DET1 (DET1 partner of COP1 E3 ubiquitin ligase)

2007-04-01  

Identity

HGNC
DET1
LOCATION
15q26.1
LOCUSID
55070
ALIAS
-

Other Information

Locus ID:

NCBI: 55070
MIM: 608727
HGNC: 25477
Ensembl: ENSG00000173867

Variants:

dbSNP: 55070
ClinVar: 55070
TCGA: ENSG00000173867
COSMIC: DET1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173867ENST00000649547A0A024RC56

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
147394642004Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.139
174524402007Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.26
293606412018COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.2

Citation

Dessen P

DET1 (DET1 partner of COP1 E3 ubiquitin ligase)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46887/det1