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DENND5B (DENN domain containing 5B)

Identity

Alias_namesDENN/MADD domain containing 5B
Alias_symbol (synonym)MGC24039
Other alias-
HGNC (Hugo) DENND5B
LocusID (NCBI) 160518
Atlas_Id 54252
Location 12p11.21  [Link to chromosome band 12p11]
Location_base_pair Starts at 31535157 and ends at 31743376 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CEPT1 (1p13.3) / DENND5B (12p11.21)DENND5B (12p11.21) / BCL7B (7q11.23)DENND5B (12p11.21) / NUP54 (4q21.1)
DENND5B (12p11.21) / PIGT (20q13.12)DENND5B (12p11.21) / PLCZ1 (12p12.3)GALNT18 (11p15.3) / DENND5B (12p11.21)
LRRC75A-AS1 (17p11.2) / DENND5B (12p11.21)DENND5B 12p11.21 / NUP54 4q21.1DENND5B 12p11.21 / PLCZ1 12p12.3
GALNTL4 DENND5B 12p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DENND5B   28338
Cards
Entrez_Gene (NCBI)DENND5B  160518  DENN domain containing 5B
Aliases
GeneCards (Weizmann)DENND5B
Ensembl hg19 (Hinxton)ENSG00000170456 [Gene_View]  chr12:31535157-31743376 [Contig_View]  DENND5B [Vega]
Ensembl hg38 (Hinxton)ENSG00000170456 [Gene_View]  chr12:31535157-31743376 [Contig_View]  DENND5B [Vega]
ICGC DataPortalENSG00000170456
TCGA cBioPortalDENND5B
AceView (NCBI)DENND5B
Genatlas (Paris)DENND5B
WikiGenes160518
SOURCE (Princeton)DENND5B
Genetics Home Reference (NIH)DENND5B
Genomic and cartography
GoldenPath hg19 (UCSC)DENND5B  -     chr12:31535157-31743376 -  12p11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DENND5B  -     12p11.21   [Description]    (hg38-Dec_2013)
EnsemblDENND5B - 12p11.21 [CytoView hg19]  DENND5B - 12p11.21 [CytoView hg38]
Mapping of homologs : NCBIDENND5B [Mapview hg19]  DENND5B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB209341 AF086301 AI762929 AI858532 AK021465
RefSeq transcript (Entrez)NM_001308339 NM_144973
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)DENND5B
Cluster EST : UnigeneHs.118166 [ NCBI ]
CGAP (NCI)Hs.118166
Alternative Splicing GalleryENSG00000170456
Gene ExpressionDENND5B [ NCBI-GEO ]   DENND5B [ EBI - ARRAY_EXPRESS ]   DENND5B [ SEEK ]   DENND5B [ MEM ]
Gene Expression Viewer (FireBrowse)DENND5B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)160518
GTEX Portal (Tissue expression)DENND5B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZUT9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZUT9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZUT9
Splice isoforms : SwissVarQ6ZUT9
PhosPhoSitePlusQ6ZUT9
Domaine pattern : Prosite (Expaxy)DDENN (PS50947)    DENN (PS50211)    PLAT (PS50095)    RUN (PS50826)    UDENN (PS50946)   
Domains : Interpro (EBI)dDENN_dom    DENN_dom    PLAT/LH2_dom    Run_dom    uDENN_dom   
Domain families : Pfam (Sanger)dDENN (PF03455)    DENN (PF02141)    PLAT (PF01477)    RUN (PF02759)    uDENN (PF03456)   
Domain families : Pfam (NCBI)pfam03455    pfam02141    pfam01477    pfam02759    pfam03456   
Domain families : Smart (EMBL)dDENN (SM00801)  DENN (SM00799)  RUN (SM00593)  uDENN (SM00800)  
Conserved Domain (NCBI)DENND5B
DMDM Disease mutations160518
Blocks (Seattle)DENND5B
SuperfamilyQ6ZUT9
Human Protein AtlasENSG00000170456
Peptide AtlasQ6ZUT9
HPRD11321
IPIIPI00783238   IPI00419084   IPI00746579   IPI00744836   IPI01013796   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZUT9
IntAct (EBI)Q6ZUT9
FunCoupENSG00000170456
BioGRIDDENND5B
STRING (EMBL)DENND5B
ZODIACDENND5B
Ontologies - Pathways
QuickGOQ6ZUT9
Ontology : AmiGOcalcium channel activity  membrane  integral component of membrane  Rab guanyl-nucleotide exchange factor activity  positive regulation of GTPase activity  positive regulation of GTPase activity  detection of mechanical stimulus  calcium ion transmembrane transport  
Ontology : EGO-EBIcalcium channel activity  membrane  integral component of membrane  Rab guanyl-nucleotide exchange factor activity  positive regulation of GTPase activity  positive regulation of GTPase activity  detection of mechanical stimulus  calcium ion transmembrane transport  
NDEx NetworkDENND5B
Atlas of Cancer Signalling NetworkDENND5B
Wikipedia pathwaysDENND5B
Orthology - Evolution
OrthoDB160518
GeneTree (enSembl)ENSG00000170456
Phylogenetic Trees/Animal Genes : TreeFamDENND5B
HOVERGENQ6ZUT9
HOGENOMQ6ZUT9
Homologs : HomoloGeneDENND5B
Homology/Alignments : Family Browser (UCSC)DENND5B
Gene fusions - Rearrangements
Fusion : MitelmanCEPT1/DENND5B [1p13.3/12p11.21]  [t(1;12)(p13;p11)]  
Fusion : MitelmanDENND5B/NUP54 [12p11.21/4q21.1]  [t(4;12)(q21;p11)]  
Fusion : MitelmanDENND5B/PLCZ1 [12p11.21/12p12.3]  [t(12;12)(p11;p12)]  
Fusion : MitelmanGALNT18/DENND5B [11p15.3/12p11.21]  [t(11;12)(p15;p11)]  
Fusion: TCGADENND5B 12p11.21 NUP54 4q21.1 BRCA
Fusion: TCGADENND5B 12p11.21 PLCZ1 12p12.3 LGG
Fusion: TCGAGALNTL4 DENND5B 12p11.21 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND5B
dbVarDENND5B
ClinVarDENND5B
1000_GenomesDENND5B 
Exome Variant ServerDENND5B
ExAC (Exome Aggregation Consortium)DENND5B (select the gene name)
Genetic variants : HAPMAP160518
Genomic Variants (DGV)DENND5B [DGVbeta]
DECIPHER (Syndromes)12:31535157-31743376  ENSG00000170456
CONAN: Copy Number AnalysisDENND5B 
Mutations
ICGC Data PortalDENND5B 
TCGA Data PortalDENND5B 
Broad Tumor PortalDENND5B
OASIS PortalDENND5B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDENND5B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDENND5B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND5B
DgiDB (Drug Gene Interaction Database)DENND5B
DoCM (Curated mutations)DENND5B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND5B (select a term)
intoGenDENND5B
Cancer3DDENND5B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenDENND5B
Genetic Testing Registry DENND5B
NextProtQ6ZUT9 [Medical]
TSGene160518
GENETestsDENND5B
Huge Navigator DENND5B [HugePedia]
snp3D : Map Gene to Disease160518
BioCentury BCIQDENND5B
ClinGenDENND5B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD160518
Chemical/Pharm GKB GenePA164718788
Clinical trialDENND5B
Miscellaneous
canSAR (ICR)DENND5B (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND5B
EVEXDENND5B
GoPubMedDENND5B
iHOPDENND5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:03:06 CET 2017

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