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DGAT2 (diacylglycerol O-acyltransferase 2)

Identity

Other aliasARAT
GS1999FULL
HMFN1045
HGNC (Hugo) DGAT2
LocusID (NCBI) 84649
Atlas_Id 57006
Location 11q13.5  [Link to chromosome band 11q13]
Location_base_pair Starts at 75768733 and ends at 75801536 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DGAT2 (11q13.5) / DOCK4 (7q31.1)DGAT2 (11q13.5) / TMBIM6 (12q13.12)UVRAG (11q13.5) / DGAT2 (11q13.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DGAT2   16940
Cards
Entrez_Gene (NCBI)DGAT2  84649  diacylglycerol O-acyltransferase 2
AliasesARAT; GS1999FULL; HMFN1045
GeneCards (Weizmann)DGAT2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr11:75768733-75801536 [Contig_View]  DGAT2 [Vega]
TCGA cBioPortalDGAT2
AceView (NCBI)DGAT2
Genatlas (Paris)DGAT2
WikiGenes84649
SOURCE (Princeton)DGAT2
Genetics Home Reference (NIH)DGAT2
Genomic and cartography
GoldenPath hg38 (UCSC)DGAT2  -     chr11:75768733-75801536 +  11q13.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DGAT2  -     11q13.5   [Description]    (hg19-Feb_2009)
EnsemblDGAT2 - 11q13.5 [CytoView hg19]  DGAT2 - 11q13.5 [CytoView hg38]
Mapping of homologs : NCBIDGAT2 [Mapview hg19]  DGAT2 [Mapview hg38]
OMIM606983   
Gene and transcription
Genbank (Entrez)AB048286 AB073384 AF384161 AI126704 AK074203
RefSeq transcript (Entrez)NM_001253891 NM_032564
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DGAT2
Cluster EST : UnigeneHs.129798 [ NCBI ]
CGAP (NCI)Hs.129798
Gene ExpressionDGAT2 [ NCBI-GEO ]   DGAT2 [ EBI - ARRAY_EXPRESS ]   DGAT2 [ SEEK ]   DGAT2 [ MEM ]
Gene Expression Viewer (FireBrowse)DGAT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84649
GTEX Portal (Tissue expression)DGAT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PD7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PD7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PD7
Splice isoforms : SwissVarQ96PD7
Catalytic activity : Enzyme2.3.1.20 [ Enzyme-Expasy ]   2.3.1.202.3.1.20 [ IntEnz-EBI ]   2.3.1.20 [ BRENDA ]   2.3.1.20 [ KEGG ]   
PhosPhoSitePlusQ96PD7
Domains : Interpro (EBI)DAGAT   
Domain families : Pfam (Sanger)DAGAT (PF03982)   
Domain families : Pfam (NCBI)pfam03982   
Conserved Domain (NCBI)DGAT2
DMDM Disease mutations84649
Blocks (Seattle)DGAT2
SuperfamilyQ96PD7
Peptide AtlasQ96PD7
IPIIPI00176376   IPI00478401   IPI00980162   IPI00981324   IPI00981810   
Protein Interaction databases
DIP (DOE-UCLA)Q96PD7
IntAct (EBI)Q96PD7
BioGRIDDGAT2
STRING (EMBL)DGAT2
ZODIACDGAT2
Ontologies - Pathways
QuickGOQ96PD7
Ontology : AmiGO2-acylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  lipid droplet  glycerol metabolic process  positive regulation of triglyceride biosynthetic process  integral component of membrane  triglyceride biosynthetic process  triglyceride biosynthetic process  triglyceride biosynthetic process  lipid storage  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  low-density lipoprotein particle clearance  long-chain fatty-acyl-CoA metabolic process  cellular triglyceride homeostasis  acylglycerol acyl-chain remodeling  retinol metabolic process  cholesterol homeostasis  protein homodimerization activity  positive regulation of gluconeogenesis  negative regulation of fatty acid oxidation  diacylglycerol metabolic process  perinuclear region of cytoplasm  retinol O-fatty-acyltransferase activity  regulation of lipoprotein metabolic process  fatty acid homeostasis  fat pad development  cellular response to oleic acid  regulation of cholesterol metabolic process  regulation of plasma lipoprotein particle levels  
Ontology : EGO-EBI2-acylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  diacylglycerol O-acyltransferase activity  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  lipid droplet  glycerol metabolic process  positive regulation of triglyceride biosynthetic process  integral component of membrane  triglyceride biosynthetic process  triglyceride biosynthetic process  triglyceride biosynthetic process  lipid storage  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  low-density lipoprotein particle clearance  long-chain fatty-acyl-CoA metabolic process  cellular triglyceride homeostasis  acylglycerol acyl-chain remodeling  retinol metabolic process  cholesterol homeostasis  protein homodimerization activity  positive regulation of gluconeogenesis  negative regulation of fatty acid oxidation  diacylglycerol metabolic process  perinuclear region of cytoplasm  retinol O-fatty-acyltransferase activity  regulation of lipoprotein metabolic process  fatty acid homeostasis  fat pad development  cellular response to oleic acid  regulation of cholesterol metabolic process  regulation of plasma lipoprotein particle levels  
Pathways : KEGGGlycerolipid metabolism    Fat digestion and absorption   
NDEx NetworkDGAT2
Atlas of Cancer Signalling NetworkDGAT2
Wikipedia pathwaysDGAT2
Orthology - Evolution
OrthoDB84649
Phylogenetic Trees/Animal Genes : TreeFamDGAT2
HOVERGENQ96PD7
HOGENOMQ96PD7
Homologs : HomoloGeneDGAT2
Homology/Alignments : Family Browser (UCSC)DGAT2
Gene fusions - Rearrangements
Tumor Fusion PortalDGAT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDGAT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DGAT2
dbVarDGAT2
ClinVarDGAT2
1000_GenomesDGAT2 
Exome Variant ServerDGAT2
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP84649
Genomic Variants (DGV)DGAT2 [DGVbeta]
DECIPHERDGAT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDGAT2 
Mutations
ICGC Data PortalDGAT2 
TCGA Data PortalDGAT2 
Broad Tumor PortalDGAT2
OASIS PortalDGAT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDGAT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDGAT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DGAT2
DgiDB (Drug Gene Interaction Database)DGAT2
DoCM (Curated mutations)DGAT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DGAT2 (select a term)
intoGenDGAT2
Cancer3DDGAT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606983   
Orphanet
DisGeNETDGAT2
MedgenDGAT2
Genetic Testing Registry DGAT2
NextProtQ96PD7 [Medical]
TSGene84649
GENETestsDGAT2
Target ValidationDGAT2
Huge Navigator DGAT2 [HugePedia]
snp3D : Map Gene to Disease84649
BioCentury BCIQDGAT2
ClinGenDGAT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84649
Chemical/Pharm GKB GenePA27304
Clinical trialDGAT2
Miscellaneous
canSAR (ICR)DGAT2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDGAT2
EVEXDGAT2
GoPubMedDGAT2
iHOPDGAT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:10:27 CET 2017

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