DEFB103A (defensin beta 103A)

2011-04-01  

Identity

HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
BD-3,DEFB-3,DEFB103,DEFB3,HBD3,HBP-3,HBP3

Other Information

Locus ID:

NCBI: 414325
HGNC: 15967
Ensembl: ENSG00000176797

Variants:

dbSNP: 414325
ClinVar: 414325
TCGA: ENSG00000176797
COSMIC: DEFB103A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176797ENST00000314357P81534

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DefensinsREACTOMER-HSA-1461973
Beta defensinsREACTOMER-HSA-1461957
Antimicrobial peptidesREACTOMER-HSA-6803157

References

Pubmed IDYearTitleCitations
212809822011Human beta-defensin-1, -2, and -3 exhibit opposite effects on oral squamous cell carcinoma cell proliferation.17
215200742012Human β-defensins differently affect proliferation, differentiation, and mineralization of osteoblast-like MG63 cells.16
206189592010Differential and coordinated expression of defensins and cytokines by gingival epithelial cells and dendritic cells in response to oral bacteria.15
210716082011Human β-defensin 3 promotes NF-κB-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck.15
229517182013Human beta-defensin 3 induces maturation of human langerhans cell-like dendritic cells: an antimicrobial peptide that functions as an endogenous adjuvant.10
209709652010PPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes.9
214421292011High-Glucose Environment Inhibits p38MAPK Signaling and Reduces Human β-Defensin-3 Expression [corrected] in Keratinocytes.9
211221322010Tissue-specific human beta-defensins (HBD)1, HBD2, and HBD3 secretion from human extra-placental membranes stimulated with Escherichia coli.7
231941862013Variation in human β-defensin genes: new insights from a multi-population study.7
236595712013Human β-defensin-3 structure motifs that are important in CXCR4 antagonism.7

Citation

Dessen P

DEFB103A (defensin beta 103A)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52193/defb103a