DGKD (diacylglycerol kinase delta)

2014-08-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
DGK-delta,DGKdelta,dgkd-2
FUSION GENES

Other Information

Locus ID:

NCBI: 8527
MIM: 601826
HGNC: 2851
Ensembl: ENSG00000077044

Variants:

dbSNP: 8527
ClinVar: 8527
TCGA: ENSG00000077044
COSMIC: DGKD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077044ENST00000264057Q16760
ENSG00000077044ENST00000409813Q16760
ENSG00000077044ENST00000409813A0A024R495
ENSG00000077044ENST00000427930C9JY42
ENSG00000077044ENST00000430834H7BZR7
ENSG00000077044ENST00000442524A0A096LNI6
ENSG00000077044ENST00000447484H7C0L1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Phosphatidylinositol signaling systemKEGGko04070
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182670702008Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.81
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
183342132008Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1.31
122004422002Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions.29
173570842007Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.15
152283842004The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain.14
200649312010Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8.10
208579262010Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ.10
231849572013Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2).5
281990872017Expression, Purification, and Properties of a Human Arachidonoyl-Specific Isoform of Diacylglycerol Kinase.5

Citation

Dessen P

DGKD (diacylglycerol kinase delta)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54253/dgkd