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DFFA (DNA fragmentation factor subunit alpha)

Identity

Alias_names45 kD
alpha subunit
Alias_symbol (synonym)DFF-45
DFF45
ICAD
DFF1
Other alias
HGNC (Hugo) DFFA
LocusID (NCBI) 1676
Atlas_Id 40297
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 10460546 and ends at 10472556 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CASZ1 (1p36.22) / DFFA (1p36.22)DFFA (1p36.22) / ATP11B (3q26.33)DFFA (1p36.22) / CORT (1p36.22)
DFFA (1p36.22) / DFFA (1p36.22)RPL23 (17q12) / DFFA (1p36.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DFFA   2772
Cards
Entrez_Gene (NCBI)DFFA  1676  DNA fragmentation factor subunit alpha
AliasesDFF-45; DFF1; ICAD
GeneCards (Weizmann)DFFA
Ensembl hg19 (Hinxton)ENSG00000160049 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160049 [Gene_View]  chr1:10460546-10472556 [Contig_View]  DFFA [Vega]
ICGC DataPortalENSG00000160049
TCGA cBioPortalDFFA
AceView (NCBI)DFFA
Genatlas (Paris)DFFA
WikiGenes1676
SOURCE (Princeton)DFFA
Genetics Home Reference (NIH)DFFA
Genomic and cartography
GoldenPath hg38 (UCSC)DFFA  -     chr1:10460546-10472556 -  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DFFA  -     1p36.22   [Description]    (hg19-Feb_2009)
EnsemblDFFA - 1p36.22 [CytoView hg19]  DFFA - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBIDFFA [Mapview hg19]  DFFA [Mapview hg38]
OMIM601882   
Gene and transcription
Genbank (Entrez)AF087573 AF103799 AK222546 AK313317 AU121791
RefSeq transcript (Entrez)NM_004401 NM_213566
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DFFA
Cluster EST : UnigeneHs.484782 [ NCBI ]
CGAP (NCI)Hs.484782
Alternative Splicing GalleryENSG00000160049
Gene ExpressionDFFA [ NCBI-GEO ]   DFFA [ EBI - ARRAY_EXPRESS ]   DFFA [ SEEK ]   DFFA [ MEM ]
Gene Expression Viewer (FireBrowse)DFFA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1676
GTEX Portal (Tissue expression)DFFA
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00273   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00273  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00273
Splice isoforms : SwissVarO00273
PhosPhoSitePlusO00273
Domaine pattern : Prosite (Expaxy)CIDE_N (PS51135)   
Domains : Interpro (EBI)CIDE-N_dom    DFF-C_dom    DNA_fragmentation_factor_asu    DNA_fragmentation_mid_dom   
Domain families : Pfam (Sanger)CIDE-N (PF02017)    DFF-C (PF09033)   
Domain families : Pfam (NCBI)pfam02017    pfam09033   
Domain families : Smart (EMBL)CAD (SM00266)  
Domain structure : Prodom (Prabi Lyon)DNA_fragmentation_C (PD316494)   
Conserved Domain (NCBI)DFFA
DMDM Disease mutations1676
Blocks (Seattle)DFFA
PDB (SRS)1IBX    1IYR    1KOY   
PDB (PDBSum)1IBX    1IYR    1KOY   
PDB (IMB)1IBX    1IYR    1KOY   
PDB (RSDB)1IBX    1IYR    1KOY   
Structural Biology KnowledgeBase1IBX    1IYR    1KOY   
SCOP (Structural Classification of Proteins)1IBX    1IYR    1KOY   
CATH (Classification of proteins structures)1IBX    1IYR    1KOY   
SuperfamilyO00273
Human Protein AtlasENSG00000160049
Peptide AtlasO00273
HPRD03531
IPIIPI00010882   IPI00604566   
Protein Interaction databases
DIP (DOE-UCLA)O00273
IntAct (EBI)O00273
FunCoupENSG00000160049
BioGRIDDFFA
STRING (EMBL)DFFA
ZODIACDFFA
Ontologies - Pathways
QuickGOO00273
Ontology : AmiGOnuclear chromatin  protein binding  nucleus  nucleoplasm  lipid particle  cytosol  cytosol  plasma membrane  apoptotic DNA fragmentation  protein domain specific binding  negative regulation of deoxyribonuclease activity  positive regulation of apoptotic process  protein binding involved in protein folding  deoxyribonuclease inhibitor activity  chaperone-mediated protein folding  thymocyte apoptotic process  negative regulation of execution phase of apoptosis  negative regulation of apoptotic DNA fragmentation  
Ontology : EGO-EBInuclear chromatin  protein binding  nucleus  nucleoplasm  lipid particle  cytosol  cytosol  plasma membrane  apoptotic DNA fragmentation  protein domain specific binding  negative regulation of deoxyribonuclease activity  positive regulation of apoptotic process  protein binding involved in protein folding  deoxyribonuclease inhibitor activity  chaperone-mediated protein folding  thymocyte apoptotic process  negative regulation of execution phase of apoptosis  negative regulation of apoptotic DNA fragmentation  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGApoptosis   
NDEx NetworkDFFA
Atlas of Cancer Signalling NetworkDFFA
Wikipedia pathwaysDFFA
Orthology - Evolution
OrthoDB1676
GeneTree (enSembl)ENSG00000160049
Phylogenetic Trees/Animal Genes : TreeFamDFFA
HOVERGENO00273
HOGENOMO00273
Homologs : HomoloGeneDFFA
Homology/Alignments : Family Browser (UCSC)DFFA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDFFA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DFFA
dbVarDFFA
ClinVarDFFA
1000_GenomesDFFA 
Exome Variant ServerDFFA
ExAC (Exome Aggregation Consortium)DFFA (select the gene name)
Genetic variants : HAPMAP1676
Genomic Variants (DGV)DFFA [DGVbeta]
DECIPHERDFFA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDFFA 
Mutations
ICGC Data PortalDFFA 
TCGA Data PortalDFFA 
Broad Tumor PortalDFFA
OASIS PortalDFFA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDFFA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDFFA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DFFA
DgiDB (Drug Gene Interaction Database)DFFA
DoCM (Curated mutations)DFFA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DFFA (select a term)
intoGenDFFA
Cancer3DDFFA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601882   
Orphanet
MedgenDFFA
Genetic Testing Registry DFFA
NextProtO00273 [Medical]
TSGene1676
GENETestsDFFA
Huge Navigator DFFA [HugePedia]
snp3D : Map Gene to Disease1676
BioCentury BCIQDFFA
ClinGenDFFA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1676
Chemical/Pharm GKB GenePA27254
Clinical trialDFFA
Miscellaneous
canSAR (ICR)DFFA (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDFFA
EVEXDFFA
GoPubMedDFFA
iHOPDFFA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:13:09 CEST 2017

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