DGCR8 (DGCR8 microprocessor complex subunit)

2013-01-01  

Identity

HGNC
DGCR8
LOCATION
22q11.21
LOCUSID
54487
ALIAS
C22orf12,DGCRK6,Gy1,pasha
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54487
MIM: 609030
HGNC: 2847
Ensembl: ENSG00000128191

Variants:

dbSNP: 54487
ClinVar: 54487
TCGA: ENSG00000128191
COSMIC: DGCR8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128191ENST00000351989Q8WYQ5
ENSG00000128191ENST00000383024Q8WYQ5
ENSG00000128191ENST00000407755Q8WYQ5
ENSG00000128191ENST00000457069C9JSD5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927

References

Pubmed IDYearTitleCitations
155745892004The Drosha-DGCR8 complex in primary microRNA processing.692
167510992006Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.567
155891612004The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.305
191358902009Posttranscriptional crossregulation between Drosha and DGCR8.180
197214322010Schizophrenia is associated with an increase in cortical microRNA biogenesis.155
227969652012DGCR8 HITS-CLIP reveals novel functions for the Microprocessor.110
171599942007Heme is involved in microRNA processing.108
190471282008Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.99
260277392015Functional Anatomy of the Human Microprocessor.96
191389932008Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.95

Citation

Dessen P

DGCR8 (DGCR8 microprocessor complex subunit)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53138/dgcr8