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DGKI (diacylglycerol kinase iota)

Identity

Alias_symbol (synonym)DGK-IOTA
Other alias
HGNC (Hugo) DGKI
LocusID (NCBI) 9162
Atlas_Id 62457
Location 7q33  [Link to chromosome band 7q33]
Location_base_pair Starts at 137387650 and ends at 137846864 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC152 (5p12) / DGKI (7q33)COMMD10 (5q23.1) / DGKI (7q33)DGKI (7q33) / RAPGEF4 (2q31.1)
DGKI (7q33) / RBFOX1 (16p13.3)SP140 (2q37.1) / DGKI (7q33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DGKI   2855
Cards
Entrez_Gene (NCBI)DGKI  9162  diacylglycerol kinase iota
AliasesDGK-IOTA
GeneCards (Weizmann)DGKI
Ensembl hg19 (Hinxton)ENSG00000157680 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157680 [Gene_View]  chr7:137387650-137846864 [Contig_View]  DGKI [Vega]
ICGC DataPortalENSG00000157680
TCGA cBioPortalDGKI
AceView (NCBI)DGKI
Genatlas (Paris)DGKI
WikiGenes9162
SOURCE (Princeton)DGKI
Genetics Home Reference (NIH)DGKI
Genomic and cartography
GoldenPath hg38 (UCSC)DGKI  -     chr7:137387650-137846864 -  7q33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DGKI  -     7q33   [Description]    (hg19-Feb_2009)
EnsemblDGKI - 7q33 [CytoView hg19]  DGKI - 7q33 [CytoView hg38]
Mapping of homologs : NCBIDGKI [Mapview hg19]  DGKI [Mapview hg38]
OMIM604072   
Gene and transcription
Genbank (Entrez)AB209167 AK091081 AW237608 BC169212 DA696180
RefSeq transcript (Entrez)NM_001321708 NM_001321709 NM_001321710 NM_004717
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DGKI
Cluster EST : UnigeneHs.713106 [ NCBI ]
CGAP (NCI)Hs.713106
Alternative Splicing GalleryENSG00000157680
Gene ExpressionDGKI [ NCBI-GEO ]   DGKI [ EBI - ARRAY_EXPRESS ]   DGKI [ SEEK ]   DGKI [ MEM ]
Gene Expression Viewer (FireBrowse)DGKI [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9162
GTEX Portal (Tissue expression)DGKI
Human Protein AtlasENSG00000157680-DGKI [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75912   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75912  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75912
Splice isoforms : SwissVarO75912
Catalytic activity : Enzyme2.7.1.107 [ Enzyme-Expasy ]   2.7.1.1072.7.1.107 [ IntEnz-EBI ]   2.7.1.107 [ BRENDA ]   2.7.1.107 [ KEGG ]   
PhosPhoSitePlusO75912
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    DAGK (PS50146)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Diacylglycerol_kin_accessory    Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase    PE/DAG-bd   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    C1_1 (PF00130)    DAGK_acc (PF00609)    DAGK_cat (PF00781)   
Domain families : Pfam (NCBI)pfam12796    pfam00130    pfam00609    pfam00781   
Domain families : Smart (EMBL)ANK (SM00248)  C1 (SM00109)  DAGKa (SM00045)  DAGKc (SM00046)  
Conserved Domain (NCBI)DGKI
DMDM Disease mutations9162
Blocks (Seattle)DGKI
SuperfamilyO75912
Human Protein Atlas [tissue]ENSG00000157680-DGKI [tissue]
Peptide AtlasO75912
HPRD07238
IPIIPI00027380   IPI00847800   IPI00927461   IPI00927601   
Protein Interaction databases
DIP (DOE-UCLA)O75912
IntAct (EBI)O75912
FunCoupENSG00000157680
BioGRIDDGKI
STRING (EMBL)DGKI
ZODIACDGKI
Ontologies - Pathways
QuickGOO75912
Ontology : AmiGONAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  GTPase inhibitor activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  protein kinase C-activating G-protein coupled receptor signaling pathway  neurotransmitter secretion  synaptic vesicle  postsynaptic density  Ras GTPase binding  platelet activation  guanyl-nucleotide exchange factor complex  negative regulation of GTPase activity  intracellular signal transduction  neuronal cell body  dendritic spine  protein complex  axon terminus  synapse  positive regulation of Ras protein signal transduction  lipid phosphorylation  metal ion binding  habituation  perinuclear region of cytoplasm  presynaptic active zone  regulation of synaptic transmission, glutamatergic  excitatory synapse  excitatory postsynaptic potential  synaptic membrane  regulation of long term synaptic depression  
Ontology : EGO-EBINAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  GTPase inhibitor activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  protein kinase C-activating G-protein coupled receptor signaling pathway  neurotransmitter secretion  synaptic vesicle  postsynaptic density  Ras GTPase binding  platelet activation  guanyl-nucleotide exchange factor complex  negative regulation of GTPase activity  intracellular signal transduction  neuronal cell body  dendritic spine  protein complex  axon terminus  synapse  positive regulation of Ras protein signal transduction  lipid phosphorylation  metal ion binding  habituation  perinuclear region of cytoplasm  presynaptic active zone  regulation of synaptic transmission, glutamatergic  excitatory synapse  excitatory postsynaptic potential  synaptic membrane  regulation of long term synaptic depression  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism    Phosphatidylinositol signaling system   
NDEx NetworkDGKI
Atlas of Cancer Signalling NetworkDGKI
Wikipedia pathwaysDGKI
Orthology - Evolution
OrthoDB9162
GeneTree (enSembl)ENSG00000157680
Phylogenetic Trees/Animal Genes : TreeFamDGKI
HOVERGENO75912
HOGENOMO75912
Homologs : HomoloGeneDGKI
Homology/Alignments : Family Browser (UCSC)DGKI
Gene fusions - Rearrangements
Tumor Fusion PortalDGKI
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDGKI [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DGKI
dbVarDGKI
ClinVarDGKI
1000_GenomesDGKI 
Exome Variant ServerDGKI
ExAC (Exome Aggregation Consortium)ENSG00000157680
GNOMAD BrowserENSG00000157680
Genetic variants : HAPMAP9162
Genomic Variants (DGV)DGKI [DGVbeta]
DECIPHERDGKI [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDGKI 
Mutations
ICGC Data PortalDGKI 
TCGA Data PortalDGKI 
Broad Tumor PortalDGKI
OASIS PortalDGKI [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDGKI  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDGKI
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DGKI
DgiDB (Drug Gene Interaction Database)DGKI
DoCM (Curated mutations)DGKI (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DGKI (select a term)
intoGenDGKI
Cancer3DDGKI(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604072   
Orphanet
DisGeNETDGKI
MedgenDGKI
Genetic Testing Registry DGKI
NextProtO75912 [Medical]
TSGene9162
GENETestsDGKI
Target ValidationDGKI
Huge Navigator DGKI [HugePedia]
snp3D : Map Gene to Disease9162
BioCentury BCIQDGKI
ClinGenDGKI
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9162
Chemical/Pharm GKB GenePA27316
Clinical trialDGKI
Miscellaneous
canSAR (ICR)DGKI (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDGKI
EVEXDGKI
GoPubMedDGKI
iHOPDGKI
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:15:57 CET 2017

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