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DGKZ (diacylglycerol kinase zeta)

Identity

Alias_namesdiacylglycerol kinase
Alias_symbol (synonym)DAGK5
hDGKzeta
DGK-ZETA
DAGK6
Other alias
HGNC (Hugo) DGKZ
LocusID (NCBI) 8525
Atlas_Id 46580
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 46383145 and ends at 46402104 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DGKZ (11p11.2) / DGKZ (11p11.2)DGKZ (11p11.2) / PCSK7 (11q23.3)DGKZ (11p11.2) / RAB6B (3q22.1)
MEG3 (14q32.2) / DGKZ (11p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DGKZ   2857
Cards
Entrez_Gene (NCBI)DGKZ  8525  diacylglycerol kinase zeta
AliasesDAGK5; DAGK6; DGK-ZETA; hDGKzeta
GeneCards (Weizmann)DGKZ
Ensembl hg19 (Hinxton)ENSG00000149091 [Gene_View]  chr11:46383145-46402104 [Contig_View]  DGKZ [Vega]
Ensembl hg38 (Hinxton)ENSG00000149091 [Gene_View]  chr11:46383145-46402104 [Contig_View]  DGKZ [Vega]
ICGC DataPortalENSG00000149091
TCGA cBioPortalDGKZ
AceView (NCBI)DGKZ
Genatlas (Paris)DGKZ
WikiGenes8525
SOURCE (Princeton)DGKZ
Genetics Home Reference (NIH)DGKZ
Genomic and cartography
GoldenPath hg19 (UCSC)DGKZ  -     chr11:46383145-46402104 +  11p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DGKZ  -     11p11.2   [Description]    (hg38-Dec_2013)
EnsemblDGKZ - 11p11.2 [CytoView hg19]  DGKZ - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIDGKZ [Mapview hg19]  DGKZ [Mapview hg38]
OMIM601441   
Gene and transcription
Genbank (Entrez)AB209635 AK097960 AK123378 AK124594 AK124693
RefSeq transcript (Entrez)NM_001105540 NM_001199266 NM_001199267 NM_001199268 NM_003646 NM_201532 NM_201533
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)DGKZ
Cluster EST : UnigeneHs.502461 [ NCBI ]
CGAP (NCI)Hs.502461
Alternative Splicing GalleryENSG00000149091
Gene ExpressionDGKZ [ NCBI-GEO ]   DGKZ [ EBI - ARRAY_EXPRESS ]   DGKZ [ SEEK ]   DGKZ [ MEM ]
Gene Expression Viewer (FireBrowse)DGKZ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8525
GTEX Portal (Tissue expression)DGKZ
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13574   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13574  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13574
Splice isoforms : SwissVarQ13574
Catalytic activity : Enzyme2.7.1.107 [ Enzyme-Expasy ]   2.7.1.1072.7.1.107 [ IntEnz-EBI ]   2.7.1.107 [ BRENDA ]   2.7.1.107 [ KEGG ]   
PhosPhoSitePlusQ13574
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    DAGK (PS50146)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Diacylglycerol_kin_accessory    Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase    PE/DAG-bd   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    C1_1 (PF00130)    DAGK_acc (PF00609)    DAGK_cat (PF00781)   
Domain families : Pfam (NCBI)pfam12796    pfam00130    pfam00609    pfam00781   
Domain families : Smart (EMBL)ANK (SM00248)  C1 (SM00109)  DAGKa (SM00045)  DAGKc (SM00046)  
Conserved Domain (NCBI)DGKZ
DMDM Disease mutations8525
Blocks (Seattle)DGKZ
SuperfamilyQ13574
Human Protein AtlasENSG00000149091
Peptide AtlasQ13574
HPRD03260
IPIIPI00013835   IPI00983918   IPI00556127   IPI00922452   IPI00816295   IPI00446667   IPI00977628   IPI00867551   IPI00398065   IPI00978041   IPI00976044   IPI01013344   IPI00977036   IPI00984494   IPI00300125   
Protein Interaction databases
DIP (DOE-UCLA)Q13574
IntAct (EBI)Q13574
FunCoupENSG00000149091
BioGRIDDGKZ
STRING (EMBL)DGKZ
ZODIACDGKZ
Ontologies - Pathways
QuickGOQ13574
Ontology : AmiGOlipid kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  plasma membrane  protein kinase C-activating G-protein coupled receptor signaling pathway  protein C-terminus binding  phosphorylation  phosphorylation  cell migration  lamellipodium  platelet activation  mitotic G1 DNA damage checkpoint  intracellular signal transduction  negative regulation of mitotic cell cycle  lipid phosphorylation  metal ion binding  
Ontology : EGO-EBIlipid kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  plasma membrane  protein kinase C-activating G-protein coupled receptor signaling pathway  protein C-terminus binding  phosphorylation  phosphorylation  cell migration  lamellipodium  platelet activation  mitotic G1 DNA damage checkpoint  intracellular signal transduction  negative regulation of mitotic cell cycle  lipid phosphorylation  metal ion binding  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism    Phosphatidylinositol signaling system   
NDEx NetworkDGKZ
Atlas of Cancer Signalling NetworkDGKZ
Wikipedia pathwaysDGKZ
Orthology - Evolution
OrthoDB8525
GeneTree (enSembl)ENSG00000149091
Phylogenetic Trees/Animal Genes : TreeFamDGKZ
HOVERGENQ13574
HOGENOMQ13574
Homologs : HomoloGeneDGKZ
Homology/Alignments : Family Browser (UCSC)DGKZ
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDGKZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DGKZ
dbVarDGKZ
ClinVarDGKZ
1000_GenomesDGKZ 
Exome Variant ServerDGKZ
ExAC (Exome Aggregation Consortium)DGKZ (select the gene name)
Genetic variants : HAPMAP8525
Genomic Variants (DGV)DGKZ [DGVbeta]
DECIPHER (Syndromes)11:46383145-46402104  ENSG00000149091
CONAN: Copy Number AnalysisDGKZ 
Mutations
ICGC Data PortalDGKZ 
TCGA Data PortalDGKZ 
Broad Tumor PortalDGKZ
OASIS PortalDGKZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDGKZ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDGKZ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DGKZ
DgiDB (Drug Gene Interaction Database)DGKZ
DoCM (Curated mutations)DGKZ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DGKZ (select a term)
intoGenDGKZ
Cancer3DDGKZ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601441   
Orphanet
MedgenDGKZ
Genetic Testing Registry DGKZ
NextProtQ13574 [Medical]
TSGene8525
GENETestsDGKZ
Huge Navigator DGKZ [HugePedia]
snp3D : Map Gene to Disease8525
BioCentury BCIQDGKZ
ClinGenDGKZ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8525
Chemical/Pharm GKB GenePA27318
Clinical trialDGKZ
Miscellaneous
canSAR (ICR)DGKZ (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDGKZ
EVEXDGKZ
GoPubMedDGKZ
iHOPDGKZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:03:11 CET 2017

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