Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DGKQ (diacylglycerol kinase theta)

Identity

Alias_namesDAGK4
diacylglycerol kinase, theta (110kD)
diacylglycerol kinase, theta 110kDa
Alias_symbol (synonym)DAGK
DAGK7
Other alias
HGNC (Hugo) DGKQ
LocusID (NCBI) 1609
Atlas_Id 40301
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 958884 and ends at 973560 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DGKQ   2856
Cards
Entrez_Gene (NCBI)DGKQ  1609  diacylglycerol kinase theta
AliasesDAGK; DAGK4; DAGK7
GeneCards (Weizmann)DGKQ
Ensembl hg19 (Hinxton)ENSG00000145214 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145214 [Gene_View]  chr4:958884-973560 [Contig_View]  DGKQ [Vega]
ICGC DataPortalENSG00000145214
TCGA cBioPortalDGKQ
AceView (NCBI)DGKQ
Genatlas (Paris)DGKQ
WikiGenes1609
SOURCE (Princeton)DGKQ
Genetics Home Reference (NIH)DGKQ
Genomic and cartography
GoldenPath hg38 (UCSC)DGKQ  -     chr4:958884-973560 -  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DGKQ  -     4p16.3   [Description]    (hg19-Feb_2009)
EnsemblDGKQ - 4p16.3 [CytoView hg19]  DGKQ - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBIDGKQ [Mapview hg19]  DGKQ [Mapview hg38]
OMIM601207   
Gene and transcription
Genbank (Entrez)AB209503 AW139889 BC063801 DN990411 DQ596864
RefSeq transcript (Entrez)NM_001347
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DGKQ
Cluster EST : UnigeneHs.584858 [ NCBI ]
CGAP (NCI)Hs.584858
Alternative Splicing GalleryENSG00000145214
Gene ExpressionDGKQ [ NCBI-GEO ]   DGKQ [ EBI - ARRAY_EXPRESS ]   DGKQ [ SEEK ]   DGKQ [ MEM ]
Gene Expression Viewer (FireBrowse)DGKQ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1609
GTEX Portal (Tissue expression)DGKQ
Human Protein AtlasENSG00000145214-DGKQ [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52824   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52824  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52824
Splice isoforms : SwissVarP52824
Catalytic activity : Enzyme2.7.1.107 [ Enzyme-Expasy ]   2.7.1.1072.7.1.107 [ IntEnz-EBI ]   2.7.1.107 [ BRENDA ]   2.7.1.107 [ KEGG ]   
PhosPhoSitePlusP52824
Domaine pattern : Prosite (Expaxy)DAGK (PS50146)    RA (PS50200)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)Diacylglycerol_kin_accessory    Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase    PE/DAG-bd    RA_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)C1_1 (PF00130)    DAGK_acc (PF00609)    DAGK_cat (PF00781)    RA (PF00788)   
Domain families : Pfam (NCBI)pfam00130    pfam00609    pfam00781    pfam00788   
Domain families : Smart (EMBL)C1 (SM00109)  DAGKa (SM00045)  DAGKc (SM00046)  RA (SM00314)  
Conserved Domain (NCBI)DGKQ
DMDM Disease mutations1609
Blocks (Seattle)DGKQ
SuperfamilyP52824
Human Protein Atlas [tissue]ENSG00000145214-DGKQ [tissue]
Peptide AtlasP52824
HPRD03127
IPIIPI00005565   IPI00964305   IPI00967525   IPI00966764   
Protein Interaction databases
DIP (DOE-UCLA)P52824
IntAct (EBI)P52824
FunCoupENSG00000145214
BioGRIDDGKQ
STRING (EMBL)DGKQ
ZODIACDGKQ
Ontologies - Pathways
QuickGOP52824
Ontology : AmiGONAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  cytoplasm  endosome  cytosol  cytoskeleton  plasma membrane  plasma membrane  regulation of gluconeogenesis  regulation of transcription from RNA polymerase II promoter  phosphatidic acid biosynthetic process  phosphatidic acid biosynthetic process  activation of transmembrane receptor protein tyrosine kinase activity  G-protein coupled receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  positive regulation of gene expression  negative regulation of gene expression  negative regulation of peptidyl-threonine phosphorylation  negative regulation of peptidyl-threonine phosphorylation  vesicle membrane  nuclear matrix  nuclear speck  peptidyl-serine phosphorylation  kinase binding  cAMP-mediated signaling  cAMP-mediated signaling  platelet activation  transmembrane receptor protein tyrosine kinase activator activity  response to ATP  activating transcription factor binding  phospholipase binding  diacylglycerol metabolic process  glycerolipid metabolic process  lipid phosphorylation  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  response to cAMP  thrombin-activated receptor signaling pathway  protein kinase C signaling  regulation of cholesterol metabolic process  regulation of TORC1 signaling  regulation of cortisol biosynthetic process  regulation of progesterone biosynthetic process  
Ontology : EGO-EBINAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  cytoplasm  endosome  cytosol  cytoskeleton  plasma membrane  plasma membrane  regulation of gluconeogenesis  regulation of transcription from RNA polymerase II promoter  phosphatidic acid biosynthetic process  phosphatidic acid biosynthetic process  activation of transmembrane receptor protein tyrosine kinase activity  G-protein coupled receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  positive regulation of gene expression  negative regulation of gene expression  negative regulation of peptidyl-threonine phosphorylation  negative regulation of peptidyl-threonine phosphorylation  vesicle membrane  nuclear matrix  nuclear speck  peptidyl-serine phosphorylation  kinase binding  cAMP-mediated signaling  cAMP-mediated signaling  platelet activation  transmembrane receptor protein tyrosine kinase activator activity  response to ATP  activating transcription factor binding  phospholipase binding  diacylglycerol metabolic process  glycerolipid metabolic process  lipid phosphorylation  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  response to cAMP  thrombin-activated receptor signaling pathway  protein kinase C signaling  regulation of cholesterol metabolic process  regulation of TORC1 signaling  regulation of cortisol biosynthetic process  regulation of progesterone biosynthetic process  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism    Phosphatidylinositol signaling system   
NDEx NetworkDGKQ
Atlas of Cancer Signalling NetworkDGKQ
Wikipedia pathwaysDGKQ
Orthology - Evolution
OrthoDB1609
GeneTree (enSembl)ENSG00000145214
Phylogenetic Trees/Animal Genes : TreeFamDGKQ
HOVERGENP52824
HOGENOMP52824
Homologs : HomoloGeneDGKQ
Homology/Alignments : Family Browser (UCSC)DGKQ
Gene fusions - Rearrangements
Tumor Fusion PortalDGKQ
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDGKQ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DGKQ
dbVarDGKQ
ClinVarDGKQ
1000_GenomesDGKQ 
Exome Variant ServerDGKQ
ExAC (Exome Aggregation Consortium)ENSG00000145214
GNOMAD BrowserENSG00000145214
Genetic variants : HAPMAP1609
Genomic Variants (DGV)DGKQ [DGVbeta]
DECIPHERDGKQ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDGKQ 
Mutations
ICGC Data PortalDGKQ 
TCGA Data PortalDGKQ 
Broad Tumor PortalDGKQ
OASIS PortalDGKQ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDGKQ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDGKQ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DGKQ
DgiDB (Drug Gene Interaction Database)DGKQ
DoCM (Curated mutations)DGKQ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DGKQ (select a term)
intoGenDGKQ
Cancer3DDGKQ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601207   
Orphanet
DisGeNETDGKQ
MedgenDGKQ
Genetic Testing Registry DGKQ
NextProtP52824 [Medical]
TSGene1609
GENETestsDGKQ
Target ValidationDGKQ
Huge Navigator DGKQ [HugePedia]
snp3D : Map Gene to Disease1609
BioCentury BCIQDGKQ
ClinGenDGKQ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1609
Chemical/Pharm GKB GenePA27317
Clinical trialDGKQ
Miscellaneous
canSAR (ICR)DGKQ (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDGKQ
EVEXDGKQ
GoPubMedDGKQ
iHOPDGKQ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:10:28 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.