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DEPTOR (DEP domain containing MTOR interacting protein)

Identity

Alias_namesDEPDC6
DEP domain containing 6
Alias_symbol (synonym)DEP.6
FLJ12428
Other alias
HGNC (Hugo) DEPTOR
LocusID (NCBI) 64798
Atlas_Id 51800
Location 10q11.21  [Link to chromosome band 10q11]
Location_base_pair Starts at 119873655 and ends at 120050918 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COL14A1 (8q24.12) / DEPTOR (8q24.12)DDX5 (17q23.3) / DEPTOR (8q24.12)DEPTOR (8q24.12) / DEPTOR (8q24.12)
DEPTOR (8q24.12) / ENPP2 (8q24.12)NSMAF (8q12.1) / DEPTOR (8q24.12)TATDN1 (8q24.13) / DEPTOR (8q24.12)
TRPS1 (8q23.3) / DEPTOR (8q24.12)COL14A1 8q24.12 / DEPTOR 8q24.12DEPTOR 8q24.12 / ENPP2 8q24.12
NSMAF 8q12.1 / DEPTOR 8q24.12TRPS1 8q23.3 / DEPTOR 8q24.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(8;8)(q12;q24) NSMAF/DEPTOR
t(8;8)(q23;q24) TRPS1/DEPTOR
COL14A1/DEPTOR (8q24)
DEPTOR/ENPP2 (8q24)
t(8;17)(q24;q23) DDX5/DEPTOR

External links

Nomenclature
HGNC (Hugo)DEPTOR   22953
Cards
Entrez_Gene (NCBI)DEPTOR  64798  DEP domain containing MTOR interacting protein
AliasesDEP.6; DEPDC6
GeneCards (Weizmann)DEPTOR
Ensembl hg19 (Hinxton)ENSG00000155792 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155792 [Gene_View]  ENSG00000155792 [Sequence]  chr8:119873655-120050918 [Contig_View]  DEPTOR [Vega]
ICGC DataPortalENSG00000155792
TCGA cBioPortalDEPTOR
AceView (NCBI)DEPTOR
Genatlas (Paris)DEPTOR
WikiGenes64798
SOURCE (Princeton)DEPTOR
Genetics Home Reference (NIH)DEPTOR
Genomic and cartography
GoldenPath hg38 (UCSC)DEPTOR  -     chr8:119873655-120050918 +  10q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DEPTOR  -     10q11.21   [Description]    (hg19-Feb_2009)
EnsemblDEPTOR - 10q11.21 [CytoView hg19]  DEPTOR - 10q11.21 [CytoView hg38]
Mapping of homologs : NCBIDEPTOR [Mapview hg19]  DEPTOR [Mapview hg38]
OMIM612974   
Gene and transcription
Genbank (Entrez)AK022403 AK022490 AK023916 AK225168 AK225675
RefSeq transcript (Entrez)NM_001283012 NM_022783
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DEPTOR
Cluster EST : UnigeneHs.112981 [ NCBI ]
CGAP (NCI)Hs.112981
Alternative Splicing GalleryENSG00000155792
Gene ExpressionDEPTOR [ NCBI-GEO ]   DEPTOR [ EBI - ARRAY_EXPRESS ]   DEPTOR [ SEEK ]   DEPTOR [ MEM ]
Gene Expression Viewer (FireBrowse)DEPTOR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64798
GTEX Portal (Tissue expression)DEPTOR
Human Protein AtlasENSG00000155792-DEPTOR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TB45   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TB45  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TB45
Splice isoforms : SwissVarQ8TB45
PhosPhoSitePlusQ8TB45
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    PDZ (PS50106)   
Domains : Interpro (EBI)DEP_dom    DEPTOR    DEPTOR_DEP_1    DEPTOR_DEP_2    PDZ    PDZ_sf    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)DEP (PF00610)   
Domain families : Pfam (NCBI)pfam00610   
Domain families : Smart (EMBL)DEP (SM00049)  PDZ (SM00228)  
Conserved Domain (NCBI)DEPTOR
DMDM Disease mutations64798
Blocks (Seattle)DEPTOR
SuperfamilyQ8TB45
Human Protein Atlas [tissue]ENSG00000155792-DEPTOR [tissue]
Peptide AtlasQ8TB45
HPRD13137
IPIIPI00290560   IPI00908855   
Protein Interaction databases
DIP (DOE-UCLA)Q8TB45
IntAct (EBI)Q8TB45
FunCoupENSG00000155792
BioGRIDDEPTOR
STRING (EMBL)DEPTOR
ZODIACDEPTOR
Ontologies - Pathways
QuickGOQ8TB45
Ontology : AmiGOprotein binding  intracellular  negative regulation of protein kinase activity  negative regulation of TOR signaling  intracellular signal transduction  negative regulation of cell size  regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein binding  intracellular  negative regulation of protein kinase activity  negative regulation of TOR signaling  intracellular signal transduction  negative regulation of cell size  regulation of extrinsic apoptotic signaling pathway  
NDEx NetworkDEPTOR
Atlas of Cancer Signalling NetworkDEPTOR
Wikipedia pathwaysDEPTOR
Orthology - Evolution
OrthoDB64798
GeneTree (enSembl)ENSG00000155792
Phylogenetic Trees/Animal Genes : TreeFamDEPTOR
HOVERGENQ8TB45
HOGENOMQ8TB45
Homologs : HomoloGeneDEPTOR
Homology/Alignments : Family Browser (UCSC)DEPTOR
Gene fusions - Rearrangements
Fusion : MitelmanCOL14A1/DEPTOR [8q24.12/8q24.12]  [t(8;8)(q24;q24)]  
Fusion : MitelmanDDX5/DEPTOR [17q23.3/8q24.12]  [t(8;17)(q24;q23)]  
Fusion : MitelmanDEPTOR/ENPP2 [8q24.12/8q24.12]  [t(8;8)(q24;q24)]  
Fusion : MitelmanNSMAF/DEPTOR [8q12.1/8q24.12]  [t(8;8)(q12;q24)]  
Fusion : MitelmanTRPS1/DEPTOR [8q23.3/8q24.12]  [t(8;8)(q23;q24)]  
Fusion PortalCOL14A1 8q24.12 DEPTOR 8q24.12 LUAD OV
Fusion PortalDEPTOR 8q24.12 ENPP2 8q24.12 BRCA
Fusion PortalNSMAF 8q12.1 DEPTOR 8q24.12 BRCA
Fusion PortalTRPS1 8q23.3 DEPTOR 8q24.12 LGG
Fusion : QuiverDEPTOR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDEPTOR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DEPTOR
dbVarDEPTOR
ClinVarDEPTOR
1000_GenomesDEPTOR 
Exome Variant ServerDEPTOR
ExAC (Exome Aggregation Consortium)ENSG00000155792
GNOMAD BrowserENSG00000155792
Varsome BrowserDEPTOR
Genetic variants : HAPMAP64798
Genomic Variants (DGV)DEPTOR [DGVbeta]
DECIPHERDEPTOR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDEPTOR 
Mutations
ICGC Data PortalDEPTOR 
TCGA Data PortalDEPTOR 
Broad Tumor PortalDEPTOR
OASIS PortalDEPTOR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDEPTOR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDEPTOR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DEPTOR
DgiDB (Drug Gene Interaction Database)DEPTOR
DoCM (Curated mutations)DEPTOR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DEPTOR (select a term)
intoGenDEPTOR
Cancer3DDEPTOR(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612974   
Orphanet
DisGeNETDEPTOR
MedgenDEPTOR
Genetic Testing Registry DEPTOR
NextProtQ8TB45 [Medical]
TSGene64798
GENETestsDEPTOR
Target ValidationDEPTOR
Huge Navigator DEPTOR [HugePedia]
snp3D : Map Gene to Disease64798
BioCentury BCIQDEPTOR
ClinGenDEPTOR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64798
Chemical/Pharm GKB GenePA134897957
Clinical trialDEPTOR
Miscellaneous
canSAR (ICR)DEPTOR (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDEPTOR
EVEXDEPTOR
GoPubMedDEPTOR
iHOPDEPTOR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 10:57:43 CEST 2018
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