DGKQ (diacylglycerol kinase theta)

2003-11-01  

Identity

HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
DAGK,DAGK4,DAGK7

Other Information

Locus ID:

NCBI: 1609
MIM: 601207
HGNC: 2856
Ensembl: ENSG00000145214

Variants:

dbSNP: 1609
ClinVar: 1609
TCGA: ENSG00000145214
COSMIC: DGKQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145214ENST00000273814P52824
ENSG00000145214ENST00000273814A0A140VKC1
ENSG00000145214ENST00000509465H0YA20
ENSG00000145214ENST00000510286D6RJB4
ENSG00000145214ENST00000515182H0Y8Q7

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Phosphatidylinositol signaling systemKEGGko04070
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
156321892005Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.27
176642812007Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.26
127991902003Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus.21
237679592013Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes.10
230910602012Dual regulation of diacylglycerol kinase (DGK)-θ: polybasic proteins promote activation by phospholipids and increase substrate affinity.8
236101602013cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1.8
243691172014Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells.6
227321452012Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.5
236186832013GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population.0

Citation

Dessen P

DGKQ (diacylglycerol kinase theta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40301/dgkq