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DENND1B (DENN domain containing 1B)

Identity

Alias_namesFAM31B
C1orf218
family with sequence similarity 31, member B
chromosome 1 open reading frame 218
DENN/MADD domain containing 1B
Alias_symbol (synonym)MGC27044
FLJ20054
Other aliasC1ORF18
HGNC (Hugo) DENND1B
LocusID (NCBI) 163486
Atlas_Id 62427
Location 1q31.3  [Link to chromosome band 1q31]
Location_base_pair Starts at 197504749 and ends at 197775493 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DENND1B (1q31.3) / CCSER1 (4q22.1)DENND1B (1q31.3) / RCOR3 (1q32.2)DENND1B (1q31.3) / RGL1 (1q25.3)
DENND1B (1q31.3) / RRP15 (1q41)DENND1B (1q31.3) / ZCCHC7 (9p13.2)DENND1B FAM190A
DENND1B RRP15DENND1B RCOR3DENND1B RGL1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DENND1B   28404
Cards
Entrez_Gene (NCBI)DENND1B  163486  DENN domain containing 1B
AliasesC1ORF18; C1orf218; FAM31B
GeneCards (Weizmann)DENND1B
Ensembl hg19 (Hinxton)ENSG00000213047 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213047 [Gene_View]  chr1:197504749-197775493 [Contig_View]  DENND1B [Vega]
ICGC DataPortalENSG00000213047
TCGA cBioPortalDENND1B
AceView (NCBI)DENND1B
Genatlas (Paris)DENND1B
WikiGenes163486
SOURCE (Princeton)DENND1B
Genetics Home Reference (NIH)DENND1B
Genomic and cartography
GoldenPath hg38 (UCSC)DENND1B  -     chr1:197504749-197775493 -  1q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND1B  -     1q31.3   [Description]    (hg19-Feb_2009)
EnsemblDENND1B - 1q31.3 [CytoView hg19]  DENND1B - 1q31.3 [CytoView hg38]
Mapping of homologs : NCBIDENND1B [Mapview hg19]  DENND1B [Mapview hg38]
OMIM613292   
Gene and transcription
Genbank (Entrez)AI692985 AK000061 AK024832 AK091207 AK093982
RefSeq transcript (Entrez)NM_001142795 NM_001195215 NM_001195216 NM_001300858 NM_019049 NM_144977
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DENND1B
Cluster EST : UnigeneHs.745032 [ NCBI ]
CGAP (NCI)Hs.745032
Alternative Splicing GalleryENSG00000213047
Gene ExpressionDENND1B [ NCBI-GEO ]   DENND1B [ EBI - ARRAY_EXPRESS ]   DENND1B [ SEEK ]   DENND1B [ MEM ]
Gene Expression Viewer (FireBrowse)DENND1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)163486
GTEX Portal (Tissue expression)DENND1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P3S1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P3S1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P3S1
Splice isoforms : SwissVarQ6P3S1
PhosPhoSitePlusQ6P3S1
Domaine pattern : Prosite (Expaxy)DDENN (PS50947)    DENN (PS50211)    UDENN (PS50946)   
Domains : Interpro (EBI)dDENN_dom    DENN_dom    uDENN_dom   
Domain families : Pfam (Sanger)dDENN (PF03455)    DENN (PF02141)    uDENN (PF03456)   
Domain families : Pfam (NCBI)pfam03455    pfam02141    pfam03456   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  uDENN (SM00800)  
Conserved Domain (NCBI)DENND1B
DMDM Disease mutations163486
Blocks (Seattle)DENND1B
PDB (SRS)3TW8   
PDB (PDBSum)3TW8   
PDB (IMB)3TW8   
PDB (RSDB)3TW8   
Structural Biology KnowledgeBase3TW8   
SCOP (Structural Classification of Proteins)3TW8   
CATH (Classification of proteins structures)3TW8   
SuperfamilyQ6P3S1
Human Protein AtlasENSG00000213047
Peptide AtlasQ6P3S1
HPRD13303
IPIIPI00440495   IPI00640432   IPI00856032   IPI00900353   IPI01010473   IPI00059795   IPI00941427   IPI00916031   
Protein Interaction databases
DIP (DOE-UCLA)Q6P3S1
IntAct (EBI)Q6P3S1
FunCoupENSG00000213047
BioGRIDDENND1B
STRING (EMBL)DENND1B
ZODIACDENND1B
Ontologies - Pathways
QuickGOQ6P3S1
Ontology : AmiGOcytosol  cytosol  protein transport  nuclear speck  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  Rab GTPase binding  clathrin-coated vesicle  endocytic recycling  T-helper 2 cell cytokine production  positive regulation of GTPase activity  regulation of immune response  T cell receptor signaling pathway  membrane organization  
Ontology : EGO-EBIcytosol  cytosol  protein transport  nuclear speck  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  Rab GTPase binding  clathrin-coated vesicle  endocytic recycling  T-helper 2 cell cytokine production  positive regulation of GTPase activity  regulation of immune response  T cell receptor signaling pathway  membrane organization  
NDEx NetworkDENND1B
Atlas of Cancer Signalling NetworkDENND1B
Wikipedia pathwaysDENND1B
Orthology - Evolution
OrthoDB163486
GeneTree (enSembl)ENSG00000213047
Phylogenetic Trees/Animal Genes : TreeFamDENND1B
HOVERGENQ6P3S1
HOGENOMQ6P3S1
Homologs : HomoloGeneDENND1B
Homology/Alignments : Family Browser (UCSC)DENND1B
Gene fusions - Rearrangements
Fusion: TCGADENND1B FAM190A
Fusion: TCGADENND1B RRP15
Fusion: TCGADENND1B RCOR3
Fusion: TCGADENND1B RGL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND1B
dbVarDENND1B
ClinVarDENND1B
1000_GenomesDENND1B 
Exome Variant ServerDENND1B
ExAC (Exome Aggregation Consortium)DENND1B (select the gene name)
Genetic variants : HAPMAP163486
Genomic Variants (DGV)DENND1B [DGVbeta]
DECIPHERDENND1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND1B 
Mutations
ICGC Data PortalDENND1B 
TCGA Data PortalDENND1B 
Broad Tumor PortalDENND1B
OASIS PortalDENND1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDENND1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDENND1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND1B
DgiDB (Drug Gene Interaction Database)DENND1B
DoCM (Curated mutations)DENND1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND1B (select a term)
intoGenDENND1B
Cancer3DDENND1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613292   
Orphanet
MedgenDENND1B
Genetic Testing Registry DENND1B
NextProtQ6P3S1 [Medical]
TSGene163486
GENETestsDENND1B
Target ValidationDENND1B
Huge Navigator DENND1B [HugePedia]
snp3D : Map Gene to Disease163486
BioCentury BCIQDENND1B
ClinGenDENND1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD163486
Chemical/Pharm GKB GenePA134951951
Clinical trialDENND1B
Miscellaneous
canSAR (ICR)DENND1B (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND1B
EVEXDENND1B
GoPubMedDENND1B
iHOPDENND1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:06:08 CEST 2017

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