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DGKD (diacylglycerol kinase delta)

Identity

Alias_namesdiacylglycerol kinase, delta (130kD)
diacylglycerol kinase, delta 130kDa
Alias_symbol (synonym)KIAA0145
DGKdelta
Other aliasdgkd-2
HGNC (Hugo) DGKD
LocusID (NCBI) 8527
Atlas_Id 54253
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233388154 and ends at 233472097 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRD9 (5p15.33) / DGKD (2q37.1)CDKN2B (9p21.3) / DGKD (2q37.1)DGKD (2q37.1) / ATG16L1 (2q37.1)
DGKD (2q37.1) / SAG (2q37.1)DGKD (2q37.1) / SP140 (2q37.1)DGKD (2q37.1) / SPP2 (2q37.1)
CDKN2B 9p21.3 / DGKD 2q37.1DGKD 2q37.1 / ATG16L1 2q37.1DGKD 2q37.1 / SAG 2q37.1
DGKD 2q37.1 / SP140 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DGKD   2851
Cards
Entrez_Gene (NCBI)DGKD  8527  diacylglycerol kinase delta
AliasesDGKdelta; dgkd-2
GeneCards (Weizmann)DGKD
Ensembl hg19 (Hinxton)ENSG00000077044 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077044 [Gene_View]  chr2:233388154-233472097 [Contig_View]  DGKD [Vega]
ICGC DataPortalENSG00000077044
TCGA cBioPortalDGKD
AceView (NCBI)DGKD
Genatlas (Paris)DGKD
WikiGenes8527
SOURCE (Princeton)DGKD
Genetics Home Reference (NIH)DGKD
Genomic and cartography
GoldenPath hg38 (UCSC)DGKD  -     chr2:233388154-233472097 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DGKD  -     2q37.1   [Description]    (hg19-Feb_2009)
EnsemblDGKD - 2q37.1 [CytoView hg19]  DGKD - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIDGKD [Mapview hg19]  DGKD [Mapview hg38]
OMIM601826   
Gene and transcription
Genbank (Entrez)AB078966 AK130440 AK307426 AK308846 AK311044
RefSeq transcript (Entrez)NM_003648 NM_152879
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DGKD
Cluster EST : UnigeneHs.471675 [ NCBI ]
CGAP (NCI)Hs.471675
Alternative Splicing GalleryENSG00000077044
Gene ExpressionDGKD [ NCBI-GEO ]   DGKD [ EBI - ARRAY_EXPRESS ]   DGKD [ SEEK ]   DGKD [ MEM ]
Gene Expression Viewer (FireBrowse)DGKD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8527
GTEX Portal (Tissue expression)DGKD
Human Protein AtlasENSG00000077044-DGKD [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16760   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16760  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16760
Splice isoforms : SwissVarQ16760
Catalytic activity : Enzyme2.7.1.107 [ Enzyme-Expasy ]   2.7.1.1072.7.1.107 [ IntEnz-EBI ]   2.7.1.107 [ BRENDA ]   2.7.1.107 [ KEGG ]   
PhosPhoSitePlusQ16760
Domaine pattern : Prosite (Expaxy)DAGK (PS50146)    PH_DOMAIN (PS50003)    SAM_DOMAIN (PS50105)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)Diacylglycerol_kin_accessory    Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase    PE/DAG-bd    PH_dom-like    PH_domain    SAM    SAM/pointed   
Domain families : Pfam (Sanger)C1_1 (PF00130)    DAGK_acc (PF00609)    DAGK_cat (PF00781)    PH (PF00169)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam00130    pfam00609    pfam00781    pfam00169    pfam07647   
Domain families : Smart (EMBL)C1 (SM00109)  DAGKa (SM00045)  DAGKc (SM00046)  PH (SM00233)  SAM (SM00454)  
Conserved Domain (NCBI)DGKD
DMDM Disease mutations8527
Blocks (Seattle)DGKD
PDB (SRS)1R79    3BQ7   
PDB (PDBSum)1R79    3BQ7   
PDB (IMB)1R79    3BQ7   
PDB (RSDB)1R79    3BQ7   
Structural Biology KnowledgeBase1R79    3BQ7   
SCOP (Structural Classification of Proteins)1R79    3BQ7   
CATH (Classification of proteins structures)1R79    3BQ7   
SuperfamilyQ16760
Human Protein Atlas [tissue]ENSG00000077044-DGKD [tissue]
Peptide AtlasQ16760
HPRD03492
IPIIPI00303136   IPI00374804   IPI00442567   IPI00979443   IPI00852951   IPI00917740   IPI00917242   
Protein Interaction databases
DIP (DOE-UCLA)Q16760
IntAct (EBI)Q16760
FunCoupENSG00000077044
BioGRIDDGKD
STRING (EMBL)DGKD
ZODIACDGKD
Ontologies - Pathways
QuickGOQ16760
Ontology : AmiGONAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  endocytosis  signal transduction  epidermal growth factor receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  multicellular organism development  response to organic substance  protein transport  cell growth  second-messenger-mediated signaling  diacylglycerol binding  platelet activation  protein homodimerization activity  diacylglycerol metabolic process  diacylglycerol metabolic process  lipid phosphorylation  metal ion binding  protein heterodimerization activity  protein homooligomerization  
Ontology : EGO-EBINAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  endocytosis  signal transduction  epidermal growth factor receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  multicellular organism development  response to organic substance  protein transport  cell growth  second-messenger-mediated signaling  diacylglycerol binding  platelet activation  protein homodimerization activity  diacylglycerol metabolic process  diacylglycerol metabolic process  lipid phosphorylation  metal ion binding  protein heterodimerization activity  protein homooligomerization  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism    Phosphatidylinositol signaling system   
NDEx NetworkDGKD
Atlas of Cancer Signalling NetworkDGKD
Wikipedia pathwaysDGKD
Orthology - Evolution
OrthoDB8527
GeneTree (enSembl)ENSG00000077044
Phylogenetic Trees/Animal Genes : TreeFamDGKD
HOVERGENQ16760
HOGENOMQ16760
Homologs : HomoloGeneDGKD
Homology/Alignments : Family Browser (UCSC)DGKD
Gene fusions - Rearrangements
Fusion : MitelmanCDKN2B/DGKD [9p21.3/2q37.1]  [t(2;9)(q37;p21)]  
Fusion : MitelmanDGKD/ATG16L1 [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion : MitelmanDGKD/SAG [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion : MitelmanDGKD/SP140 [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion : MitelmanDGKD/SPP2 [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion: TCGA_MDACCCDKN2B 9p21.3 DGKD 2q37.1 GBM
Fusion: TCGA_MDACCDGKD 2q37.1 ATG16L1 2q37.1 LUSC
Fusion: TCGA_MDACCDGKD 2q37.1 SAG 2q37.1 LUAD
Fusion: TCGA_MDACCDGKD 2q37.1 SP140 2q37.1 BRCA
Tumor Fusion PortalDGKD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDGKD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DGKD
dbVarDGKD
ClinVarDGKD
1000_GenomesDGKD 
Exome Variant ServerDGKD
ExAC (Exome Aggregation Consortium)ENSG00000077044
GNOMAD BrowserENSG00000077044
Genetic variants : HAPMAP8527
Genomic Variants (DGV)DGKD [DGVbeta]
DECIPHERDGKD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDGKD 
Mutations
ICGC Data PortalDGKD 
TCGA Data PortalDGKD 
Broad Tumor PortalDGKD
OASIS PortalDGKD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDGKD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDGKD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DGKD
DgiDB (Drug Gene Interaction Database)DGKD
DoCM (Curated mutations)DGKD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DGKD (select a term)
intoGenDGKD
Cancer3DDGKD(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601826   
Orphanet
DisGeNETDGKD
MedgenDGKD
Genetic Testing Registry DGKD
NextProtQ16760 [Medical]
TSGene8527
GENETestsDGKD
Target ValidationDGKD
Huge Navigator DGKD [HugePedia]
snp3D : Map Gene to Disease8527
BioCentury BCIQDGKD
ClinGenDGKD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8527
Chemical/Pharm GKB GenePA27312
Clinical trialDGKD
Miscellaneous
canSAR (ICR)DGKD (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDGKD
EVEXDGKD
GoPubMedDGKD
iHOPDGKD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Nov 20 20:33:56 CET 2017

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