DGKG (diacylglycerol kinase gamma)

2003-11-01  

Identity

HGNC
LOCATION
3q27.2
LOCUSID
ALIAS
DAGK3,DGK-GAMMA
FUSION GENES

Other Information

Locus ID:

NCBI: 1608
MIM: 601854
HGNC: 2853
Ensembl: ENSG00000058866

Variants:

dbSNP: 1608
ClinVar: 1608
TCGA: ENSG00000058866
COSMIC: DGKG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058866ENST00000265022P49619
ENSG00000058866ENST00000344484P49619
ENSG00000058866ENST00000382164P49619
ENSG00000058866ENST00000437018H7C0L0

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Phosphatidylinositol signaling systemKEGGko04070
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202153972010Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.44
208161952010Analyses of shared genetic factors between asthma and obesity in children.43
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.7
282184732017Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer.7
178034612008Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin.5
303993722018Diacylglycerol kinase γ predicts prognosis and functions as a tumor suppressor by negatively regulating glucose transporter 1 in hepatocellular carcinoma.3
127322022003Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells.2
244865432014Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference.2

Citation

Dessen P

DGKG (diacylglycerol kinase gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40300/dgkg