DEFB4A (defensin beta 4A)

2010-05-01  

Identity

HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
BD-2,DEFB-2,DEFB102,DEFB2,DEFB4,HBD-2,SAP1

Other Information

Locus ID:

NCBI: 1673
MIM: 602215
HGNC: 2767
Ensembl: ENSG00000171711

Variants:

dbSNP: 1673
ClinVar: 1673
TCGA: ENSG00000171711
COSMIC: DEFB4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171711ENST00000302247O15263

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DefensinsREACTOMER-HSA-1461973
Beta defensinsREACTOMER-HSA-1461957
Antimicrobial peptidesREACTOMER-HSA-6803157
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

References

Pubmed IDYearTitleCitations
380706282024β-defensin 2 protects against Escherichia coli-induced acute urinary tract infection by downregulating β-catenin.0
381896742024Molecular Dynamics Simulations on Spike Protein Mutants Binding with Human β Defensin Type 2.0
382469442024Salivary Th17 cytokine, human β-defensin 1-3, and salivary scavenger and agglutinin levels in Crohn's disease.0
389653122024Identification of human host factors required for beta-defensin-2 expression in intestinal epithelial cells upon a bacterial challenge.0
380706282024β-defensin 2 protects against Escherichia coli-induced acute urinary tract infection by downregulating β-catenin.0
381896742024Molecular Dynamics Simulations on Spike Protein Mutants Binding with Human β Defensin Type 2.0
382469442024Salivary Th17 cytokine, human β-defensin 1-3, and salivary scavenger and agglutinin levels in Crohn's disease.0
389653122024Identification of human host factors required for beta-defensin-2 expression in intestinal epithelial cells upon a bacterial challenge.0
372537032023Therapeutic modalities of human β defensin-2 with prospective significance in diabetic wound treatment.1
372537032023Therapeutic modalities of human β defensin-2 with prospective significance in diabetic wound treatment.1
363108772022Antimicrobial peptide human β-defensin-2 improves in vitro cellular viability and reduces pro-inflammatory effects induced by enteroinvasive Escherichia coli in Caco-2 cells by inhibiting invasion and virulence factors' expression.3
365426902022Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling.5
363108772022Antimicrobial peptide human β-defensin-2 improves in vitro cellular viability and reduces pro-inflammatory effects induced by enteroinvasive Escherichia coli in Caco-2 cells by inhibiting invasion and virulence factors' expression.3
365426902022Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling.5
337171822021Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model.10

Citation

Dessen P

DEFB4A (defensin beta 4A)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51501/defb4a