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DENND10 (DENN domain containing 10)

Identity

Alias (NCBI)FAM45A
HGNC (Hugo) DENND10
HGNC Previous namefamily with sequence similarity 45, member A
LocusID (NCBI) 404636
Atlas_Id 63198
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 119104113 and ends at 119137984 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)DENND10   31793
Cards
Entrez_Gene (NCBI)DENND10    DENN domain containing 10
AliasesFAM45A
GeneCards (Weizmann)DENND10
Ensembl hg19 (Hinxton)ENSG00000119979 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119979 [Gene_View]  ENSG00000119979 [Sequence]  chr10:119104113-119137984 [Contig_View]  DENND10 [Vega]
ICGC DataPortalENSG00000119979
TCGA cBioPortalDENND10
AceView (NCBI)DENND10
Genatlas (Paris)DENND10
SOURCE (Princeton)DENND10
Genetics Home Reference (NIH)DENND10
Genomic and cartography
GoldenPath hg38 (UCSC)DENND10  -     chr10:119104113-119137984 +  10q26.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND10  -     10q26.11   [Description]    (hg19-Feb_2009)
GoldenPathDENND10 - 10q26.11 [CytoView hg19]  DENND10 - 10q26.11 [CytoView hg38]
ImmunoBaseENSG00000119979
Genome Data Viewer NCBIDENND10 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AF168713 AK000031 AK025354 AK027029 AK293136
RefSeq transcript (Entrez)NM_001303111 NM_001303112 NM_001303113 NM_207009
Consensus coding sequences : CCDS (NCBI)DENND10
Gene ExpressionDENND10 [ NCBI-GEO ]   DENND10 [ EBI - ARRAY_EXPRESS ]   DENND10 [ SEEK ]   DENND10 [ MEM ]
Gene Expression Viewer (FireBrowse)DENND10 [ Firebrowse - Broad ]
GenevisibleExpression of DENND10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)404636
GTEX Portal (Tissue expression)DENND10
Human Protein AtlasENSG00000119979-DENND10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TCE6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TCE6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TCE6
PhosPhoSitePlusQ8TCE6
Domaine pattern : Prosite (Expaxy)DENN (PS50211)   
Domains : Interpro (EBI)FAM45    Tripartite_DENN   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DENND10
SuperfamilyQ8TCE6
AlphaFold pdb e-kbQ8TCE6   
Human Protein Atlas [tissue]ENSG00000119979-DENND10 [tissue]
HPRD13310
Protein Interaction databases
DIP (DOE-UCLA)Q8TCE6
IntAct (EBI)Q8TCE6
BioGRIDDENND10
STRING (EMBL)DENND10
ZODIACDENND10
Ontologies - Pathways
QuickGOQ8TCE6
Ontology : AmiGOguanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  late endosome  late endosome  protein transport  protein transport  small GTPase binding  small GTPase binding  endosome transport via multivesicular body sorting pathway  regulation of catalytic activity  regulation of early endosome to late endosome transport  regulation of early endosome to late endosome transport  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  late endosome  late endosome  protein transport  protein transport  small GTPase binding  small GTPase binding  endosome transport via multivesicular body sorting pathway  regulation of catalytic activity  regulation of early endosome to late endosome transport  regulation of early endosome to late endosome transport  
NDEx NetworkDENND10
Atlas of Cancer Signalling NetworkDENND10
Wikipedia pathwaysDENND10
Orthology - Evolution
OrthoDB404636
GeneTree (enSembl)ENSG00000119979
Phylogenetic Trees/Animal Genes : TreeFamDENND10
Homologs : HomoloGeneDENND10
Homology/Alignments : Family Browser (UCSC)DENND10
Gene fusions - Rearrangements
Fusion : QuiverDENND10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND10
dbVarDENND10
ClinVarDENND10
MonarchDENND10
1000_GenomesDENND10 
Exome Variant ServerDENND10
GNOMAD BrowserENSG00000119979
Varsome BrowserDENND10
ACMGDENND10 variants
VarityQ8TCE6
Genomic Variants (DGV)DENND10 [DGVbeta]
DECIPHERDENND10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND10 
Mutations
ICGC Data PortalDENND10 
TCGA Data PortalDENND10 
Broad Tumor PortalDENND10
OASIS PortalDENND10 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDENND10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDENND10
DgiDB (Drug Gene Interaction Database)DENND10
DoCM (Curated mutations)DENND10
CIViC (Clinical Interpretations of Variants in Cancer)DENND10
Cancer3DDENND10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETDENND10
MedgenDENND10
Genetic Testing Registry DENND10
NextProtQ8TCE6 [Medical]
GENETestsDENND10
Target ValidationDENND10
Huge Navigator DENND10 [HugePedia]
ClinGenDENND10
Clinical trials, drugs, therapy
MyCancerGenomeDENND10
Protein Interactions : CTDDENND10
Pharm GKB GenePA134935316
PharosQ8TCE6
Clinical trialDENND10
Miscellaneous
canSAR (ICR)DENND10
HarmonizomeDENND10
DataMed IndexDENND10
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDENND10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:47:46 CEST 2021

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