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DEPDC1B (DEP domain containing 1B)

Identity

Alias_symbol (synonym)XTP1
BRCC3
Other alias
HGNC (Hugo) DEPDC1B
LocusID (NCBI) 55789
Atlas_Id 52992
Location 5q12.1  [Link to chromosome band 5q12]
Location_base_pair Starts at 60596912 and ends at 60700166 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CD34 (1q32.2) / DEPDC1B (5q12.1)DEPDC1B (5q12.1) / ELOVL7 (5q12.1)DEPDC1B (5q12.1) / FUNDC2 (Xq28)
DEPDC1B (5q12.1) / HSD17B12 (11p11.2)DEPDC1B (5q12.1) / PDE4D (5q11.2)DEPDC1B (5q12.1) / RSPH14 (22q11.22)
PDE4D (5q11.2) / DEPDC1B (5q12.1)PDE4D 5q11.2 / DEPDC1B 5q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DEPDC1B   24902
Cards
Entrez_Gene (NCBI)DEPDC1B  55789  DEP domain containing 1B
AliasesBRCC3; XTP1
GeneCards (Weizmann)DEPDC1B
Ensembl hg19 (Hinxton)ENSG00000035499 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000035499 [Gene_View]  chr5:60596912-60700166 [Contig_View]  DEPDC1B [Vega]
ICGC DataPortalENSG00000035499
TCGA cBioPortalDEPDC1B
AceView (NCBI)DEPDC1B
Genatlas (Paris)DEPDC1B
WikiGenes55789
SOURCE (Princeton)DEPDC1B
Genetics Home Reference (NIH)DEPDC1B
Genomic and cartography
GoldenPath hg38 (UCSC)DEPDC1B  -     chr5:60596912-60700166 -  5q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DEPDC1B  -     5q12.1   [Description]    (hg19-Feb_2009)
EnsemblDEPDC1B - 5q12.1 [CytoView hg19]  DEPDC1B - 5q12.1 [CytoView hg38]
Mapping of homologs : NCBIDEPDC1B [Mapview hg19]  DEPDC1B [Mapview hg38]
OMIM616073   
Gene and transcription
Genbank (Entrez)AA830503 AF303178 AF488828 AF490257 AK001166
RefSeq transcript (Entrez)NM_001145208 NM_018369
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DEPDC1B
Cluster EST : UnigeneHs.482233 [ NCBI ]
CGAP (NCI)Hs.482233
Alternative Splicing GalleryENSG00000035499
Gene ExpressionDEPDC1B [ NCBI-GEO ]   DEPDC1B [ EBI - ARRAY_EXPRESS ]   DEPDC1B [ SEEK ]   DEPDC1B [ MEM ]
Gene Expression Viewer (FireBrowse)DEPDC1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55789
GTEX Portal (Tissue expression)DEPDC1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WUY9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WUY9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WUY9
Splice isoforms : SwissVarQ8WUY9
PhosPhoSitePlusQ8WUY9
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    RHOGAP (PS50238)   
Domains : Interpro (EBI)DEP_dom    Rho_GTPase_activation_prot    RhoGAP_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DEP (PF00610)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00610    pfam00620   
Domain families : Smart (EMBL)DEP (SM00049)  
Conserved Domain (NCBI)DEPDC1B
DMDM Disease mutations55789
Blocks (Seattle)DEPDC1B
SuperfamilyQ8WUY9
Human Protein AtlasENSG00000035499
Peptide AtlasQ8WUY9
HPRD16794
IPIIPI00293897   IPI01015343   IPI00909567   IPI00966000   IPI00965729   
Protein Interaction databases
DIP (DOE-UCLA)Q8WUY9
IntAct (EBI)Q8WUY9
FunCoupENSG00000035499
BioGRIDDEPDC1B
STRING (EMBL)DEPDC1B
ZODIACDEPDC1B
Ontologies - Pathways
QuickGOQ8WUY9
Ontology : AmiGOGTPase activator activity  cytosol  cell migration  positive regulation of Wnt signaling pathway  intracellular signal transduction  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  cytosol  cell migration  positive regulation of Wnt signaling pathway  intracellular signal transduction  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
NDEx NetworkDEPDC1B
Atlas of Cancer Signalling NetworkDEPDC1B
Wikipedia pathwaysDEPDC1B
Orthology - Evolution
OrthoDB55789
GeneTree (enSembl)ENSG00000035499
Phylogenetic Trees/Animal Genes : TreeFamDEPDC1B
HOVERGENQ8WUY9
HOGENOMQ8WUY9
Homologs : HomoloGeneDEPDC1B
Homology/Alignments : Family Browser (UCSC)DEPDC1B
Gene fusions - Rearrangements
Fusion : MitelmanDEPDC1B/ELOVL7 [5q12.1/5q12.1]  
Fusion : MitelmanPDE4D/DEPDC1B [5q11.2/5q12.1]  [t(5;5)(q12;q12)]  
Fusion: TCGAPDE4D 5q11.2 DEPDC1B 5q12.1 BRCA LUAD LUSC PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDEPDC1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DEPDC1B
dbVarDEPDC1B
ClinVarDEPDC1B
1000_GenomesDEPDC1B 
Exome Variant ServerDEPDC1B
ExAC (Exome Aggregation Consortium)DEPDC1B (select the gene name)
Genetic variants : HAPMAP55789
Genomic Variants (DGV)DEPDC1B [DGVbeta]
DECIPHERDEPDC1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDEPDC1B 
Mutations
ICGC Data PortalDEPDC1B 
TCGA Data PortalDEPDC1B 
Broad Tumor PortalDEPDC1B
OASIS PortalDEPDC1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDEPDC1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDEPDC1B
intOGen PortalDEPDC1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DEPDC1B
DgiDB (Drug Gene Interaction Database)DEPDC1B
DoCM (Curated mutations)DEPDC1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DEPDC1B (select a term)
intoGenDEPDC1B
Cancer3DDEPDC1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616073   
Orphanet
MedgenDEPDC1B
Genetic Testing Registry DEPDC1B
NextProtQ8WUY9 [Medical]
TSGene55789
GENETestsDEPDC1B
Huge Navigator DEPDC1B [HugePedia]
snp3D : Map Gene to Disease55789
BioCentury BCIQDEPDC1B
ClinGenDEPDC1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55789
Chemical/Pharm GKB GenePA134941087
Clinical trialDEPDC1B
Miscellaneous
canSAR (ICR)DEPDC1B (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDEPDC1B
EVEXDEPDC1B
GoPubMedDEPDC1B
iHOPDEPDC1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:13:07 CEST 2017

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