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DENND5A (DENN domain containing 5A)

Identity

Alias_namesRAB6IP1
RAB6 interacting protein 1
DENN/MADD domain containing 5A
Alias_symbol (synonym)KIAA1091
FLJ22354
FLJ33829
FLJ43455
Other aliasEIEE49
HGNC (Hugo) DENND5A
LocusID (NCBI) 23258
Atlas_Id 62433
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 9138826 and ends at 9265326 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DENND5A (11p15.4) / DENND5A (11p15.4)DENND5A (11p15.4) / FN1 (2q35)DENND5A (11p15.4) / PGPEP1L (15q26.3)
DENND5A (11p15.4) / PPFIBP2 (11p15.4)DENND5A (11p15.4) / SBF2 (11p15.4)DENND5A (11p15.4) / TMEM41B (11p15.4)
GAS7 (17p13.1) / DENND5A (11p15.4)IFITM10 (11p15.5) / DENND5A (11p15.4)MAGI3 (1p13.2) / DENND5A (11p15.4)
ST5 (11p15.4) / DENND5A (11p15.4)SV2A (1q21.2) / DENND5A (11p15.4)ZNF266 (19p13.2) / DENND5A (11p15.4)
cytochrome_b () / DENND5A (11p15.4)IFITM10 DENND5AST5 DENND5A
MAGI3 DENND5ADENND5A PGPEP1LDENND5A SBF2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DENND5A   19344
Cards
Entrez_Gene (NCBI)DENND5A  23258  DENN domain containing 5A
AliasesEIEE49; RAB6IP1
GeneCards (Weizmann)DENND5A
Ensembl hg19 (Hinxton)ENSG00000184014 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184014 [Gene_View]  chr11:9138826-9265326 [Contig_View]  DENND5A [Vega]
ICGC DataPortalENSG00000184014
TCGA cBioPortalDENND5A
AceView (NCBI)DENND5A
Genatlas (Paris)DENND5A
WikiGenes23258
SOURCE (Princeton)DENND5A
Genetics Home Reference (NIH)DENND5A
Genomic and cartography
GoldenPath hg38 (UCSC)DENND5A  -     chr11:9138826-9265326 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND5A  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblDENND5A - 11p15.4 [CytoView hg19]  DENND5A - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBIDENND5A [Mapview hg19]  DENND5A [Mapview hg38]
OMIM617278   617281   
Gene and transcription
Genbank (Entrez)AB029014 AK025499 AK026007 AK091148 AK125444
RefSeq transcript (Entrez)NM_001243254 NM_001348748 NM_001348749 NM_001348750 NM_015213
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DENND5A
Cluster EST : UnigeneHs.501857 [ NCBI ]
CGAP (NCI)Hs.501857
Alternative Splicing GalleryENSG00000184014
Gene ExpressionDENND5A [ NCBI-GEO ]   DENND5A [ EBI - ARRAY_EXPRESS ]   DENND5A [ SEEK ]   DENND5A [ MEM ]
Gene Expression Viewer (FireBrowse)DENND5A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23258
GTEX Portal (Tissue expression)DENND5A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IQ26   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IQ26  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IQ26
Splice isoforms : SwissVarQ6IQ26
PhosPhoSitePlusQ6IQ26
Domaine pattern : Prosite (Expaxy)DDENN (PS50947)    DENN (PS50211)    PLAT (PS50095)    RUN (PS50826)    UDENN (PS50946)   
Domains : Interpro (EBI)dDENN_dom    DENN_dom    PLAT/LH2_dom    Run_dom    uDENN_dom   
Domain families : Pfam (Sanger)dDENN (PF03455)    DENN (PF02141)    PLAT (PF01477)    RUN (PF02759)    uDENN (PF03456)   
Domain families : Pfam (NCBI)pfam03455    pfam02141    pfam01477    pfam02759    pfam03456   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  RUN (SM00593)  uDENN (SM00800)  
Conserved Domain (NCBI)DENND5A
DMDM Disease mutations23258
Blocks (Seattle)DENND5A
SuperfamilyQ6IQ26
Human Protein AtlasENSG00000184014
Peptide AtlasQ6IQ26
HPRD11475
IPIIPI00456737   IPI00983329   IPI00975579   IPI00977937   IPI00985072   IPI00976768   IPI00984499   IPI00977240   IPI00983934   IPI00976180   IPI00977324   
Protein Interaction databases
DIP (DOE-UCLA)Q6IQ26
IntAct (EBI)Q6IQ26
FunCoupENSG00000184014
BioGRIDDENND5A
STRING (EMBL)DENND5A
ZODIACDENND5A
Ontologies - Pathways
QuickGOQ6IQ26
Ontology : AmiGOcalcium channel activity  trans-Golgi network  cytosol  negative regulation of neuron projection development  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  Rab GTPase binding  retromer complex  retrograde transport, endosome to Golgi  positive regulation of GTPase activity  detection of mechanical stimulus  membrane organization  calcium ion transmembrane transport  
Ontology : EGO-EBIcalcium channel activity  trans-Golgi network  cytosol  negative regulation of neuron projection development  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  Rab GTPase binding  retromer complex  retrograde transport, endosome to Golgi  positive regulation of GTPase activity  detection of mechanical stimulus  membrane organization  calcium ion transmembrane transport  
NDEx NetworkDENND5A
Atlas of Cancer Signalling NetworkDENND5A
Wikipedia pathwaysDENND5A
Orthology - Evolution
OrthoDB23258
GeneTree (enSembl)ENSG00000184014
Phylogenetic Trees/Animal Genes : TreeFamDENND5A
HOVERGENQ6IQ26
HOGENOMQ6IQ26
Homologs : HomoloGeneDENND5A
Homology/Alignments : Family Browser (UCSC)DENND5A
Gene fusions - Rearrangements
Fusion: TCGAIFITM10 DENND5A
Fusion: TCGAST5 DENND5A
Fusion: TCGAMAGI3 DENND5A
Fusion: TCGADENND5A PGPEP1L
Fusion: TCGADENND5A SBF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND5A
dbVarDENND5A
ClinVarDENND5A
1000_GenomesDENND5A 
Exome Variant ServerDENND5A
ExAC (Exome Aggregation Consortium)DENND5A (select the gene name)
Genetic variants : HAPMAP23258
Genomic Variants (DGV)DENND5A [DGVbeta]
DECIPHERDENND5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND5A 
Mutations
ICGC Data PortalDENND5A 
TCGA Data PortalDENND5A 
Broad Tumor PortalDENND5A
OASIS PortalDENND5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDENND5A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDENND5A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND5A
DgiDB (Drug Gene Interaction Database)DENND5A
DoCM (Curated mutations)DENND5A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND5A (select a term)
intoGenDENND5A
Cancer3DDENND5A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617278    617281   
Orphanet
MedgenDENND5A
Genetic Testing Registry DENND5A
NextProtQ6IQ26 [Medical]
TSGene23258
GENETestsDENND5A
Target ValidationDENND5A
Huge Navigator DENND5A [HugePedia]
snp3D : Map Gene to Disease23258
BioCentury BCIQDENND5A
ClinGenDENND5A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23258
Chemical/Pharm GKB GenePA164718737
Clinical trialDENND5A
Miscellaneous
canSAR (ICR)DENND5A (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND5A
EVEXDENND5A
GoPubMedDENND5A
iHOPDENND5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:06:09 CEST 2017

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