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DDX6 (DEAD-box helicase 6)

Identity

Alias_namesHLR2
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
Alias_symbol (synonym)RCK
Other aliasP54
HGNC (Hugo) DDX6
LocusID (NCBI) 1656
Atlas_Id 65
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118618473 and ends at 118661657 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DDX6 (11q23.3) / C14orf37 (14q23.1)DDX6 (11q23.3) / DDX6 (11q23.3)DDX6 (11q23.3) / FGD4 (12p11.21)
DDX6 (11q23.3) / FOXR1 (11q23.3)DDX6 (11q23.3) / IGH (14q32.33)DDX6 (11q23.3) / RAB7A (3q21.3)
DDX6 (11q23.3) / ROBO1 (3p12.3)DDX6 (11q23.3) / SRSF11 (1p31.1)DDX6 (11q23.3) / TSPAN18 (11p11.2)
IGH (14q32.33) / DDX6 (11q23.3)IGHG1 (14q32.33) / DDX6 (11q23.3)SHB (9p13.2) / DDX6 (11q23.3)
SORL1 (11q24.1) / DDX6 (11q23.3)DDX6 11q23.3 / FOXR1 11q23.3DDX6 11q23.3 / TSPAN18 11p11.2
SORL1 11q24.1 / DDX6 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  dup (11q) in myeloid malignancies
MLL amplification in leukemia


External links

Nomenclature
HGNC (Hugo)DDX6   2747
Cards
Entrez_Gene (NCBI)DDX6  1656  DEAD-box helicase 6
AliasesHLR2; P54; RCK
GeneCards (Weizmann)DDX6
Ensembl hg19 (Hinxton)ENSG00000110367 [Gene_View]  chr11:118618473-118661657 [Contig_View]  DDX6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000110367 [Gene_View]  chr11:118618473-118661657 [Contig_View]  DDX6 [Vega]
ICGC DataPortalENSG00000110367
TCGA cBioPortalDDX6
AceView (NCBI)DDX6
Genatlas (Paris)DDX6
WikiGenes1656
SOURCE (Princeton)DDX6
Genetics Home Reference (NIH)DDX6
Genomic and cartography
GoldenPath hg19 (UCSC)DDX6  -     chr11:118618473-118661657 -  11q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DDX6  -     11q23.3   [Description]    (hg38-Dec_2013)
EnsemblDDX6 - 11q23.3 [CytoView hg19]  DDX6 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIDDX6 [Mapview hg19]  DDX6 [Mapview hg38]
OMIM600326   
Gene and transcription
Genbank (Entrez)AI265778 AK021715 AK093657 AK313244 BC026228
RefSeq transcript (Entrez)NM_001257191 NM_004397
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)DDX6
Cluster EST : UnigeneHs.408461 [ NCBI ]
CGAP (NCI)Hs.408461
Alternative Splicing GalleryENSG00000110367
Gene ExpressionDDX6 [ NCBI-GEO ]   DDX6 [ EBI - ARRAY_EXPRESS ]   DDX6 [ SEEK ]   DDX6 [ MEM ]
Gene Expression Viewer (FireBrowse)DDX6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1656
GTEX Portal (Tissue expression)DDX6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26196   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26196  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26196
Splice isoforms : SwissVarP26196
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusP26196
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)DDX6
DMDM Disease mutations1656
Blocks (Seattle)DDX6
PDB (SRS)1VEC    2WAX    2WAY    4CRW    4CT4    4CT5    5ANR   
PDB (PDBSum)1VEC    2WAX    2WAY    4CRW    4CT4    4CT5    5ANR   
PDB (IMB)1VEC    2WAX    2WAY    4CRW    4CT4    4CT5    5ANR   
PDB (RSDB)1VEC    2WAX    2WAY    4CRW    4CT4    4CT5    5ANR   
Structural Biology KnowledgeBase1VEC    2WAX    2WAY    4CRW    4CT4    4CT5    5ANR   
SCOP (Structural Classification of Proteins)1VEC    2WAX    2WAY    4CRW    4CT4    4CT5    5ANR   
CATH (Classification of proteins structures)1VEC    2WAX    2WAY    4CRW    4CT4    4CT5    5ANR   
SuperfamilyP26196
Human Protein AtlasENSG00000110367
Peptide AtlasP26196
HPRD02638
IPIIPI00030320   IPI01015091   
Protein Interaction databases
DIP (DOE-UCLA)P26196
IntAct (EBI)P26196
FunCoupENSG00000110367
BioGRIDDDX6
STRING (EMBL)DDX6
ZODIACDDX6
Ontologies - Pathways
QuickGOP26196
Ontology : AmiGOcytoplasmic mRNA processing body  cytoplasmic mRNA processing body  RNA helicase activity  ATP-dependent RNA helicase activity  helicase activity  protein binding  ATP binding  cytoplasm  cytosol  regulation of translation  cytoplasmic stress granule  RNA secondary structure unwinding  membrane  RISC complex  viral RNA genome packaging  stem cell population maintenance  protein domain specific binding  cytoplasmic mRNA processing body assembly  intracellular membrane-bounded organelle  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  poly(A) RNA binding  negative regulation of neuron differentiation  
Ontology : EGO-EBIcytoplasmic mRNA processing body  cytoplasmic mRNA processing body  RNA helicase activity  ATP-dependent RNA helicase activity  helicase activity  protein binding  ATP binding  cytoplasm  cytosol  regulation of translation  cytoplasmic stress granule  RNA secondary structure unwinding  membrane  RISC complex  viral RNA genome packaging  stem cell population maintenance  protein domain specific binding  cytoplasmic mRNA processing body assembly  intracellular membrane-bounded organelle  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  poly(A) RNA binding  negative regulation of neuron differentiation  
Pathways : KEGGRNA degradation   
NDEx NetworkDDX6
Atlas of Cancer Signalling NetworkDDX6
Wikipedia pathwaysDDX6
Orthology - Evolution
OrthoDB1656
GeneTree (enSembl)ENSG00000110367
Phylogenetic Trees/Animal Genes : TreeFamDDX6
HOVERGENP26196
HOGENOMP26196
Homologs : HomoloGeneDDX6
Homology/Alignments : Family Browser (UCSC)DDX6
Gene fusions - Rearrangements
Fusion : MitelmanDDX6/FOXR1 [11q23.3/11q23.3]  
Fusion : MitelmanDDX6/TSPAN18 [11q23.3/11p11.2]  [t(11;11)(p11;q23)]  
Fusion : MitelmanIGH/DDX6 [14q32.33/11q23.3]  [t(11;14)(q23;q32)]  
Fusion : MitelmanSORL1/DDX6 [11q24.1/11q23.3]  [t(11;11)(q23;q24)]  
Fusion: TCGADDX6 11q23.3 FOXR1 11q23.3 BRCA
Fusion: TCGADDX6 11q23.3 TSPAN18 11p11.2 LGG
Fusion: TCGASORL1 11q24.1 DDX6 11q23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDX6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDX6
dbVarDDX6
ClinVarDDX6
1000_GenomesDDX6 
Exome Variant ServerDDX6
ExAC (Exome Aggregation Consortium)DDX6 (select the gene name)
Genetic variants : HAPMAP1656
Genomic Variants (DGV)DDX6 [DGVbeta]
DECIPHER (Syndromes)11:118618473-118661657  ENSG00000110367
CONAN: Copy Number AnalysisDDX6 
Mutations
ICGC Data PortalDDX6 
TCGA Data PortalDDX6 
Broad Tumor PortalDDX6
OASIS PortalDDX6 [ Somatic mutations - Copy number]
Cancer Gene: CensusDDX6 
Somatic Mutations in Cancer : COSMICDDX6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDDX6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DDX6
DgiDB (Drug Gene Interaction Database)DDX6
DoCM (Curated mutations)DDX6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDX6 (select a term)
intoGenDDX6
Cancer3DDDX6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600326   
Orphanet
MedgenDDX6
Genetic Testing Registry DDX6
NextProtP26196 [Medical]
TSGene1656
GENETestsDDX6
Huge Navigator DDX6 [HugePedia]
snp3D : Map Gene to Disease1656
BioCentury BCIQDDX6
ClinGenDDX6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1656
Chemical/Pharm GKB GenePA27229
Clinical trialDDX6
Miscellaneous
canSAR (ICR)DDX6 (select the gene name)
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDX6
EVEXDDX6
GoPubMedDDX6
iHOPDDX6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:03:01 CET 2017

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