Identity
HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
BD-3,DEFB-3,DEFB103,DEFB3,HBD3,HBP-3,HBP3
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 414325
HGNC: 15967
Ensembl: ENSG00000176797
Variants:
dbSNP: 414325
ClinVar: 414325
TCGA: ENSG00000176797
COSMIC: DEFB103A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000176797 | ENST00000314357 | P81534 |
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 29487594 | 2018 | Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS. | 18 |
| 29758092 | 2018 | Langerhans cells express human β-defensin 3: relevance for immunity during skin ageing. | 10 |
| 29487594 | 2018 | Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS. | 18 |
| 29758092 | 2018 | Langerhans cells express human β-defensin 3: relevance for immunity during skin ageing. | 10 |
| 28102569 | 2017 | Human β-defensin 3 increases the TLR9-dependent response to bacterial DNA. | 17 |
| 28102569 | 2017 | Human β-defensin 3 increases the TLR9-dependent response to bacterial DNA. | 17 |
| 25196417 | 2015 | Potential roles of placental human beta-defensin-3 and apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G in prevention of intrauterine transmission of hepatitis B virus. | 9 |
| 26224324 | 2015 | Association between DEFB103 gene copy number variation and ankylosing spondylitis: a case-control study. | 2 |
| 25196417 | 2015 | Potential roles of placental human beta-defensin-3 and apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G in prevention of intrauterine transmission of hepatitis B virus. | 9 |
| 26224324 | 2015 | Association between DEFB103 gene copy number variation and ankylosing spondylitis: a case-control study. | 2 |
| 22951718 | 2013 | Human beta-defensin 3 induces maturation of human langerhans cell-like dendritic cells: an antimicrobial peptide that functions as an endogenous adjuvant. | 31 |
| 23194186 | 2013 | Variation in human β-defensin genes: new insights from a multi-population study. | 8 |
| 23511030 | 2013 | Human β-defensin 3 peptide is increased and redistributed in Crohn's ileitis. | 19 |
| 23659571 | 2013 | Human β-defensin-3 structure motifs that are important in CXCR4 antagonism. | 10 |
| 23776172 | 2013 | β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation. | 46 |
Citation
Dessen P
DEFB103A (defensin beta 103A)
Atlas Genet Cytogenet Oncol Haematol. 2011-04-01
Online version: http://atlasgeneticsoncology.org/gene/52193/defb103a
