Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DEPDC5 (DEP domain containing 5)

Identity

Alias_symbol (synonym)KIAA0645
DEP.5
Other aliasFFEVF
FFEVF1
HGNC (Hugo) DEPDC5
LocusID (NCBI) 9681
Atlas_Id 52433
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 31754023 and ends at 31815991 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DDX3Y (Yq11.21) / DEPDC5 (22q12.2)DEPDC5 (22q12.2) / CDH19 (18q22.1)DEPDC5 (22q12.2) / CELSR1 (22q13.31)
DEPDC5 (22q12.2) / ENY2 (8q23.1)DEPDC5 (22q12.2) / SFI1 (22q12.2)DRG1 (22q12.2) / DEPDC5 (22q12.2)
DEPDC5 22q12.2 / CDH19 18q22.1DEPDC5 22q12.2 / SFI1 22q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DEPDC5   18423
Cards
Entrez_Gene (NCBI)DEPDC5  9681  DEP domain containing 5
AliasesDEP.5; FFEVF; FFEVF1
GeneCards (Weizmann)DEPDC5
Ensembl hg19 (Hinxton)ENSG00000100150 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100150 [Gene_View]  chr22:31754023-31815991 [Contig_View]  DEPDC5 [Vega]
ICGC DataPortalENSG00000100150
TCGA cBioPortalDEPDC5
AceView (NCBI)DEPDC5
Genatlas (Paris)DEPDC5
WikiGenes9681
SOURCE (Princeton)DEPDC5
Genetics Home Reference (NIH)DEPDC5
Genomic and cartography
GoldenPath hg38 (UCSC)DEPDC5  -     chr22:31754023-31815991 +  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DEPDC5  -     22q12.2   [Description]    (hg19-Feb_2009)
EnsemblDEPDC5 - 22q12.2 [CytoView hg19]  DEPDC5 - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBIDEPDC5 [Mapview hg19]  DEPDC5 [Mapview hg38]
OMIM604364   614191   
Gene and transcription
Genbank (Entrez)AB014545 AJ698950 AJ698951 AJ704764 AK294583
RefSeq transcript (Entrez)NM_001007188 NM_001136029 NM_001242896 NM_001242897 NM_014662
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DEPDC5
Cluster EST : UnigeneHs.435022 [ NCBI ]
CGAP (NCI)Hs.435022
Alternative Splicing GalleryENSG00000100150
Gene ExpressionDEPDC5 [ NCBI-GEO ]   DEPDC5 [ EBI - ARRAY_EXPRESS ]   DEPDC5 [ SEEK ]   DEPDC5 [ MEM ]
Gene Expression Viewer (FireBrowse)DEPDC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9681
GTEX Portal (Tissue expression)DEPDC5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75140   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75140  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75140
Splice isoforms : SwissVarO75140
PhosPhoSitePlusO75140
Domaine pattern : Prosite (Expaxy)DEP (PS50186)   
Domains : Interpro (EBI)DEP_dom    IML1    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DEP (PF00610)    IML1 (PF12257)   
Domain families : Pfam (NCBI)pfam00610    pfam12257   
Domain families : Smart (EMBL)DEP (SM00049)  
Conserved Domain (NCBI)DEPDC5
DMDM Disease mutations9681
Blocks (Seattle)DEPDC5
SuperfamilyO75140
Human Protein AtlasENSG00000100150
Peptide AtlasO75140
HPRD16795
IPIIPI00005665   IPI00553106   IPI00514024   IPI00937821   IPI00479194   IPI00619975   IPI01015171   IPI01015234   IPI00908356   IPI00426066   IPI00952693   IPI00657916   IPI01015621   IPI00853350   IPI00893997   
Protein Interaction databases
DIP (DOE-UCLA)O75140
IntAct (EBI)O75140
FunCoupENSG00000100150
BioGRIDDEPDC5
STRING (EMBL)DEPDC5
ZODIACDEPDC5
Ontologies - Pathways
QuickGOO75140
Ontology : AmiGOGTPase activator activity  lysosome  lysosomal membrane  cytosol  regulation of autophagy  negative regulation of TOR signaling  protein complex binding  cellular response to amino acid starvation  intracellular signal transduction  positive regulation of GTPase activity  perinuclear region of cytoplasm  negative regulation of TORC1 signaling  GATOR1 complex  
Ontology : EGO-EBIGTPase activator activity  lysosome  lysosomal membrane  cytosol  regulation of autophagy  negative regulation of TOR signaling  protein complex binding  cellular response to amino acid starvation  intracellular signal transduction  positive regulation of GTPase activity  perinuclear region of cytoplasm  negative regulation of TORC1 signaling  GATOR1 complex  
NDEx NetworkDEPDC5
Atlas of Cancer Signalling NetworkDEPDC5
Wikipedia pathwaysDEPDC5
Orthology - Evolution
OrthoDB9681
GeneTree (enSembl)ENSG00000100150
Phylogenetic Trees/Animal Genes : TreeFamDEPDC5
HOVERGENO75140
HOGENOMO75140
Homologs : HomoloGeneDEPDC5
Homology/Alignments : Family Browser (UCSC)DEPDC5
Gene fusions - Rearrangements
Fusion : MitelmanDEPDC5/CDH19 [22q12.2/18q22.1]  
Fusion : MitelmanDEPDC5/SFI1 [22q12.2/22q12.2]  [t(22;22)(q12;q12)]  
Fusion: TCGADEPDC5 22q12.2 CDH19 18q22.1 BRCA
Fusion: TCGADEPDC5 22q12.2 SFI1 22q12.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDEPDC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DEPDC5
dbVarDEPDC5
ClinVarDEPDC5
1000_GenomesDEPDC5 
Exome Variant ServerDEPDC5
ExAC (Exome Aggregation Consortium)DEPDC5 (select the gene name)
Genetic variants : HAPMAP9681
Genomic Variants (DGV)DEPDC5 [DGVbeta]
DECIPHERDEPDC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDEPDC5 
Mutations
ICGC Data PortalDEPDC5 
TCGA Data PortalDEPDC5 
Broad Tumor PortalDEPDC5
OASIS PortalDEPDC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDEPDC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDEPDC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DEPDC5
DgiDB (Drug Gene Interaction Database)DEPDC5
DoCM (Curated mutations)DEPDC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DEPDC5 (select a term)
intoGenDEPDC5
Cancer3DDEPDC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604364    614191   
Orphanet13837    13801    14757   
MedgenDEPDC5
Genetic Testing Registry DEPDC5
NextProtO75140 [Medical]
TSGene9681
GENETestsDEPDC5
Huge Navigator DEPDC5 [HugePedia]
snp3D : Map Gene to Disease9681
BioCentury BCIQDEPDC5
ClinGenDEPDC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9681
Chemical/Pharm GKB GenePA134864958
Clinical trialDEPDC5
Miscellaneous
canSAR (ICR)DEPDC5 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDEPDC5
EVEXDEPDC5
GoPubMedDEPDC5
iHOPDEPDC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:13:07 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.