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DDX50 (DExD-box helicase 50)

Identity

Alias (NCBI)GU2
GUB
RH-II/GuB
mcdrh
HGNC (Hugo) DDX50
HGNC Alias symbGU2
MGC3199
GUB
RH-II/GuB
HGNC Previous nameDEAD (Asp-Glu-Ala-Asp) box polypeptide 50
 DEAD-box helicase 50
LocusID (NCBI) 79009
Atlas_Id 62370
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 68901315 and ends at 68946847 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDX50 (10q22.1) / CDK13 (7p14.1)DDX50 (10q22.1) / HNRNPH3 (10q21.3)DDX50 (10q22.1) / SCRN1 (7p14.3)
DDX50 (10q22.1) / WASF1 (6q21)GNB1 (1p36.33) / DDX50 (10q22.1)KAT6B (10q22.2) / DDX50 (10q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)DDX50   17906
Cards
Entrez_Gene (NCBI)DDX50    DExD-box helicase 50
AliasesGU2; GUB; RH-II/GuB; mcdrh
GeneCards (Weizmann)DDX50
Ensembl hg19 (Hinxton)ENSG00000107625 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107625 [Gene_View]  ENSG00000107625 [Sequence]  chr10:68901315-68946847 [Contig_View]  DDX50 [Vega]
ICGC DataPortalENSG00000107625
TCGA cBioPortalDDX50
AceView (NCBI)DDX50
Genatlas (Paris)DDX50
SOURCE (Princeton)DDX50
Genetics Home Reference (NIH)DDX50
Genomic and cartography
GoldenPath hg38 (UCSC)DDX50  -     chr10:68901315-68946847 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDX50  -     10q22.1   [Description]    (hg19-Feb_2009)
GoldenPathDDX50 - 10q22.1 [CytoView hg19]  DDX50 - 10q22.1 [CytoView hg38]
ImmunoBaseENSG00000107625
Genome Data Viewer NCBIDDX50 [Mapview hg19]  
OMIM610373   
Gene and transcription
Genbank (Entrez)AB051075 AF334103 AK223297 AK293577 AK301431
RefSeq transcript (Entrez)NM_024045
Consensus coding sequences : CCDS (NCBI)DDX50
Gene ExpressionDDX50 [ NCBI-GEO ]   DDX50 [ EBI - ARRAY_EXPRESS ]   DDX50 [ SEEK ]   DDX50 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX50 [ Firebrowse - Broad ]
GenevisibleExpression of DDX50 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79009
GTEX Portal (Tissue expression)DDX50
Human Protein AtlasENSG00000107625-DDX50 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQ39   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQ39  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQ39
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BQ39
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    GUCT    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RBD_domain_sf    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    GUCT (PF08152)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam08152    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX50
PDB (RSDB)2.00E+29   
PDB Europe2.00E+29   
PDB (PDBSum)2.00E+29   
PDB (IMB)2.00E+29   
Structural Biology KnowledgeBase2.00E+29   
SCOP (Structural Classification of Proteins)2.00E+29   
CATH (Classification of proteins structures)2.00E+29   
SuperfamilyQ9BQ39
AlphaFold pdb e-kbQ9BQ39   
Human Protein Atlas [tissue]ENSG00000107625-DDX50 [tissue]
HPRD09910
Protein Interaction databases
DIP (DOE-UCLA)Q9BQ39
IntAct (EBI)Q9BQ39
BioGRIDDDX50
STRING (EMBL)DDX50
ZODIACDDX50
Ontologies - Pathways
QuickGOQ9BQ39
Ontology : AmiGORNA binding  RNA binding  RNA helicase activity  ATP binding  nucleolus  nucleolus  plasma membrane  membrane  hydrolase activity  
Ontology : EGO-EBIRNA binding  RNA binding  RNA helicase activity  ATP binding  nucleolus  nucleolus  plasma membrane  membrane  hydrolase activity  
Pathways : KEGGFolate biosynthesis    Starch and sucrose metabolism   
NDEx NetworkDDX50
Atlas of Cancer Signalling NetworkDDX50
Wikipedia pathwaysDDX50
Orthology - Evolution
OrthoDB79009
GeneTree (enSembl)ENSG00000107625
Phylogenetic Trees/Animal Genes : TreeFamDDX50
Homologs : HomoloGeneDDX50
Homology/Alignments : Family Browser (UCSC)DDX50
Gene fusions - Rearrangements
Fusion : QuiverDDX50
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX50 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX50
dbVarDDX50
ClinVarDDX50
MonarchDDX50
1000_GenomesDDX50 
Exome Variant ServerDDX50
GNOMAD BrowserENSG00000107625
Varsome BrowserDDX50
ACMGDDX50 variants
VarityQ9BQ39
Genomic Variants (DGV)DDX50 [DGVbeta]
DECIPHERDDX50 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDX50 
Mutations
ICGC Data PortalDDX50 
TCGA Data PortalDDX50 
Broad Tumor PortalDDX50
OASIS PortalDDX50 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDX50  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDX50
Mutations and Diseases : HGMDDDX50
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDDX50
DgiDB (Drug Gene Interaction Database)DDX50
DoCM (Curated mutations)DDX50
CIViC (Clinical Interpretations of Variants in Cancer)DDX50
Cancer3DDDX50
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610373   
Orphanet
DisGeNETDDX50
MedgenDDX50
Genetic Testing Registry DDX50
NextProtQ9BQ39 [Medical]
GENETestsDDX50
Target ValidationDDX50
Huge Navigator DDX50 [HugePedia]
ClinGenDDX50
Clinical trials, drugs, therapy
MyCancerGenomeDDX50
Protein Interactions : CTDDDX50
Pharm GKB GenePA134948525
PharosQ9BQ39
Clinical trialDDX50
Miscellaneous
canSAR (ICR)DDX50
HarmonizomeDDX50
DataMed IndexDDX50
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDDX50
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:47:34 CEST 2021
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