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DEDD2 (death effector domain containing 2)

Identity

Alias_symbol (synonym)FLAME-3
Other aliasFLAME3
HGNC (Hugo) DEDD2
LocusID (NCBI) 162989
Atlas_Id 62378
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 42198593 and ends at 42220152 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DEDD2 (19q13.2) / EPB41L2 (6q23.1)ZNF526 (19q13.2) / DEDD2 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DEDD2   24450
Cards
Entrez_Gene (NCBI)DEDD2  162989  death effector domain containing 2
AliasesFLAME-3; FLAME3
GeneCards (Weizmann)DEDD2
Ensembl hg19 (Hinxton)ENSG00000160570 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160570 [Gene_View]  chr19:42198593-42220152 [Contig_View]  DEDD2 [Vega]
ICGC DataPortalENSG00000160570
TCGA cBioPortalDEDD2
AceView (NCBI)DEDD2
Genatlas (Paris)DEDD2
WikiGenes162989
SOURCE (Princeton)DEDD2
Genetics Home Reference (NIH)DEDD2
Genomic and cartography
GoldenPath hg38 (UCSC)DEDD2  -     chr19:42198593-42220152 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DEDD2  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblDEDD2 - 19q13.2 [CytoView hg19]  DEDD2 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIDEDD2 [Mapview hg19]  DEDD2 [Mapview hg38]
OMIM617078   
Gene and transcription
Genbank (Entrez)AA635978 AF443591 AF457575 AK075328 AK130203
RefSeq transcript (Entrez)NM_001270614 NM_001270615 NM_133328
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DEDD2
Cluster EST : UnigeneHs.741580 [ NCBI ]
CGAP (NCI)Hs.741580
Alternative Splicing GalleryENSG00000160570
Gene ExpressionDEDD2 [ NCBI-GEO ]   DEDD2 [ EBI - ARRAY_EXPRESS ]   DEDD2 [ SEEK ]   DEDD2 [ MEM ]
Gene Expression Viewer (FireBrowse)DEDD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)162989
GTEX Portal (Tissue expression)DEDD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXF8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WXF8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WXF8
Splice isoforms : SwissVarQ8WXF8
PhosPhoSitePlusQ8WXF8
Domaine pattern : Prosite (Expaxy)DED (PS50168)   
Domains : Interpro (EBI)DEATH-like_dom    DED_dom   
Domain families : Pfam (Sanger)DED (PF01335)   
Domain families : Pfam (NCBI)pfam01335   
Domain families : Smart (EMBL)DED (SM00031)  
Conserved Domain (NCBI)DEDD2
DMDM Disease mutations162989
Blocks (Seattle)DEDD2
SuperfamilyQ8WXF8
Human Protein AtlasENSG00000160570
Peptide AtlasQ8WXF8
HPRD10868
IPIIPI00103531   IPI00410190   
Protein Interaction databases
DIP (DOE-UCLA)Q8WXF8
IntAct (EBI)Q8WXF8
FunCoupENSG00000160570
BioGRIDDEDD2
STRING (EMBL)DEDD2
ZODIACDEDD2
Ontologies - Pathways
QuickGOQ8WXF8
Ontology : AmiGODNA binding  protein binding  nucleolus  transcription, DNA-templated  RNA processing  extrinsic apoptotic signaling pathway via death domain receptors  rRNA catabolic process  cellular homeostasis  receptor signaling complex scaffold activity  apoptotic nuclear changes  intracellular signal transduction  negative regulation of transcription, DNA-templated  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIDNA binding  protein binding  nucleolus  transcription, DNA-templated  RNA processing  extrinsic apoptotic signaling pathway via death domain receptors  rRNA catabolic process  cellular homeostasis  receptor signaling complex scaffold activity  apoptotic nuclear changes  intracellular signal transduction  negative regulation of transcription, DNA-templated  positive regulation of extrinsic apoptotic signaling pathway  
NDEx NetworkDEDD2
Atlas of Cancer Signalling NetworkDEDD2
Wikipedia pathwaysDEDD2
Orthology - Evolution
OrthoDB162989
GeneTree (enSembl)ENSG00000160570
Phylogenetic Trees/Animal Genes : TreeFamDEDD2
HOVERGENQ8WXF8
HOGENOMQ8WXF8
Homologs : HomoloGeneDEDD2
Homology/Alignments : Family Browser (UCSC)DEDD2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDEDD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DEDD2
dbVarDEDD2
ClinVarDEDD2
1000_GenomesDEDD2 
Exome Variant ServerDEDD2
ExAC (Exome Aggregation Consortium)DEDD2 (select the gene name)
Genetic variants : HAPMAP162989
Genomic Variants (DGV)DEDD2 [DGVbeta]
DECIPHERDEDD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDEDD2 
Mutations
ICGC Data PortalDEDD2 
TCGA Data PortalDEDD2 
Broad Tumor PortalDEDD2
OASIS PortalDEDD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDEDD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDEDD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DEDD2
DgiDB (Drug Gene Interaction Database)DEDD2
DoCM (Curated mutations)DEDD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DEDD2 (select a term)
intoGenDEDD2
Cancer3DDEDD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617078   
Orphanet
MedgenDEDD2
Genetic Testing Registry DEDD2
NextProtQ8WXF8 [Medical]
TSGene162989
GENETestsDEDD2
Target ValidationDEDD2
Huge Navigator DEDD2 [HugePedia]
snp3D : Map Gene to Disease162989
BioCentury BCIQDEDD2
ClinGenDEDD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD162989
Chemical/Pharm GKB GenePA134912744
Clinical trialDEDD2
Miscellaneous
canSAR (ICR)DEDD2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDEDD2
EVEXDEDD2
GoPubMedDEDD2
iHOPDEDD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:45:32 CEST 2017

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