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DGKE (diacylglycerol kinase epsilon)

Identity

Alias_namesdiacylglycerol kinase, epsilon (64kD)
diacylglycerol kinase, epsilon 64kDa
Alias_symbol (synonym)DAGK6
DGK
Other aliasAHUS7
DAGK5
NPHS7
HGNC (Hugo) DGKE
LocusID (NCBI) 8526
Atlas_Id 46638
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 56834099 and ends at 56868675 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DGKE (17q22) / EPN3 (17q21.33)DGKE (17q22) / KRT222 (17q21.2)DGKE 17q22 / EPN3 17q21.33
DGKE 17q22 / KRT222 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DGKE   2852
Cards
Entrez_Gene (NCBI)DGKE  8526  diacylglycerol kinase epsilon
AliasesAHUS7; DAGK5; DAGK6; DGK; 
NPHS7
GeneCards (Weizmann)DGKE
Ensembl hg19 (Hinxton)ENSG00000153933 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153933 [Gene_View]  chr17:56834099-56868675 [Contig_View]  DGKE [Vega]
ICGC DataPortalENSG00000153933
TCGA cBioPortalDGKE
AceView (NCBI)DGKE
Genatlas (Paris)DGKE
WikiGenes8526
SOURCE (Princeton)DGKE
Genetics Home Reference (NIH)DGKE
Genomic and cartography
GoldenPath hg38 (UCSC)DGKE  -     chr17:56834099-56868675 +  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DGKE  -     17q22   [Description]    (hg19-Feb_2009)
EnsemblDGKE - 17q22 [CytoView hg19]  DGKE - 17q22 [CytoView hg38]
Mapping of homologs : NCBIDGKE [Mapview hg19]  DGKE [Mapview hg38]
OMIM601440   615008   
Gene and transcription
Genbank (Entrez)AB209365 AK057591 AK129803 AK293039 AK310668
RefSeq transcript (Entrez)NM_003647
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DGKE
Cluster EST : UnigeneHs.239514 [ NCBI ]
CGAP (NCI)Hs.239514
Alternative Splicing GalleryENSG00000153933
Gene ExpressionDGKE [ NCBI-GEO ]   DGKE [ EBI - ARRAY_EXPRESS ]   DGKE [ SEEK ]   DGKE [ MEM ]
Gene Expression Viewer (FireBrowse)DGKE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8526
GTEX Portal (Tissue expression)DGKE
Human Protein AtlasENSG00000153933-DGKE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52429   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52429  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52429
Splice isoforms : SwissVarP52429
Catalytic activity : Enzyme2.7.1.107 [ Enzyme-Expasy ]   2.7.1.1072.7.1.107 [ IntEnz-EBI ]   2.7.1.107 [ BRENDA ]   2.7.1.107 [ KEGG ]   
PhosPhoSitePlusP52429
Domaine pattern : Prosite (Expaxy)DAGK (PS50146)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)Diacylglycerol_kin_accessory    Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase    PE/DAG-bd   
Domain families : Pfam (Sanger)C1_1 (PF00130)    DAGK_acc (PF00609)    DAGK_cat (PF00781)   
Domain families : Pfam (NCBI)pfam00130    pfam00609    pfam00781   
Domain families : Smart (EMBL)C1 (SM00109)  DAGKa (SM00045)  DAGKc (SM00046)  
Conserved Domain (NCBI)DGKE
DMDM Disease mutations8526
Blocks (Seattle)DGKE
SuperfamilyP52429
Human Protein Atlas [tissue]ENSG00000153933-DGKE [tissue]
Peptide AtlasP52429
HPRD03259
IPIIPI00003293   IPI00382834   
Protein Interaction databases
DIP (DOE-UCLA)P52429
IntAct (EBI)P52429
FunCoupENSG00000153933
BioGRIDDGKE
STRING (EMBL)DGKE
ZODIACDGKE
Ontologies - Pathways
QuickGOP52429
Ontology : AmiGONAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  protein kinase C-activating G-protein coupled receptor signaling pathway  phospholipid biosynthetic process  membrane  integral component of membrane  kinase activity  platelet activation  intracellular signal transduction  lipid phosphorylation  metal ion binding  
Ontology : EGO-EBINAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  protein kinase C-activating G-protein coupled receptor signaling pathway  phospholipid biosynthetic process  membrane  integral component of membrane  kinase activity  platelet activation  intracellular signal transduction  lipid phosphorylation  metal ion binding  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism    Phosphatidylinositol signaling system   
NDEx NetworkDGKE
Atlas of Cancer Signalling NetworkDGKE
Wikipedia pathwaysDGKE
Orthology - Evolution
OrthoDB8526
GeneTree (enSembl)ENSG00000153933
Phylogenetic Trees/Animal Genes : TreeFamDGKE
HOVERGENP52429
HOGENOMP52429
Homologs : HomoloGeneDGKE
Homology/Alignments : Family Browser (UCSC)DGKE
Gene fusions - Rearrangements
Fusion : MitelmanDGKE/EPN3 [17q22/17q21.33]  
Fusion : MitelmanDGKE/KRT222 [17q22/17q21.2]  [t(17;17)(q21;q22)]  
Fusion: TCGA_MDACCDGKE 17q22 EPN3 17q21.33 LUSC
Fusion: TCGA_MDACCDGKE 17q22 KRT222 17q21.2 BRCA
Tumor Fusion PortalDGKE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDGKE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DGKE
dbVarDGKE
ClinVarDGKE
1000_GenomesDGKE 
Exome Variant ServerDGKE
ExAC (Exome Aggregation Consortium)ENSG00000153933
GNOMAD BrowserENSG00000153933
Genetic variants : HAPMAP8526
Genomic Variants (DGV)DGKE [DGVbeta]
DECIPHERDGKE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDGKE 
Mutations
ICGC Data PortalDGKE 
TCGA Data PortalDGKE 
Broad Tumor PortalDGKE
OASIS PortalDGKE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDGKE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDGKE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DGKE
DgiDB (Drug Gene Interaction Database)DGKE
DoCM (Curated mutations)DGKE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DGKE (select a term)
intoGenDGKE
Cancer3DDGKE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601440    615008   
Orphanet21946    22195   
DisGeNETDGKE
MedgenDGKE
Genetic Testing Registry DGKE
NextProtP52429 [Medical]
TSGene8526
GENETestsDGKE
Target ValidationDGKE
Huge Navigator DGKE [HugePedia]
snp3D : Map Gene to Disease8526
BioCentury BCIQDGKE
ClinGenDGKE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8526
Chemical/Pharm GKB GenePA27313
Clinical trialDGKE
Miscellaneous
canSAR (ICR)DGKE (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDGKE
EVEXDGKE
GoPubMedDGKE
iHOPDGKE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:10:28 CET 2017

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