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DENND2A (DENN domain containing 2A)

Identity

Alias_namesKIAA1277
KIAA1277
DENN/MADD domain containing 2A
Alias_symbol (synonym)FAM31D
Other alias
HGNC (Hugo) DENND2A
LocusID (NCBI) 27147
Atlas_Id 62429
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 140518419 and ends at 140640776 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARSB (5q14.1) / DENND2A (7q34)HIPK2 (7q34) / DENND2A (7q34)MKRN1 (7q34) / DENND2A (7q34)
RNF122 (8p12) / DENND2A (7q34)MKRN1 DENND2AHIPK2 DENND2A

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DENND2A   22212
Cards
Entrez_Gene (NCBI)DENND2A  27147  DENN domain containing 2A
AliasesFAM31D; KIAA1277
GeneCards (Weizmann)DENND2A
Ensembl hg19 (Hinxton)ENSG00000146966 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146966 [Gene_View]  chr7:140518419-140640776 [Contig_View]  DENND2A [Vega]
ICGC DataPortalENSG00000146966
TCGA cBioPortalDENND2A
AceView (NCBI)DENND2A
Genatlas (Paris)DENND2A
WikiGenes27147
SOURCE (Princeton)DENND2A
Genetics Home Reference (NIH)DENND2A
Genomic and cartography
GoldenPath hg38 (UCSC)DENND2A  -     chr7:140518419-140640776 -  7q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND2A  -     7q34   [Description]    (hg19-Feb_2009)
EnsemblDENND2A - 7q34 [CytoView hg19]  DENND2A - 7q34 [CytoView hg38]
Mapping of homologs : NCBIDENND2A [Mapview hg19]  DENND2A [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB033103 AI040169 AK290056 AK297959 BC049193
RefSeq transcript (Entrez)NM_001318052 NM_001318053 NM_015689
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DENND2A
Cluster EST : UnigeneHs.6385 [ NCBI ]
CGAP (NCI)Hs.6385
Alternative Splicing GalleryENSG00000146966
Gene ExpressionDENND2A [ NCBI-GEO ]   DENND2A [ EBI - ARRAY_EXPRESS ]   DENND2A [ SEEK ]   DENND2A [ MEM ]
Gene Expression Viewer (FireBrowse)DENND2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27147
GTEX Portal (Tissue expression)DENND2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULE3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULE3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULE3
Splice isoforms : SwissVarQ9ULE3
PhosPhoSitePlusQ9ULE3
Domaine pattern : Prosite (Expaxy)DDENN (PS50947)    DENN (PS50211)    UDENN (PS50946)   
Domains : Interpro (EBI)dDENN_dom    DENN_dom    uDENN_dom   
Domain families : Pfam (Sanger)dDENN (PF03455)    DENN (PF02141)    uDENN (PF03456)   
Domain families : Pfam (NCBI)pfam03455    pfam02141    pfam03456   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  uDENN (SM00800)  
Conserved Domain (NCBI)DENND2A
DMDM Disease mutations27147
Blocks (Seattle)DENND2A
SuperfamilyQ9ULE3
Human Protein AtlasENSG00000146966
Peptide AtlasQ9ULE3
HPRD17210
IPIIPI00472075   IPI00761166   IPI00910069   IPI00945161   IPI00946387   IPI00945606   IPI00946133   IPI00946786   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULE3
IntAct (EBI)Q9ULE3
FunCoupENSG00000146966
BioGRIDDENND2A
STRING (EMBL)DENND2A
ZODIACDENND2A
Ontologies - Pathways
QuickGOQ9ULE3
Ontology : AmiGOcytosol  protein transport  actin cytoskeleton  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  retrograde transport, endosome to Golgi  positive regulation of GTPase activity  membrane organization  
Ontology : EGO-EBIcytosol  protein transport  actin cytoskeleton  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  retrograde transport, endosome to Golgi  positive regulation of GTPase activity  membrane organization  
NDEx NetworkDENND2A
Atlas of Cancer Signalling NetworkDENND2A
Wikipedia pathwaysDENND2A
Orthology - Evolution
OrthoDB27147
GeneTree (enSembl)ENSG00000146966
Phylogenetic Trees/Animal Genes : TreeFamDENND2A
HOVERGENQ9ULE3
HOGENOMQ9ULE3
Homologs : HomoloGeneDENND2A
Homology/Alignments : Family Browser (UCSC)DENND2A
Gene fusions - Rearrangements
Fusion: TCGAMKRN1 DENND2A
Fusion: TCGAHIPK2 DENND2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND2A
dbVarDENND2A
ClinVarDENND2A
1000_GenomesDENND2A 
Exome Variant ServerDENND2A
ExAC (Exome Aggregation Consortium)DENND2A (select the gene name)
Genetic variants : HAPMAP27147
Genomic Variants (DGV)DENND2A [DGVbeta]
DECIPHERDENND2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND2A 
Mutations
ICGC Data PortalDENND2A 
TCGA Data PortalDENND2A 
Broad Tumor PortalDENND2A
OASIS PortalDENND2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDENND2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDENND2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND2A
DgiDB (Drug Gene Interaction Database)DENND2A
DoCM (Curated mutations)DENND2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND2A (select a term)
intoGenDENND2A
Cancer3DDENND2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenDENND2A
Genetic Testing Registry DENND2A
NextProtQ9ULE3 [Medical]
TSGene27147
GENETestsDENND2A
Target ValidationDENND2A
Huge Navigator DENND2A [HugePedia]
snp3D : Map Gene to Disease27147
BioCentury BCIQDENND2A
ClinGenDENND2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27147
Chemical/Pharm GKB GenePA134931054
Clinical trialDENND2A
Miscellaneous
canSAR (ICR)DENND2A (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND2A
EVEXDENND2A
GoPubMedDENND2A
iHOPDENND2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:45:43 CEST 2017

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