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DENND4B (DENN domain containing 4B)

Identity

Alias_namesKIAA0476
KIAA0476
DENN/MADD domain containing 4B
Other alias
HGNC (Hugo) DENND4B
LocusID (NCBI) 9909
Atlas_Id 62432
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 153929501 and ends at 153946678 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DENND4B (1q21.3) / BLMH (17q11.2)DENND4B (1q21.3) / DENND4B (1q21.3)DENND4B (1q21.3) / DHCR7 (11q13.4)
DENND4B (1q21.3) / NUP210L (1q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DENND4B   29044
Cards
Entrez_Gene (NCBI)DENND4B  9909  DENN domain containing 4B
AliasesKIAA0476
GeneCards (Weizmann)DENND4B
Ensembl hg19 (Hinxton)ENSG00000198837 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198837 [Gene_View]  chr1:153929501-153946678 [Contig_View]  DENND4B [Vega]
ICGC DataPortalENSG00000198837
TCGA cBioPortalDENND4B
AceView (NCBI)DENND4B
Genatlas (Paris)DENND4B
WikiGenes9909
SOURCE (Princeton)DENND4B
Genetics Home Reference (NIH)DENND4B
Genomic and cartography
GoldenPath hg38 (UCSC)DENND4B  -     chr1:153929501-153946678 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND4B  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblDENND4B - 1q21.3 [CytoView hg19]  DENND4B - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIDENND4B [Mapview hg19]  DENND4B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB007945 AK124049 AK129713 AK226053 AL512734
RefSeq transcript (Entrez)NM_014856
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DENND4B
Cluster EST : UnigeneHs.744878 [ NCBI ]
CGAP (NCI)Hs.744878
Alternative Splicing GalleryENSG00000198837
Gene ExpressionDENND4B [ NCBI-GEO ]   DENND4B [ EBI - ARRAY_EXPRESS ]   DENND4B [ SEEK ]   DENND4B [ MEM ]
Gene Expression Viewer (FireBrowse)DENND4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9909
GTEX Portal (Tissue expression)DENND4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75064   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75064  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75064
Splice isoforms : SwissVarO75064
PhosPhoSitePlusO75064
Domaine pattern : Prosite (Expaxy)DDENN (PS50947)    DENN (PS50211)    MABP (PS51498)    PPR (PS51375)    UDENN (PS50946)   
Domains : Interpro (EBI)dDENN_dom    DENN_dom    MABP    Pentatricopeptide_repeat    uDENN_dom   
Domain families : Pfam (Sanger)dDENN (PF03455)    DENN (PF02141)    uDENN (PF03456)   
Domain families : Pfam (NCBI)pfam03455    pfam02141    pfam03456   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  uDENN (SM00800)  
Conserved Domain (NCBI)DENND4B
DMDM Disease mutations9909
Blocks (Seattle)DENND4B
SuperfamilyO75064
Human Protein AtlasENSG00000198837
Peptide AtlasO75064
IPIIPI00847759   IPI00973822   IPI00976769   
Protein Interaction databases
DIP (DOE-UCLA)O75064
IntAct (EBI)O75064
FunCoupENSG00000198837
BioGRIDDENND4B
STRING (EMBL)DENND4B
ZODIACDENND4B
Ontologies - Pathways
QuickGOO75064
Ontology : AmiGOnucleus  Golgi apparatus  cytosol  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  regulation of Rab protein signal transduction  positive regulation of GTPase activity  membrane organization  
Ontology : EGO-EBInucleus  Golgi apparatus  cytosol  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  regulation of Rab protein signal transduction  positive regulation of GTPase activity  membrane organization  
NDEx NetworkDENND4B
Atlas of Cancer Signalling NetworkDENND4B
Wikipedia pathwaysDENND4B
Orthology - Evolution
OrthoDB9909
GeneTree (enSembl)ENSG00000198837
Phylogenetic Trees/Animal Genes : TreeFamDENND4B
HOVERGENO75064
HOGENOMO75064
Homologs : HomoloGeneDENND4B
Homology/Alignments : Family Browser (UCSC)DENND4B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND4B
dbVarDENND4B
ClinVarDENND4B
1000_GenomesDENND4B 
Exome Variant ServerDENND4B
ExAC (Exome Aggregation Consortium)DENND4B (select the gene name)
Genetic variants : HAPMAP9909
Genomic Variants (DGV)DENND4B [DGVbeta]
DECIPHERDENND4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND4B 
Mutations
ICGC Data PortalDENND4B 
TCGA Data PortalDENND4B 
Broad Tumor PortalDENND4B
OASIS PortalDENND4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDENND4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDENND4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND4B
DgiDB (Drug Gene Interaction Database)DENND4B
DoCM (Curated mutations)DENND4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND4B (select a term)
intoGenDENND4B
Cancer3DDENND4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenDENND4B
Genetic Testing Registry DENND4B
NextProtO75064 [Medical]
TSGene9909
GENETestsDENND4B
Target ValidationDENND4B
Huge Navigator DENND4B [HugePedia]
snp3D : Map Gene to Disease9909
BioCentury BCIQDENND4B
ClinGenDENND4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9909
Chemical/Pharm GKB GenePA142671629
Clinical trialDENND4B
Miscellaneous
canSAR (ICR)DENND4B (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND4B
EVEXDENND4B
GoPubMedDENND4B
iHOPDENND4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:06:09 CEST 2017

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