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DENND2D (DENN domain containing 2D)

Identity

Alias (NCBI)-
HGNC (Hugo) DENND2D
HGNC Alias symbFLJ22457
RP5-1180E21.2
HGNC Previous nameDENN/MADD domain containing 2D
LocusID (NCBI) 79961
Atlas_Id 46828
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 111185969 and ends at 111200646 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHCYL1 (1p13.3) / DENND2D (1p13.3)DENND2D (1p13.3) / DENND2D (1p13.3)AHCYL1 1p13.3 / DENND2D 1p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  AHCYL1/DENND2D (1p13)

External links

Nomenclature
HGNC (Hugo)DENND2D   26192
Cards
Entrez_Gene (NCBI)DENND2D    DENN domain containing 2D
Aliases
GeneCards (Weizmann)DENND2D
Ensembl hg19 (Hinxton)ENSG00000162777 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162777 [Gene_View]  ENSG00000162777 [Sequence]  chr1:111185969-111200646 [Contig_View]  DENND2D [Vega]
ICGC DataPortalENSG00000162777
TCGA cBioPortalDENND2D
AceView (NCBI)DENND2D
Genatlas (Paris)DENND2D
SOURCE (Princeton)DENND2D
Genetics Home Reference (NIH)DENND2D
Genomic and cartography
GoldenPath hg38 (UCSC)DENND2D  -     chr1:111185969-111200646 -  1p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND2D  -     1p13.3   [Description]    (hg19-Feb_2009)
GoldenPathDENND2D - 1p13.3 [CytoView hg19]  DENND2D - 1p13.3 [CytoView hg38]
ImmunoBaseENSG00000162777
genome Data Viewer NCBIDENND2D [Mapview hg19]  
OMIM615111   
Gene and transcription
Genbank (Entrez)AK026110 AK057181 AK301583 AL713773 BC004557
RefSeq transcript (Entrez)NM_001271833 NM_024901
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DENND2D
Alternative Splicing GalleryENSG00000162777
Gene ExpressionDENND2D [ NCBI-GEO ]   DENND2D [ EBI - ARRAY_EXPRESS ]   DENND2D [ SEEK ]   DENND2D [ MEM ]
Gene Expression Viewer (FireBrowse)DENND2D [ Firebrowse - Broad ]
GenevisibleExpression of DENND2D in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79961
GTEX Portal (Tissue expression)DENND2D
Human Protein AtlasENSG00000162777-DENND2D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H6A0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H6A0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H6A0
Splice isoforms : SwissVarQ9H6A0
PhosPhoSitePlusQ9H6A0
Domaine pattern : Prosite (Expaxy)DENN (PS50211)   
Domains : Interpro (EBI)cDENN_dom    dDENN_dom    Tripartite_DENN    uDENN_dom   
Domain families : Pfam (Sanger)dDENN (PF03455)    DENN (PF02141)    uDENN (PF03456)   
Domain families : Pfam (NCBI)pfam03455    pfam02141    pfam03456   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  uDENN (SM00800)  
Conserved Domain (NCBI)DENND2D
Blocks (Seattle)DENND2D
SuperfamilyQ9H6A0
Human Protein Atlas [tissue]ENSG00000162777-DENND2D [tissue]
Peptide AtlasQ9H6A0
HPRD08655
IPIIPI00641666   IPI00165037   
Protein Interaction databases
DIP (DOE-UCLA)Q9H6A0
IntAct (EBI)Q9H6A0
BioGRIDDENND2D
STRING (EMBL)DENND2D
ZODIACDENND2D
Ontologies - Pathways
QuickGOQ9H6A0
Ontology : AmiGOprotein binding  nucleoplasm  nucleoplasm  cytosol  cytosol  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  
Ontology : EGO-EBIprotein binding  nucleoplasm  nucleoplasm  cytosol  cytosol  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  
NDEx NetworkDENND2D
Atlas of Cancer Signalling NetworkDENND2D
Wikipedia pathwaysDENND2D
Orthology - Evolution
OrthoDB79961
GeneTree (enSembl)ENSG00000162777
Phylogenetic Trees/Animal Genes : TreeFamDENND2D
HOGENOMQ9H6A0
Homologs : HomoloGeneDENND2D
Homology/Alignments : Family Browser (UCSC)DENND2D
Gene fusions - Rearrangements
Fusion : MitelmanAHCYL1/DENND2D [1p13.3/1p13.3]  
Fusion PortalAHCYL1 1p13.3 DENND2D 1p13.3 BRCA
Fusion : QuiverDENND2D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND2D [hg38]
dbVarDENND2D
ClinVarDENND2D
MonarchDENND2D
1000_GenomesDENND2D 
Exome Variant ServerDENND2D
GNOMAD BrowserENSG00000162777
Varsome BrowserDENND2D
Genomic Variants (DGV)DENND2D [DGVbeta]
DECIPHERDENND2D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND2D 
Mutations
ICGC Data PortalDENND2D 
TCGA Data PortalDENND2D 
Broad Tumor PortalDENND2D
OASIS PortalDENND2D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDENND2D  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDENND2D
Mutations and Diseases : HGMDDENND2D
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND2D
DgiDB (Drug Gene Interaction Database)DENND2D
DoCM (Curated mutations)DENND2D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND2D (select a term)
intoGenDENND2D
Cancer3DDENND2D(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615111   
Orphanet
DisGeNETDENND2D
MedgenDENND2D
Genetic Testing Registry DENND2D
NextProtQ9H6A0 [Medical]
GENETestsDENND2D
Target ValidationDENND2D
Huge Navigator DENND2D [HugePedia]
ClinGenDENND2D
Clinical trials, drugs, therapy
MyCancerGenomeDENND2D
Protein Interactions : CTD
Pharm GKB GenePA142671986
PharosQ9H6A0
Clinical trialDENND2D
Miscellaneous
canSAR (ICR)DENND2D (select the gene name)
HarmonizomeDENND2D
DataMed IndexDENND2D
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDENND2D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:12:44 CET 2021
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