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DENND4A (DENN domain containing 4A)

Identity

Alias_namesMYCPBP
c-myc promoter binding protein
DENN/MADD domain containing 4A
Alias_symbol (synonym)IRLB
Other alias
HGNC (Hugo) DENND4A
LocusID (NCBI) 10260
Atlas_Id 40993
Location 15q22.31  [Link to chromosome band 15q22]
Location_base_pair Starts at 65659123 and ends at 65792293 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DENND4A (15q22.31) / DENND4A (15q22.31)DENND4A (15q22.31) / RAB11A (15q22.31)DENND4A (15q22.31) / SYCP2 (20q13.33)
RAB11A (15q22.31) / DENND4A (15q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DENND4A   24321
Cards
Entrez_Gene (NCBI)DENND4A  10260  DENN domain containing 4A
AliasesIRLB; MYCPBP
GeneCards (Weizmann)DENND4A
Ensembl hg19 (Hinxton)ENSG00000174485 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174485 [Gene_View]  chr15:65659123-65792293 [Contig_View]  DENND4A [Vega]
ICGC DataPortalENSG00000174485
TCGA cBioPortalDENND4A
AceView (NCBI)DENND4A
Genatlas (Paris)DENND4A
WikiGenes10260
SOURCE (Princeton)DENND4A
Genetics Home Reference (NIH)DENND4A
Genomic and cartography
GoldenPath hg38 (UCSC)DENND4A  -     chr15:65659123-65792293 -  15q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND4A  -     15q22.31   [Description]    (hg19-Feb_2009)
EnsemblDENND4A - 15q22.31 [CytoView hg19]  DENND4A - 15q22.31 [CytoView hg38]
Mapping of homologs : NCBIDENND4A [Mapview hg19]  DENND4A [Mapview hg38]
OMIM600382   
Gene and transcription
Genbank (Entrez)AF534403 AK091268 AK091368 AK290292 AK299570
RefSeq transcript (Entrez)NM_001144823 NM_001320835 NM_005848
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DENND4A
Cluster EST : UnigeneHs.654567 [ NCBI ]
CGAP (NCI)Hs.654567
Alternative Splicing GalleryENSG00000174485
Gene ExpressionDENND4A [ NCBI-GEO ]   DENND4A [ EBI - ARRAY_EXPRESS ]   DENND4A [ SEEK ]   DENND4A [ MEM ]
Gene Expression Viewer (FireBrowse)DENND4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10260
GTEX Portal (Tissue expression)DENND4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z401   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z401  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z401
Splice isoforms : SwissVarQ7Z401
PhosPhoSitePlusQ7Z401
Domaine pattern : Prosite (Expaxy)DDENN (PS50947)    DENN (PS50211)    MABP (PS51498)    PPR (PS51375)    UDENN (PS50946)   
Domains : Interpro (EBI)dDENN_dom    DENN_dom    MABP    Pentatricopeptide_repeat    uDENN_dom   
Domain families : Pfam (Sanger)dDENN (PF03455)    DENN (PF02141)    uDENN (PF03456)   
Domain families : Pfam (NCBI)pfam03455    pfam02141    pfam03456   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  uDENN (SM00800)  
Conserved Domain (NCBI)DENND4A
DMDM Disease mutations10260
Blocks (Seattle)DENND4A
SuperfamilyQ7Z401
Human Protein AtlasENSG00000174485
Peptide AtlasQ7Z401
HPRD02662
IPIIPI00396063   IPI01009374   IPI00921122   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z401
IntAct (EBI)Q7Z401
FunCoupENSG00000174485
BioGRIDDENND4A
STRING (EMBL)DENND4A
ZODIACDENND4A
Ontologies - Pathways
QuickGOQ7Z401
Ontology : AmiGODNA binding  nucleus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  positive regulation of GTPase activity  membrane organization  
Ontology : EGO-EBIDNA binding  nucleus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  positive regulation of GTPase activity  membrane organization  
NDEx NetworkDENND4A
Atlas of Cancer Signalling NetworkDENND4A
Wikipedia pathwaysDENND4A
Orthology - Evolution
OrthoDB10260
GeneTree (enSembl)ENSG00000174485
Phylogenetic Trees/Animal Genes : TreeFamDENND4A
HOVERGENQ7Z401
HOGENOMQ7Z401
Homologs : HomoloGeneDENND4A
Homology/Alignments : Family Browser (UCSC)DENND4A
Gene fusions - Rearrangements
Fusion : MitelmanDENND4A/RAB11A [15q22.31/15q22.31]  
Fusion : MitelmanRAB11A/DENND4A [15q22.31/15q22.31]  [t(15;15)(q22;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND4A
dbVarDENND4A
ClinVarDENND4A
1000_GenomesDENND4A 
Exome Variant ServerDENND4A
ExAC (Exome Aggregation Consortium)DENND4A (select the gene name)
Genetic variants : HAPMAP10260
Genomic Variants (DGV)DENND4A [DGVbeta]
DECIPHERDENND4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND4A 
Mutations
ICGC Data PortalDENND4A 
TCGA Data PortalDENND4A 
Broad Tumor PortalDENND4A
OASIS PortalDENND4A [ Somatic mutations - Copy number]
DENND4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDENND4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND4A
DgiDB (Drug Gene Interaction Database)DENND4A
DoCM (Curated mutations)DENND4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND4A (select a term)
intoGenDENND4A
Cancer3DDENND4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600382   
Orphanet
MedgenDENND4A
Genetic Testing Registry DENND4A
NextProtQ7Z401 [Medical]
TSGene10260
GENETestsDENND4A
Target ValidationDENND4A
Huge Navigator DENND4A [HugePedia]
snp3D : Map Gene to Disease10260
BioCentury BCIQDENND4A
ClinGenDENND4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10260
Chemical/Pharm GKB GenePA134887513
Clinical trialDENND4A
Miscellaneous
canSAR (ICR)DENND4A (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND4A
EVEXDENND4A
GoPubMedDENND4A
iHOPDENND4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:05:10 CEST 2017

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