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DENND3 (DENN domain containing 3)

Identity

Alias_namesDENN/MADD domain containing 3
Alias_symbol (synonym)KIAA0870
Other alias-
HGNC (Hugo) DENND3
LocusID (NCBI) 22898
Atlas_Id 62431
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 141128621 and ends at 141195801 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DENND3 (8q24.3) / DENND3 (8q24.3)DENND3 (8q24.3) / MZB1 (5q31.2)PCDH12 (5q31.3) / DENND3 (8q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DENND3   29134
Cards
Entrez_Gene (NCBI)DENND3  22898  DENN domain containing 3
Aliases
GeneCards (Weizmann)DENND3
Ensembl hg19 (Hinxton)ENSG00000105339 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105339 [Gene_View]  chr8:141128621-141195801 [Contig_View]  DENND3 [Vega]
ICGC DataPortalENSG00000105339
TCGA cBioPortalDENND3
AceView (NCBI)DENND3
Genatlas (Paris)DENND3
WikiGenes22898
SOURCE (Princeton)DENND3
Genetics Home Reference (NIH)DENND3
Genomic and cartography
GoldenPath hg38 (UCSC)DENND3  -     chr8:141128621-141195801 +  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND3  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblDENND3 - 8q24.3 [CytoView hg19]  DENND3 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIDENND3 [Mapview hg19]  DENND3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB020677 AK057136 AK058001 AK091556 AK123283
RefSeq transcript (Entrez)NM_014957
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DENND3
Cluster EST : UnigeneHs.18166 [ NCBI ]
CGAP (NCI)Hs.18166
Alternative Splicing GalleryENSG00000105339
Gene ExpressionDENND3 [ NCBI-GEO ]   DENND3 [ EBI - ARRAY_EXPRESS ]   DENND3 [ SEEK ]   DENND3 [ MEM ]
Gene Expression Viewer (FireBrowse)DENND3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22898
GTEX Portal (Tissue expression)DENND3
Protein : pattern, domain, 3D structure
UniProt/SwissProtA2RUS2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA2RUS2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA2RUS2
Splice isoforms : SwissVarA2RUS2
PhosPhoSitePlusA2RUS2
Domaine pattern : Prosite (Expaxy)DDENN (PS50947)    DENN (PS50211)    UDENN (PS50946)    WD_REPEATS_1 (PS00678)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)dDENN_dom    DENN_dom    uDENN_dom    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)DENN (PF02141)   
Domain families : Pfam (NCBI)pfam02141   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  WD40 (SM00320)  
Conserved Domain (NCBI)DENND3
DMDM Disease mutations22898
Blocks (Seattle)DENND3
SuperfamilyA2RUS2
Human Protein AtlasENSG00000105339
Peptide AtlasA2RUS2
HPRD11114
IPIIPI00856077   IPI00442078   IPI00855922   IPI00448616   IPI00981127   IPI00973778   IPI00975716   IPI00979160   IPI00974426   IPI00974227   IPI00981524   
Protein Interaction databases
DIP (DOE-UCLA)A2RUS2
IntAct (EBI)A2RUS2
FunCoupENSG00000105339
BioGRIDDENND3
STRING (EMBL)DENND3
ZODIACDENND3
Ontologies - Pathways
QuickGOA2RUS2
Ontology : AmiGOcytosol  endosome to lysosome transport  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  positive regulation of GTPase activity  cellular protein catabolic process  membrane organization  
Ontology : EGO-EBIcytosol  endosome to lysosome transport  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  positive regulation of GTPase activity  cellular protein catabolic process  membrane organization  
NDEx NetworkDENND3
Atlas of Cancer Signalling NetworkDENND3
Wikipedia pathwaysDENND3
Orthology - Evolution
OrthoDB22898
GeneTree (enSembl)ENSG00000105339
Phylogenetic Trees/Animal Genes : TreeFamDENND3
HOVERGENA2RUS2
HOGENOMA2RUS2
Homologs : HomoloGeneDENND3
Homology/Alignments : Family Browser (UCSC)DENND3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND3
dbVarDENND3
ClinVarDENND3
1000_GenomesDENND3 
Exome Variant ServerDENND3
ExAC (Exome Aggregation Consortium)DENND3 (select the gene name)
Genetic variants : HAPMAP22898
Genomic Variants (DGV)DENND3 [DGVbeta]
DECIPHERDENND3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND3 
Mutations
ICGC Data PortalDENND3 
TCGA Data PortalDENND3 
Broad Tumor PortalDENND3
OASIS PortalDENND3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDENND3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDENND3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND3
DgiDB (Drug Gene Interaction Database)DENND3
DoCM (Curated mutations)DENND3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND3 (select a term)
intoGenDENND3
Cancer3DDENND3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenDENND3
Genetic Testing Registry DENND3
NextProtA2RUS2 [Medical]
TSGene22898
GENETestsDENND3
Target ValidationDENND3
Huge Navigator DENND3 [HugePedia]
snp3D : Map Gene to Disease22898
BioCentury BCIQDENND3
ClinGenDENND3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22898
Chemical/Pharm GKB GenePA142671987
Clinical trialDENND3
Miscellaneous
canSAR (ICR)DENND3 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND3
EVEXDENND3
GoPubMedDENND3
iHOPDENND3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:45:43 CEST 2017

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