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DENND6B (DENN/MADD domain containing 6B)

Identity

Alias_namesFAM116B
family with sequence similarity 116, member B
DENN/MADD domain containing 6B
Alias_symbol (synonym)MGC33692
AFI1B
Other alias
HGNC (Hugo) DENND6B
LocusID (NCBI) 414918
Atlas_Id 62436
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50750392 and ends at 50765489 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ZNF786 (7q36.1) / DENND6B (22q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DENND6B   32690
Cards
Entrez_Gene (NCBI)DENND6B  414918  DENN/MADD domain containing 6B
AliasesAFI1B; FAM116B
GeneCards (Weizmann)DENND6B
Ensembl hg19 (Hinxton) [Gene_View]  chr22:50750392-50765489 [Contig_View]  DENND6B [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr22:50750392-50765489 [Contig_View]  DENND6B [Vega]
TCGA cBioPortalDENND6B
AceView (NCBI)DENND6B
Genatlas (Paris)DENND6B
WikiGenes414918
SOURCE (Princeton)DENND6B
Genetics Home Reference (NIH)DENND6B
Genomic and cartography
GoldenPath hg19 (UCSC)DENND6B  -     chr22:50750392-50765489 -  22q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DENND6B  -     22q13.33   [Description]    (hg38-Dec_2013)
EnsemblDENND6B - 22q13.33 [CytoView hg19]  DENND6B - 22q13.33 [CytoView hg38]
Mapping of homologs : NCBIDENND6B [Mapview hg19]  DENND6B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA864612 AK054743 BC031069 BI758775 BM981037
RefSeq transcript (Entrez)NM_001001794
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011526 NW_004929431
Consensus coding sequences : CCDS (NCBI)DENND6B
Cluster EST : UnigeneHs.530380 [ NCBI ]
CGAP (NCI)Hs.530380
Gene ExpressionDENND6B [ NCBI-GEO ]   DENND6B [ EBI - ARRAY_EXPRESS ]   DENND6B [ SEEK ]   DENND6B [ MEM ]
Gene Expression Viewer (FireBrowse)DENND6B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)414918
GTEX Portal (Tissue expression)DENND6B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NEG7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NEG7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NEG7
Splice isoforms : SwissVarQ8NEG7
PhosPhoSitePlusQ8NEG7
Domains : Interpro (EBI)ABL9/DENND6_dom    DENND6   
Domain families : Pfam (Sanger)Avl9 (PF09794)   
Domain families : Pfam (NCBI)pfam09794   
Conserved Domain (NCBI)DENND6B
DMDM Disease mutations414918
Blocks (Seattle)DENND6B
SuperfamilyQ8NEG7
Peptide AtlasQ8NEG7
HPRD17526
IPIIPI00386146   IPI00852621   
Protein Interaction databases
DIP (DOE-UCLA)Q8NEG7
IntAct (EBI)Q8NEG7
BioGRIDDENND6B
STRING (EMBL)DENND6B
ZODIACDENND6B
Ontologies - Pathways
QuickGOQ8NEG7
Ontology : AmiGORab guanyl-nucleotide exchange factor activity  positive regulation of GTPase activity  positive regulation of GTPase activity  recycling endosome  
Ontology : EGO-EBIRab guanyl-nucleotide exchange factor activity  positive regulation of GTPase activity  positive regulation of GTPase activity  recycling endosome  
NDEx NetworkDENND6B
Atlas of Cancer Signalling NetworkDENND6B
Wikipedia pathwaysDENND6B
Orthology - Evolution
OrthoDB414918
Phylogenetic Trees/Animal Genes : TreeFamDENND6B
HOVERGENQ8NEG7
HOGENOMQ8NEG7
Homologs : HomoloGeneDENND6B
Homology/Alignments : Family Browser (UCSC)DENND6B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND6B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND6B
dbVarDENND6B
ClinVarDENND6B
1000_GenomesDENND6B 
Exome Variant ServerDENND6B
ExAC (Exome Aggregation Consortium)DENND6B (select the gene name)
Genetic variants : HAPMAP414918
Genomic Variants (DGV)DENND6B [DGVbeta]
DECIPHER (Syndromes)22:50750392-50765489  
CONAN: Copy Number AnalysisDENND6B 
Mutations
ICGC Data PortalDENND6B 
TCGA Data PortalDENND6B 
Broad Tumor PortalDENND6B
OASIS PortalDENND6B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDENND6B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND6B
DgiDB (Drug Gene Interaction Database)DENND6B
DoCM (Curated mutations)DENND6B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND6B (select a term)
intoGenDENND6B
Cancer3DDENND6B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenDENND6B
Genetic Testing Registry DENND6B
NextProtQ8NEG7 [Medical]
TSGene414918
GENETestsDENND6B
Huge Navigator DENND6B [HugePedia]
snp3D : Map Gene to Disease414918
BioCentury BCIQDENND6B
ClinGenDENND6B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD414918
Chemical/Pharm GKB GenePA144596432
Clinical trialDENND6B
Miscellaneous
canSAR (ICR)DENND6B (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND6B
EVEXDENND6B
GoPubMedDENND6B
iHOPDENND6B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:01:31 CET 2017

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