Identity
HGNC
LOCATION
7p21.2
LOCUSID
ALIAS
DAGK2,DGK,DGK-BETA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1607
MIM: 604070
HGNC: 2850
Ensembl: ENSG00000136267
Variants:
dbSNP: 1607
ClinVar: 1607
TCGA: ENSG00000136267
COSMIC: DGKB
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406954 | Weight gain | Disease | ClinicalAnnotation | associated | PD | 31447353 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD | 31447353 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36603576 | 2023 | DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma. | 5 |
| 36603576 | 2023 | DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma. | 5 |
| 34944458 | 2021 | RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth. | 0 |
| 34944458 | 2021 | RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth. | 0 |
| 30242153 | 2018 | Discovering human diabetes-risk gene function with genetics and physiological assays. | 33 |
| 30242153 | 2018 | Discovering human diabetes-risk gene function with genetics and physiological assays. | 33 |
| 27839966 | 2017 | Single nucleotide polymorphisms of the DGKB and VCAM1 genes are associated with granulocyte colony stimulating factor-mediated peripheral blood stem cell mobilization. | 4 |
| 27839966 | 2017 | Single nucleotide polymorphisms of the DGKB and VCAM1 genes are associated with granulocyte colony stimulating factor-mediated peripheral blood stem cell mobilization. | 4 |
| 24695318 | 2014 | Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ. | 4 |
| 24695318 | 2014 | Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ. | 4 |
| 23814057 | 2013 | Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation. | 18 |
| 23814057 | 2013 | Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation. | 18 |
| 20889853 | 2011 | Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms. | 75 |
| 21493725 | 2011 | Diacylglycerol lipase-alpha and -beta control neurite outgrowth in neuro-2a cells through distinct molecular mechanisms. | 18 |
| 20889853 | 2011 | Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms. | 75 |
Citation
Dessen P
DGKB (diacylglycerol kinase beta)
Atlas Genet Cytogenet Oncol Haematol. 2012-11-01
Online version: http://atlasgeneticsoncology.org/gene/52993/dgkb
