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DEPDC1 (DEP domain containing 1)

Identity

Alias_symbol (synonym)DEP.8
FLJ20354
SDP35
DEPDC1A
Other aliasDEPDC1-V2
HGNC (Hugo) DEPDC1
LocusID (NCBI) 55635
Atlas_Id 55477
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 68474152 and ends at 68497221 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;11)(p31;q23) DEPDC1/NNMT

External links

Nomenclature
HGNC (Hugo)DEPDC1   22949
Cards
Entrez_Gene (NCBI)DEPDC1  55635  DEP domain containing 1
AliasesDEP.8; DEPDC1-V2; DEPDC1A; SDP35
GeneCards (Weizmann)DEPDC1
Ensembl hg19 (Hinxton)ENSG00000024526 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000024526 [Gene_View]  ENSG00000024526 [Sequence]  chr1:68474152-68497221 [Contig_View]  DEPDC1 [Vega]
ICGC DataPortalENSG00000024526
TCGA cBioPortalDEPDC1
AceView (NCBI)DEPDC1
Genatlas (Paris)DEPDC1
WikiGenes55635
SOURCE (Princeton)DEPDC1
Genetics Home Reference (NIH)DEPDC1
Genomic and cartography
GoldenPath hg38 (UCSC)DEPDC1  -     chr1:68474152-68497221 -  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DEPDC1  -     1p31.3   [Description]    (hg19-Feb_2009)
EnsemblDEPDC1 - 1p31.3 [CytoView hg19]  DEPDC1 - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBIDEPDC1 [Mapview hg19]  DEPDC1 [Mapview hg38]
OMIM612002   
Gene and transcription
Genbank (Entrez)AB281187 AB281274 AJ278112 AK000361 AK000490
RefSeq transcript (Entrez)NM_001114120 NM_017779
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DEPDC1
Cluster EST : UnigeneHs.445098 [ NCBI ]
CGAP (NCI)Hs.445098
Alternative Splicing GalleryENSG00000024526
Gene ExpressionDEPDC1 [ NCBI-GEO ]   DEPDC1 [ EBI - ARRAY_EXPRESS ]   DEPDC1 [ SEEK ]   DEPDC1 [ MEM ]
Gene Expression Viewer (FireBrowse)DEPDC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55635
GTEX Portal (Tissue expression)DEPDC1
Human Protein AtlasENSG00000024526-DEPDC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TB30   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5TB30  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TB30
Splice isoforms : SwissVarQ5TB30
PhosPhoSitePlusQ5TB30
Domaine pattern : Prosite (Expaxy)DEP (PS50186)   
Domains : Interpro (EBI)DEP_dom    Rho_GTPase_activation_prot    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)DEP (PF00610)   
Domain families : Pfam (NCBI)pfam00610   
Domain families : Smart (EMBL)DEP (SM00049)  
Conserved Domain (NCBI)DEPDC1
DMDM Disease mutations55635
Blocks (Seattle)DEPDC1
PDB (RSDB)2YSR   
PDB Europe2YSR   
PDB (PDBSum)2YSR   
PDB (IMB)2YSR   
Structural Biology KnowledgeBase2YSR   
SCOP (Structural Classification of Proteins)2YSR   
CATH (Classification of proteins structures)2YSR   
SuperfamilyQ5TB30
Human Protein Atlas [tissue]ENSG00000024526-DEPDC1 [tissue]
Peptide AtlasQ5TB30
HPRD10879
IPIIPI00016922   IPI00902667   IPI00952603   IPI00160716   IPI00977863   
Protein Interaction databases
DIP (DOE-UCLA)Q5TB30
IntAct (EBI)Q5TB30
FunCoupENSG00000024526
BioGRIDDEPDC1
STRING (EMBL)DEPDC1
ZODIACDEPDC1
Ontologies - Pathways
QuickGOQ5TB30
Ontology : AmiGOGTPase activator activity  protein binding  nucleus  nucleus  transcriptional repressor complex  transcriptional repressor complex  intracellular signal transduction  positive regulation of GTPase activity  negative regulation of transcription, DNA-templated  
Ontology : EGO-EBIGTPase activator activity  protein binding  nucleus  nucleus  transcriptional repressor complex  transcriptional repressor complex  intracellular signal transduction  positive regulation of GTPase activity  negative regulation of transcription, DNA-templated  
NDEx NetworkDEPDC1
Atlas of Cancer Signalling NetworkDEPDC1
Wikipedia pathwaysDEPDC1
Orthology - Evolution
OrthoDB55635
GeneTree (enSembl)ENSG00000024526
Phylogenetic Trees/Animal Genes : TreeFamDEPDC1
HOGENOMQ5TB30
Homologs : HomoloGeneDEPDC1
Homology/Alignments : Family Browser (UCSC)DEPDC1
Gene fusions - Rearrangements
Fusion : QuiverDEPDC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDEPDC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DEPDC1
dbVarDEPDC1
ClinVarDEPDC1
1000_GenomesDEPDC1 
Exome Variant ServerDEPDC1
ExAC (Exome Aggregation Consortium)ENSG00000024526
GNOMAD BrowserENSG00000024526
Varsome BrowserDEPDC1
Genetic variants : HAPMAP55635
Genomic Variants (DGV)DEPDC1 [DGVbeta]
DECIPHERDEPDC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDEPDC1 
Mutations
ICGC Data PortalDEPDC1 
TCGA Data PortalDEPDC1 
Broad Tumor PortalDEPDC1
OASIS PortalDEPDC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDEPDC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDEPDC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DEPDC1
DgiDB (Drug Gene Interaction Database)DEPDC1
DoCM (Curated mutations)DEPDC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DEPDC1 (select a term)
intoGenDEPDC1
Cancer3DDEPDC1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612002   
Orphanet
DisGeNETDEPDC1
MedgenDEPDC1
Genetic Testing Registry DEPDC1
NextProtQ5TB30 [Medical]
TSGene55635
GENETestsDEPDC1
Target ValidationDEPDC1
Huge Navigator DEPDC1 [HugePedia]
snp3D : Map Gene to Disease55635
BioCentury BCIQDEPDC1
ClinGenDEPDC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55635
Chemical/Pharm GKB GenePA134974825
Clinical trialDEPDC1
Miscellaneous
canSAR (ICR)DEPDC1 (select the gene name)
DataMed IndexDEPDC1
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDEPDC1
EVEXDEPDC1
GoPubMedDEPDC1
iHOPDEPDC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Feb 14 16:26:55 CET 2019
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