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DENND1A (DENN domain containing 1A)

Identity

Alias_namesKIAA1608
KIAA1608
DENN/MADD domain containing 1A
Alias_symbol (synonym)FLJ21129
FAM31A
Other alias
HGNC (Hugo) DENND1A
LocusID (NCBI) 57706
Atlas_Id 53186
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 123401591 and ends at 123930138 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCNY (10p11.21) / DENND1A (9q33.3)DENND1A (9q33.3) / ANXA4 (2p13.3)DENND1A (9q33.3) / CADPS2 (7q31.32)
DENND1A (9q33.3) / DENND1A (9q33.3)DENND1A (9q33.3) / LRRC69 (8q21.3)DENND1A (9q33.3) / PRRX2 (9q34.11)
HNRNPM (19p13.2) / DENND1A (9q33.3)LRSAM1 (9q33.3) / DENND1A (9q33.3)PTGES2 (9q34.11) / DENND1A (9q33.3)
SNX30 (9q32) / DENND1A (9q33.3)STRBP (9q33.3) / DENND1A (9q33.3)UHRF1BP1L (12q23.1) / DENND1A (9q33.3)
CCNY 10p11.21 / DENND1A 9q33.3DENND1A 9q33.3 / CADPS2 7q31.32DENND1A 9q33.3 / LRRC69 8q21.3
DENND1A 9q33.3 / PRRX2 9q34.11LRSAM1 9q33.3 / DENND1A 9q33.3PTGES2 9q34.11 / DENND1A 9q33.3
SNX30 9q32 / DENND1A 9q33.3STRBP 9q33.3 / DENND1A 9q33.3UHRF1BP1L 12q23.1 / DENND1A 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;9)(p13;q33) DENND1A/ZCCHC7


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 12 ]
  t(2;9)(p13;q33) DENND1A/ANXA4
t(5;9)(q22;q33) CAMK4/DENND1A
t(7;9)(q31;q33) DENND1A/CADPS2
t(8;9)(q21;q33) DENND1A/LRRC69
t(9;9)(q32;q33) SNX30/DENND1A
LRSAM1/DENND1A (9q33)
STRBP/DENND1A (9q33)
STRBP/DENND1A (9q33)
t(9;9)(q33;q34) DENND1A/PRRX2
t(9;9)(q33;q34) PTGES2/DENND1A
t(9;10)(q33;p11) CCNY/DENND1A
t(9;12)(q33;q23) UHRF1BP1L/DENND1A


External links

Nomenclature
HGNC (Hugo)DENND1A   29324
Cards
Entrez_Gene (NCBI)DENND1A  57706  DENN domain containing 1A
AliasesFAM31A; KIAA1608
GeneCards (Weizmann)DENND1A
Ensembl hg19 (Hinxton)ENSG00000119522 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119522 [Gene_View]  ENSG00000119522 [Sequence]  chr9:123401591-123930138 [Contig_View]  DENND1A [Vega]
ICGC DataPortalENSG00000119522
TCGA cBioPortalDENND1A
AceView (NCBI)DENND1A
Genatlas (Paris)DENND1A
WikiGenes57706
SOURCE (Princeton)DENND1A
Genetics Home Reference (NIH)DENND1A
Genomic and cartography
GoldenPath hg38 (UCSC)DENND1A  -     chr9:123401591-123930138 -  9q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND1A  -     9q33.3   [Description]    (hg19-Feb_2009)
EnsemblDENND1A - 9q33.3 [CytoView hg19]  DENND1A - 9q33.3 [CytoView hg38]
Mapping of homologs : NCBIDENND1A [Mapview hg19]  DENND1A [Mapview hg38]
OMIM613633   
Gene and transcription
Genbank (Entrez)AB046828 AK024782 AK074151 AK225104 AK295710
RefSeq transcript (Entrez)NM_001352964 NM_001352965 NM_001352966 NM_001352967 NM_001352968 NM_020946 NM_024820
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DENND1A
Cluster EST : UnigeneHs.744995 [ NCBI ]
CGAP (NCI)Hs.744995
Alternative Splicing GalleryENSG00000119522
Gene ExpressionDENND1A [ NCBI-GEO ]   DENND1A [ EBI - ARRAY_EXPRESS ]   DENND1A [ SEEK ]   DENND1A [ MEM ]
Gene Expression Viewer (FireBrowse)DENND1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57706
GTEX Portal (Tissue expression)DENND1A
Human Protein AtlasENSG00000119522-DENND1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEH3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEH3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEH3
Splice isoforms : SwissVarQ8TEH3
PhosPhoSitePlusQ8TEH3
Domaine pattern : Prosite (Expaxy)DENN (PS50211)   
Domains : Interpro (EBI)cDENN_dom    dDENN_dom    Tripartite_DENN    uDENN_dom   
Domain families : Pfam (Sanger)dDENN (PF03455)    DENN (PF02141)    uDENN (PF03456)   
Domain families : Pfam (NCBI)pfam03455    pfam02141    pfam03456   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  uDENN (SM00800)  
Conserved Domain (NCBI)DENND1A
DMDM Disease mutations57706
Blocks (Seattle)DENND1A
SuperfamilyQ8TEH3
Human Protein Atlas [tissue]ENSG00000119522-DENND1A [tissue]
Peptide AtlasQ8TEH3
HPRD17221
IPIIPI00170641   IPI00645340   IPI00872202   IPI00449176   IPI00900334   IPI00922655   IPI00983955   IPI00165927   
Protein Interaction databases
DIP (DOE-UCLA)Q8TEH3
IntAct (EBI)Q8TEH3
FunCoupENSG00000119522
BioGRIDDENND1A
STRING (EMBL)DENND1A
ZODIACDENND1A
Ontologies - Pathways
QuickGOQ8TEH3
Ontology : AmiGOnucleoplasm  cytosol  cytosol  cytosol  endocytosis  endocytosis  protein transport  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  SH3 domain binding  Rab GTPase binding  cell junction  clathrin-coated vesicle  clathrin-coated vesicle  dendrite  clathrin-coated vesicle membrane  phosphatidylinositol-3-phosphate binding  endocytic recycling  endocytic recycling  regulation of Rab protein signal transduction  presynaptic membrane  neuronal cell body  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  positive regulation of GTPase activity  synaptic vesicle endocytosis  phosphatidylinositol phosphate binding  phosphatidylinositol phosphate binding  
Ontology : EGO-EBInucleoplasm  cytosol  cytosol  cytosol  endocytosis  endocytosis  protein transport  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  SH3 domain binding  Rab GTPase binding  cell junction  clathrin-coated vesicle  clathrin-coated vesicle  dendrite  clathrin-coated vesicle membrane  phosphatidylinositol-3-phosphate binding  endocytic recycling  endocytic recycling  regulation of Rab protein signal transduction  presynaptic membrane  neuronal cell body  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  positive regulation of GTPase activity  synaptic vesicle endocytosis  phosphatidylinositol phosphate binding  phosphatidylinositol phosphate binding  
NDEx NetworkDENND1A
Atlas of Cancer Signalling NetworkDENND1A
Wikipedia pathwaysDENND1A
Orthology - Evolution
OrthoDB57706
GeneTree (enSembl)ENSG00000119522
Phylogenetic Trees/Animal Genes : TreeFamDENND1A
HOGENOMQ8TEH3
Homologs : HomoloGeneDENND1A
Homology/Alignments : Family Browser (UCSC)DENND1A
Gene fusions - Rearrangements
Fusion : MitelmanCCNY/DENND1A [10p11.21/9q33.3]  [t(9;10)(q33;p11)]  
Fusion : MitelmanDENND1A/ANXA4 [9q33.3/2p13.3]  [t(2;9)(p13;q33)]  
Fusion : MitelmanDENND1A/CADPS2 [9q33.3/7q31.32]  [t(7;9)(q31;q33)]  
Fusion : MitelmanDENND1A/LRRC69 [9q33.3/8q21.3]  [t(8;9)(q21;q33)]  
Fusion : MitelmanDENND1A/PRRX2 [9q33.3/9q34.11]  [t(9;9)(q33;q34)]  
Fusion : MitelmanLRSAM1/DENND1A [9q33.3/9q33.3]  [t(9;9)(q33;q33)]  
Fusion : MitelmanPTGES2/DENND1A [9q34.11/9q33.3]  [t(9;9)(q33;q34)]  
Fusion : MitelmanSNX30/DENND1A [9q32/9q33.3]  [t(9;9)(q32;q33)]  
Fusion : MitelmanSTRBP/DENND1A [9q33.3/9q33.3]  [t(9;9)(q33;q33)]  
Fusion : MitelmanUHRF1BP1L/DENND1A [12q23.1/9q33.3]  [t(9;12)(q33;q23)]  
Fusion PortalCCNY 10p11.21 DENND1A 9q33.3 BRCA
Fusion PortalDENND1A 9q33.3 CADPS2 7q31.32 BRCA
Fusion PortalDENND1A 9q33.3 LRRC69 8q21.3 BRCA
Fusion PortalDENND1A 9q33.3 PRRX2 9q34.11 HNSC
Fusion PortalLRSAM1 9q33.3 DENND1A 9q33.3 BRCA
Fusion PortalPTGES2 9q34.11 DENND1A 9q33.3 BRCA
Fusion PortalSNX30 9q32 DENND1A 9q33.3 BRCA
Fusion PortalSTRBP 9q33.3 DENND1A 9q33.3 BRCA
Fusion PortalUHRF1BP1L 12q23.1 DENND1A 9q33.3 BRCA
Fusion : QuiverDENND1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND1A
dbVarDENND1A
ClinVarDENND1A
1000_GenomesDENND1A 
Exome Variant ServerDENND1A
ExAC (Exome Aggregation Consortium)ENSG00000119522
GNOMAD BrowserENSG00000119522
Varsome BrowserDENND1A
Genetic variants : HAPMAP57706
Genomic Variants (DGV)DENND1A [DGVbeta]
DECIPHERDENND1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND1A 
Mutations
ICGC Data PortalDENND1A 
TCGA Data PortalDENND1A 
Broad Tumor PortalDENND1A
OASIS PortalDENND1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDENND1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDENND1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND1A
DgiDB (Drug Gene Interaction Database)DENND1A
DoCM (Curated mutations)DENND1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND1A (select a term)
intoGenDENND1A
Cancer3DDENND1A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613633   
Orphanet
DisGeNETDENND1A
MedgenDENND1A
Genetic Testing Registry DENND1A
NextProtQ8TEH3 [Medical]
TSGene57706
GENETestsDENND1A
Target ValidationDENND1A
Huge Navigator DENND1A [HugePedia]
snp3D : Map Gene to Disease57706
BioCentury BCIQDENND1A
ClinGenDENND1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57706
Chemical/Pharm GKB GenePA134876117
Clinical trialDENND1A
Miscellaneous
canSAR (ICR)DENND1A (select the gene name)
DataMed IndexDENND1A
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND1A
EVEXDENND1A
GoPubMedDENND1A
iHOPDENND1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:09:24 CET 2019

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