID 12477934
 
RNA helicase activity associated with the human p68 protein.
Hirling H, Scheffner M, Restle T, Stahl H.
Nature. 1989 Jun 15;339(6225):562-4.
PMID 2471939
 
The ATPase, RNA unwinding, and RNA binding activities of recombinant p68 RNA helicase.
Huang Y, Liu ZR.
J Biol Chem. 2002 Apr 12;277(15):12810-5. Epub 2002 Jan 31.
PMID 11823473
 
Nuclear protein p68 is an RNA-dependent ATPase.
Iggo RD, Lane DP.
EMBO J. 1989 Jun;8(6):1827-31.
PMID 2527746
 
SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.
Jacobs AM, Nicol SM, Hislop RG, Jaffray EG, Hay RT, Fuller-Pace FV.
Oncogene. 2007 Aug 30;26(40):5866-76. Epub 2007 Mar 19.
PMID Oncogene.
 
Redundant role of DEAD box proteins p68 (Ddx5) and p72/p82 (Ddx17) in ribosome biogenesis and cell proliferation.
Jalal C, Uhlmann-Schiffler H, Stahl H.
Nucleic Acids Res. 2007;35(11):3590-601. Epub 2007 May 7.
PMID 17485482
 
A chicken embryo protein related to the mammalian DEAD box protein p68 is tightly associated with the highly purified protein-RNA complex of 5-MeC-DNA glycosylase.
Jost JP, Schwarz S, Hess D, Angliker H, Fuller-Pace FV, Stahl H, Thiry S, Siegmann M.
Nucleic Acids Res. 1999 Aug 15;27(16):3245-52.
PMID 10454630
 
p68 DEAD box RNA helicase expression in keratinocytes. Regulation, nucleolar localization, and functional connection to proliferation and vascular endothelial growth factor gene expression.
Kahlina K, Goren I, Pfeilschifter J, Frank S.
J Biol Chem. 2004 Oct 22;279(43):44872-82. Epub 2004 Aug 10.
PMID 15304501
 
RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.
Kar A, Fushimi K, Zhou X, Ray P, Shi C, Chen X, Liu Z, Chen S, Wu JY.
Mol Cell Biol. 2011 May;31(9):1812-21. Epub 2011 Feb 22.
PMID 21343338
 
SV40 large T shares an antigenic determinant with a cellular protein of molecular weight 68,000.
Lane DP, Hoeffler WK.
Nature. 1980 Nov 13;288(5787):167-70.
PMID 6159551
 
Crosslinking of the U5 snRNP-specific 116-kDa protein to RNA hairpins that block step 2 of splicing.
Liu ZR, Laggerbauer B, Luhrmann R, Smith CW.
RNA. 1997 Nov;3(11):1207-19.
PMID 9409614
 
p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex.
Liu ZR.
Mol Cell Biol. 2002 Aug;22(15):5443-50.
PMID 12101238
 
Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.
Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M.
Nat Genet. 1998 Sep;20(1):46-50.
PMID 9731529
 
Structure and expression of the human p68 RNA helicase gene.
Rossler OG, Hloch P, Schutz N, Weitzenegger T, Stahl H.
Nucleic Acids Res. 2000 Feb 15;28(4):932-9.
PMID 10648785
 
Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.
Rossow KL, Janknecht R.
Oncogene. 2003 Jan 9;22(1):151-6.
PMID 12527917
 
P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression.
Salzman DW, Shubert-Coleman J, Furneaux H.
J Biol Chem. 2007 Nov 9;282(45):32773-9. Epub 2007 Aug 27.
PMID 17724023
 
Involvement of RNA helicases p68 and p72 in colon cancer.
Shin S, Rossow KL, Grande JP, Janknecht R.
Cancer Res. 2007 Aug 15;67(16):7572-8.
PMID 17699760
 
Expression of the 'dead box' RNA helicase p68 is developmentally and growth regulated and correlates with organ differentiation/maturation in the fetus.
Stevenson RJ, Hamilton SJ, MacCallum DE, Hall PA, Fuller-Pace FV.
J Pathol. 1998 Apr;184(4):351-9.
PMID 9664900
 
P68 RNA helicase is a nucleocytoplasmic shuttling protein.
Wang H, Gao X, Huang Y, Yang J, Liu ZR.
Cell Res. 2009 Dec;19(12):1388-400. Epub 2009 Sep 29.
PMID 19786986
 
Functional interaction between Smad, CREB binding protein, and p68 RNA helicase.
Warner DR, Bhattacherjee V, Yin X, Singh S, Mukhopadhyay P, Pisano MM, Greene RM.
Biochem Biophys Res Commun. 2004 Nov 5;324(1):70-6.
PMID 15464984
 
[The study of P68 RNA helicase on cell transformation].
Wei Y, Hu MH.
Yi Chuan Xue Bao. 2001 Nov;28(11):991-6.
PMID 11725646
 
A double tyrosine phosphorylation of P68 RNA helicase confers resistance to TRAIL-induced apoptosis.
Yang L, Lin C, Sun SY, Zhao S, Liu ZR.
Oncogene. 2007 Sep 6;26(41):6082-92. Epub 2007 Mar 26.
PMID 17384675
 

Citation

This paper should be referenced as such :
Liu, ZR
DDX5 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 5)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(1):44-47.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/DDX5ID40290ch17q23.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)DDX5   2746
Cards
AtlasDDX5ID40290ch17q23
Entrez_Gene (NCBI)DDX5  1655  DEAD-box helicase 5
AliasesG17P1; HLR1; HUMP68; p68
GeneCards (Weizmann)DDX5
Ensembl hg19 (Hinxton)ENSG00000108654 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108654 [Gene_View]  chr17:64498254-64507038 [Contig_View]  DDX5 [Vega]
ICGC DataPortalENSG00000108654
TCGA cBioPortalDDX5
AceView (NCBI)DDX5
Genatlas (Paris)DDX5
WikiGenes1655
SOURCE (Princeton)DDX5
Genetics Home Reference (NIH)DDX5
Genomic and cartography
GoldenPath hg38 (UCSC)DDX5  -     chr17:64498254-64507038 -  17q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX5  -     17q23.3   [Description]    (hg19-Feb_2009)
EnsemblDDX5 - 17q23.3 [CytoView hg19]  DDX5 - 17q23.3 [CytoView hg38]
Mapping of homologs : NCBIDDX5 [Mapview hg19]  DDX5 [Mapview hg38]
OMIM180630   
Gene and transcription
Genbank (Entrez)AB209919 AB451257 AB451382 AK055995 AK297192
RefSeq transcript (Entrez)NM_001320595 NM_001320596 NM_001320597 NM_004396
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDX5
Cluster EST : UnigeneHs.279806 [ NCBI ]
CGAP (NCI)Hs.279806
Alternative Splicing GalleryENSG00000108654
Gene ExpressionDDX5 [ NCBI-GEO ]   DDX5 [ EBI - ARRAY_EXPRESS ]   DDX5 [ SEEK ]   DDX5 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1655
GTEX Portal (Tissue expression)DDX5
Human Protein AtlasENSG00000108654-DDX5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17844   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17844  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17844
Splice isoforms : SwissVarP17844
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusP17844
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    P68_rpt    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)    P68HR (PF08061)   
Domain families : Pfam (NCBI)pfam00270    pfam00271    pfam08061   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  P68HR (SM01414)  
Conserved Domain (NCBI)DDX5
DMDM Disease mutations1655
Blocks (Seattle)DDX5
PDB (SRS)3FE2    4A4D   
PDB (PDBSum)3FE2    4A4D   
PDB (IMB)3FE2    4A4D   
PDB (RSDB)3FE2    4A4D   
Structural Biology KnowledgeBase3FE2    4A4D   
SCOP (Structural Classification of Proteins)3FE2    4A4D   
CATH (Classification of proteins structures)3FE2    4A4D   
SuperfamilyP17844
Human Protein Atlas [tissue]ENSG00000108654-DDX5 [tissue]
Peptide AtlasP17844
HPRD01615
IPIIPI00017617   IPI00947363   IPI00798375   IPI00984405   
Protein Interaction databases
DIP (DOE-UCLA)P17844
IntAct (EBI)P17844
FunCoupENSG00000108654
BioGRIDDDX5
STRING (EMBL)DDX5
ZODIACDDX5
Ontologies - Pathways
QuickGOP17844
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  nuclear-transcribed mRNA catabolic process  epithelial to mesenchymal transition  transcription coactivator activity  RNA binding  RNA helicase activity  RNA helicase activity  mRNA 3'-UTR binding  ATP-dependent RNA helicase activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  regulation of transcription from RNA polymerase II promoter  mRNA transcription  RNA secondary structure unwinding  membrane  cell growth  enzyme binding  estrogen receptor binding  BMP signaling pathway  intracellular estrogen receptor signaling pathway  androgen receptor signaling pathway  intracellular ribonucleoprotein complex  extracellular matrix  positive regulation of intracellular estrogen receptor signaling pathway  MH2 domain binding  pre-mRNA binding  ribonucleoprotein complex binding  positive regulation of DNA damage response, signal transduction by p53 class mediator  regulation of viral genome replication  myoblast differentiation  regulation of osteoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  SMAD binding  calcium-dependent protein binding  rhythmic process  androgen receptor binding  regulation of androgen receptor signaling pathway  pri-miRNA transcription from RNA polymerase II promoter  extracellular exosome  R-SMAD binding  primary miRNA binding  catalytic step 2 spliceosome  SMAD protein complex  intrinsic apoptotic signaling pathway by p53 class mediator  regulation of pri-miRNA transcription from RNA polymerase II promoter  positive regulation of production of miRNAs involved in gene silencing by miRNA  promoter-specific chromatin binding  regulation of skeletal muscle cell differentiation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  nuclear-transcribed mRNA catabolic process  epithelial to mesenchymal transition  transcription coactivator activity  RNA binding  RNA helicase activity  RNA helicase activity  mRNA 3'-UTR binding  ATP-dependent RNA helicase activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  regulation of transcription from RNA polymerase II promoter  mRNA transcription  RNA secondary structure unwinding  membrane  cell growth  enzyme binding  estrogen receptor binding  BMP signaling pathway  intracellular estrogen receptor signaling pathway  androgen receptor signaling pathway  intracellular ribonucleoprotein complex  extracellular matrix  positive regulation of intracellular estrogen receptor signaling pathway  MH2 domain binding  pre-mRNA binding  ribonucleoprotein complex binding  positive regulation of DNA damage response, signal transduction by p53 class mediator  regulation of viral genome replication  myoblast differentiation  regulation of osteoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  SMAD binding  calcium-dependent protein binding  rhythmic process  androgen receptor binding  regulation of androgen receptor signaling pathway  pri-miRNA transcription from RNA polymerase II promoter  extracellular exosome  R-SMAD binding  primary miRNA binding  catalytic step 2 spliceosome  SMAD protein complex  intrinsic apoptotic signaling pathway by p53 class mediator  regulation of pri-miRNA transcription from RNA polymerase II promoter  positive regulation of production of miRNAs involved in gene silencing by miRNA  promoter-specific chromatin binding  regulation of skeletal muscle cell differentiation  
Pathways : BIOCARTAAKAP95 role in mitosis and chromosome dynamics [Genes]   
Pathways : KEGGSpliceosome    Transcriptional misregulation in cancer    Proteoglycans in cancer   
REACTOMEP17844 [protein]
REACTOME PathwaysR-HSA-72163 [pathway]   
NDEx NetworkDDX5
Atlas of Cancer Signalling NetworkDDX5
Wikipedia pathwaysDDX5
Orthology - Evolution
OrthoDB1655
GeneTree (enSembl)ENSG00000108654
Phylogenetic Trees/Animal Genes : TreeFamDDX5
HOVERGENP17844
HOGENOMP17844
Homologs : HomoloGeneDDX5
Homology/Alignments : Family Browser (UCSC)DDX5
Gene fusions - Rearrangements
Fusion : MitelmanDDX5/ART1 [17q23.3/11p15.4]  
Fusion : MitelmanDDX5/DEPTOR [17q23.3/8q24.12]  [t(8;17)(q24;q23)]  
Fusion : MitelmanDDX5/ETV4 [17q23.3/17q21.31]  [t(17;17)(q21;q23)]  
Fusion : MitelmanDDX5/PFKP [17q23.3/10p15.2]  [t(10;17)(p15;q23)]  
Fusion : COSMICDDX5 [17q23.3]  -  ETV4 [17q21.31]  [fusion_1166]  [fusion_1167]  
Fusion: TCGADDX5 17q23.3 ART1 11p15.4 BRCA
Fusion: TCGADDX5 17q23.3 PFKP 10p15.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX5
dbVarDDX5
ClinVarDDX5
1000_GenomesDDX5 
Exome Variant ServerDDX5
ExAC (Exome Aggregation Consortium)ENSG00000108654
GNOMAD BrowserENSG00000108654
Genetic variants : HAPMAP1655
Genomic Variants (DGV)DDX5 [DGVbeta]
DECIPHERDDX5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX5 
Mutations
ICGC Data PortalDDX5 
TCGA Data PortalDDX5 
Broad Tumor PortalDDX5
OASIS PortalDDX5 [ Somatic mutations - Copy number]
Cancer Gene: CensusDDX5 
Somatic Mutations in Cancer : COSMICDDX5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDX5
intOGen PortalDDX5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX5
DgiDB (Drug Gene Interaction Database)DDX5
DoCM (Curated mutations)DDX5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX5 (select a term)
intoGenDDX5
NCG5 (London)DDX5
Cancer3DDDX5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180630   
Orphanet
MedgenDDX5
Genetic Testing Registry DDX5
NextProtP17844 [Medical]
TSGene1655
GENETestsDDX5
Target ValidationDDX5
Huge Navigator DDX5 [HugePedia]
snp3D : Map Gene to Disease1655
BioCentury BCIQDDX5
ClinGenDDX5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1655
Chemical/Pharm GKB GenePA27228
Clinical trialDDX5
Miscellaneous
canSAR (ICR)DDX5 (select the gene name)
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=DDX5
Probes
Litterature
PubMed198 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDX5
EVEXDDX5
GoPubMedDDX5
iHOPDDX5
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