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DEPDC1B (DEP domain containing 1B)

Identity

Alias (NCBI)BRCC3
XTP1
HGNC (Hugo) DEPDC1B
HGNC Alias symbXTP1
BRCC3
HGNC Alias namebreast cancer cell 3
LocusID (NCBI) 55789
Atlas_Id 52992
Location 5q12.1  [Link to chromosome band 5q12]
Location_base_pair Starts at 60596912 and ends at 60700166 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD34 (1q32.2) / DEPDC1B (5q12.1)DEPDC1B (5q12.1) / ELOVL7 (5q12.1)DEPDC1B (5q12.1) / FUNDC2 (Xq28)
DEPDC1B (5q12.1) / HSD17B12 (11p11.2)DEPDC1B (5q12.1) / PDE4D (5q11.2)DEPDC1B (5q12.1) / RSPH14 (22q11.22)
PDE4D (5q11.2) / DEPDC1B (5q12.1)PDE4D 5q11.2 / DEPDC1B 5q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DEPDC1B   24902
Cards
Entrez_Gene (NCBI)DEPDC1B    DEP domain containing 1B
AliasesBRCC3; XTP1
GeneCards (Weizmann)DEPDC1B
Ensembl hg19 (Hinxton)ENSG00000035499 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000035499 [Gene_View]  ENSG00000035499 [Sequence]  chr5:60596912-60700166 [Contig_View]  DEPDC1B [Vega]
ICGC DataPortalENSG00000035499
TCGA cBioPortalDEPDC1B
AceView (NCBI)DEPDC1B
Genatlas (Paris)DEPDC1B
SOURCE (Princeton)DEPDC1B
Genetics Home Reference (NIH)DEPDC1B
Genomic and cartography
GoldenPath hg38 (UCSC)DEPDC1B  -     chr5:60596912-60700166 -  5q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DEPDC1B  -     5q12.1   [Description]    (hg19-Feb_2009)
GoldenPathDEPDC1B - 5q12.1 [CytoView hg19]  DEPDC1B - 5q12.1 [CytoView hg38]
ImmunoBaseENSG00000035499
Genome Data Viewer NCBIDEPDC1B [Mapview hg19]  
OMIM616073   
Gene and transcription
Genbank (Entrez)AA830503 AF303178 AF488828 AF490257 AK001166
RefSeq transcript (Entrez)NM_001145208 NM_018369
Consensus coding sequences : CCDS (NCBI)DEPDC1B
Gene ExpressionDEPDC1B [ NCBI-GEO ]   DEPDC1B [ EBI - ARRAY_EXPRESS ]   DEPDC1B [ SEEK ]   DEPDC1B [ MEM ]
Gene Expression Viewer (FireBrowse)DEPDC1B [ Firebrowse - Broad ]
GenevisibleExpression of DEPDC1B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55789
GTEX Portal (Tissue expression)DEPDC1B
Human Protein AtlasENSG00000035499-DEPDC1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WUY9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WUY9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WUY9
PhosPhoSitePlusQ8WUY9
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    RHOGAP (PS50238)   
Domains : Interpro (EBI)DEP_dom    Rho_GTPase_activation_prot    RhoGAP_dom    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)DEP (PF00610)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00610    pfam00620   
Domain families : Smart (EMBL)DEP (SM00049)  
Conserved Domain (NCBI)DEPDC1B
SuperfamilyQ8WUY9
AlphaFold pdb e-kbQ8WUY9   
Human Protein Atlas [tissue]ENSG00000035499-DEPDC1B [tissue]
HPRD16794
Protein Interaction databases
DIP (DOE-UCLA)Q8WUY9
IntAct (EBI)Q8WUY9
BioGRIDDEPDC1B
STRING (EMBL)DEPDC1B
ZODIACDEPDC1B
Ontologies - Pathways
QuickGOQ8WUY9
Ontology : AmiGOGTPase activator activity  cytosol  cell migration  positive regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  intracellular signal transduction  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  cytosol  cell migration  positive regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  intracellular signal transduction  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  
NDEx NetworkDEPDC1B
Atlas of Cancer Signalling NetworkDEPDC1B
Wikipedia pathwaysDEPDC1B
Orthology - Evolution
OrthoDB55789
GeneTree (enSembl)ENSG00000035499
Phylogenetic Trees/Animal Genes : TreeFamDEPDC1B
Homologs : HomoloGeneDEPDC1B
Homology/Alignments : Family Browser (UCSC)DEPDC1B
Gene fusions - Rearrangements
Fusion : MitelmanDEPDC1B/ELOVL7 [5q12.1/5q12.1]  
Fusion : MitelmanPDE4D/DEPDC1B [5q11.2/5q12.1]  
Fusion : QuiverDEPDC1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDEPDC1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DEPDC1B
dbVarDEPDC1B
ClinVarDEPDC1B
MonarchDEPDC1B
1000_GenomesDEPDC1B 
Exome Variant ServerDEPDC1B
GNOMAD BrowserENSG00000035499
Varsome BrowserDEPDC1B
ACMGDEPDC1B variants
VarityQ8WUY9
Genomic Variants (DGV)DEPDC1B [DGVbeta]
DECIPHERDEPDC1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDEPDC1B 
Mutations
ICGC Data PortalDEPDC1B 
TCGA Data PortalDEPDC1B 
Broad Tumor PortalDEPDC1B
OASIS PortalDEPDC1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDEPDC1B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDEPDC1B
Mutations and Diseases : HGMDDEPDC1B
intOGen PortalDEPDC1B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDEPDC1B
DgiDB (Drug Gene Interaction Database)DEPDC1B
DoCM (Curated mutations)DEPDC1B
CIViC (Clinical Interpretations of Variants in Cancer)DEPDC1B
Cancer3DDEPDC1B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616073   
Orphanet
DisGeNETDEPDC1B
MedgenDEPDC1B
Genetic Testing Registry DEPDC1B
NextProtQ8WUY9 [Medical]
GENETestsDEPDC1B
Target ValidationDEPDC1B
Huge Navigator DEPDC1B [HugePedia]
ClinGenDEPDC1B
Clinical trials, drugs, therapy
MyCancerGenomeDEPDC1B
Protein Interactions : CTDDEPDC1B
Pharm GKB GenePA134941087
PharosQ8WUY9
Clinical trialDEPDC1B
Miscellaneous
canSAR (ICR)DEPDC1B
HarmonizomeDEPDC1B
DataMed IndexDEPDC1B
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDEPDC1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:06:33 CEST 2021

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