Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DGAT1 (diacylglycerol O-acyltransferase 1)

Identity

Alias_namesdiacylglycerol O-acyltransferase homolog 1 (mouse)
Alias_symbol (synonym)ARGP1
DGAT
Other aliasARAT
DIAR7
HGNC (Hugo) DGAT1
LocusID (NCBI) 8694
Atlas_Id 62444
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 145538246 and ends at 145550582 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DGAT1 (8q24.3) / GLTSCR2 (19q13.33)DGAT1 (8q24.3) / TCEB1 (8q21.11)ZSWIM1 (20q13.12) / DGAT1 (8q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DGAT1   2843
Cards
Entrez_Gene (NCBI)DGAT1  8694  diacylglycerol O-acyltransferase 1
AliasesARAT; ARGP1; DGAT; DIAR7
GeneCards (Weizmann)DGAT1
Ensembl hg19 (Hinxton)ENSG00000185000 [Gene_View]  chr8:145538246-145550582 [Contig_View]  DGAT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185000 [Gene_View]  chr8:145538246-145550582 [Contig_View]  DGAT1 [Vega]
ICGC DataPortalENSG00000185000
TCGA cBioPortalDGAT1
AceView (NCBI)DGAT1
Genatlas (Paris)DGAT1
WikiGenes8694
SOURCE (Princeton)DGAT1
Genetics Home Reference (NIH)DGAT1
Genomic and cartography
GoldenPath hg19 (UCSC)DGAT1  -     chr8:145538246-145550582 -  8q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DGAT1  -     8q24.3   [Description]    (hg38-Dec_2013)
EnsemblDGAT1 - 8q24.3 [CytoView hg19]  DGAT1 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIDGAT1 [Mapview hg19]  DGAT1 [Mapview hg38]
OMIM604900   615863   
Gene and transcription
Genbank (Entrez)AB057815 AF059202 BC006263 BC015762 BC023565
RefSeq transcript (Entrez)NM_012079
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_034192 NT_008046 NW_004929341
Consensus coding sequences : CCDS (NCBI)DGAT1
Cluster EST : UnigeneHs.521954 [ NCBI ]
CGAP (NCI)Hs.521954
Alternative Splicing GalleryENSG00000185000
Gene ExpressionDGAT1 [ NCBI-GEO ]   DGAT1 [ EBI - ARRAY_EXPRESS ]   DGAT1 [ SEEK ]   DGAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)DGAT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8694
GTEX Portal (Tissue expression)DGAT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75907   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75907  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75907
Splice isoforms : SwissVarO75907
Catalytic activity : Enzyme2.3.1.20 [ Enzyme-Expasy ]   2.3.1.202.3.1.20 [ IntEnz-EBI ]   2.3.1.20 [ BRENDA ]   2.3.1.20 [ KEGG ]   
PhosPhoSitePlusO75907
Domains : Interpro (EBI)Diacylglycerol_acylTrfase1    MBOAT_fam    Oat_ACAT_DAG_ARE   
Domain families : Pfam (Sanger)MBOAT (PF03062)   
Domain families : Pfam (NCBI)pfam03062   
Conserved Domain (NCBI)DGAT1
DMDM Disease mutations8694
Blocks (Seattle)DGAT1
SuperfamilyO75907
Human Protein AtlasENSG00000185000
Peptide AtlasO75907
HPRD05360
IPIIPI00015799   IPI00982541   IPI00983140   
Protein Interaction databases
DIP (DOE-UCLA)O75907
IntAct (EBI)O75907
FunCoupENSG00000185000
BioGRIDDGAT1
STRING (EMBL)DGAT1
ZODIACDGAT1
Ontologies - Pathways
QuickGOO75907
Ontology : AmiGO2-acylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  protein binding  endoplasmic reticulum membrane  endoplasmic reticulum membrane  triglyceride metabolic process  phospholipid metabolic process  integral component of membrane  transferase activity, transferring acyl groups  triglyceride biosynthetic process  triglyceride biosynthetic process  lipid storage  very-low-density lipoprotein particle assembly  long-chain fatty-acyl-CoA metabolic process  acylglycerol acyl-chain remodeling  retinol metabolic process  cellular lipid metabolic process  small molecule metabolic process  diacylglycerol metabolic process  glycerophospholipid biosynthetic process  retinol O-fatty-acyltransferase activity  fatty acid homeostasis  
Ontology : EGO-EBI2-acylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  protein binding  endoplasmic reticulum membrane  endoplasmic reticulum membrane  triglyceride metabolic process  phospholipid metabolic process  integral component of membrane  transferase activity, transferring acyl groups  triglyceride biosynthetic process  triglyceride biosynthetic process  lipid storage  very-low-density lipoprotein particle assembly  long-chain fatty-acyl-CoA metabolic process  acylglycerol acyl-chain remodeling  retinol metabolic process  cellular lipid metabolic process  small molecule metabolic process  diacylglycerol metabolic process  glycerophospholipid biosynthetic process  retinol O-fatty-acyltransferase activity  fatty acid homeostasis  
Pathways : KEGGGlycerolipid metabolism    Retinol metabolism    Fat digestion and absorption   
NDEx NetworkDGAT1
Atlas of Cancer Signalling NetworkDGAT1
Wikipedia pathwaysDGAT1
Orthology - Evolution
OrthoDB8694
GeneTree (enSembl)ENSG00000185000
Phylogenetic Trees/Animal Genes : TreeFamDGAT1
HOVERGENO75907
HOGENOMO75907
Homologs : HomoloGeneDGAT1
Homology/Alignments : Family Browser (UCSC)DGAT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDGAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DGAT1
dbVarDGAT1
ClinVarDGAT1
1000_GenomesDGAT1 
Exome Variant ServerDGAT1
ExAC (Exome Aggregation Consortium)DGAT1 (select the gene name)
Genetic variants : HAPMAP8694
Genomic Variants (DGV)DGAT1 [DGVbeta]
DECIPHER (Syndromes)8:145538246-145550582  ENSG00000185000
CONAN: Copy Number AnalysisDGAT1 
Mutations
ICGC Data PortalDGAT1 
TCGA Data PortalDGAT1 
Broad Tumor PortalDGAT1
OASIS PortalDGAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDGAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDGAT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DGAT1
DgiDB (Drug Gene Interaction Database)DGAT1
DoCM (Curated mutations)DGAT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DGAT1 (select a term)
intoGenDGAT1
Cancer3DDGAT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604900    615863   
Orphanet21914   
MedgenDGAT1
Genetic Testing Registry DGAT1
NextProtO75907 [Medical]
TSGene8694
GENETestsDGAT1
Huge Navigator DGAT1 [HugePedia]
snp3D : Map Gene to Disease8694
BioCentury BCIQDGAT1
ClinGenDGAT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8694
Chemical/Pharm GKB GenePA27303
Clinical trialDGAT1
Miscellaneous
canSAR (ICR)DGAT1 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDGAT1
EVEXDGAT1
GoPubMedDGAT1
iHOPDGAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:01:32 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.