Identity
HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
DEF1,DEFA2,HNP-1,HP-1,HP1,MRS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1667
MIM: 125220
HGNC: 2761
Ensembl: ENSG00000206047
Variants:
dbSNP: 1667
ClinVar: 1667
TCGA: ENSG00000206047
COSMIC: DEFA1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000206047 | ENST00000382679 | P59665 |
| ENSG00000206047 | ENST00000382692 | P59665 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36729968 | 2023 | Alpha Defensin-1 Biomarker Outperforms Culture in Diagnosing Breast Implant-Related Infection: Results from a Multicenter Prospective Study. | 1 |
| 36729968 | 2023 | Alpha Defensin-1 Biomarker Outperforms Culture in Diagnosing Breast Implant-Related Infection: Results from a Multicenter Prospective Study. | 1 |
| 34487793 | 2022 | Inhibition of SARS-CoV-2 Infection by Human Defensin HNP1 and Retrocyclin RC-101. | 16 |
| 34487793 | 2022 | Inhibition of SARS-CoV-2 Infection by Human Defensin HNP1 and Retrocyclin RC-101. | 16 |
| 34746027 | 2021 | Elevated Levels of Neutrophil Activated Proteins, Alpha-Defensins (DEFA1), Calprotectin (S100A8/A9) and Myeloperoxidase (MPO) Are Associated With Disease Severity in COVID-19 Patients. | 23 |
| 34746027 | 2021 | Elevated Levels of Neutrophil Activated Proteins, Alpha-Defensins (DEFA1), Calprotectin (S100A8/A9) and Myeloperoxidase (MPO) Are Associated With Disease Severity in COVID-19 Patients. | 23 |
| 32302327 | 2020 | Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis. | 9 |
| 33294439 | 2020 | Alpha-Defensin versus Leukocyte Esterase in Periprosthetic Joint Infection: An Updated Meta-Analysis. | 5 |
| 32302327 | 2020 | Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis. | 9 |
| 33294439 | 2020 | Alpha-Defensin versus Leukocyte Esterase in Periprosthetic Joint Infection: An Updated Meta-Analysis. | 5 |
| 29635426 | 2018 | Human alpha-defensin-1 protects cells from intoxication with Clostridium perfringens iota toxin. | 6 |
| 29738776 | 2018 | Neutralization of Pseudomonas auruginosa Exotoxin A by human neutrophil peptide 1. | 1 |
| 29950924 | 2018 | Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients. | 3 |
| 29635426 | 2018 | Human alpha-defensin-1 protects cells from intoxication with Clostridium perfringens iota toxin. | 6 |
| 29738776 | 2018 | Neutralization of Pseudomonas auruginosa Exotoxin A by human neutrophil peptide 1. | 1 |
Citation
Dessen P
DEFA1 (defensin alpha 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43620/defa1
