Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DGKZ (diacylglycerol kinase zeta)

Identity

Alias_namesdiacylglycerol kinase
Alias_symbol (synonym)DAGK5
hDGKzeta
DGK-ZETA
DAGK6
Other alias
HGNC (Hugo) DGKZ
LocusID (NCBI) 8525
Atlas_Id 46580
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 46345267 and ends at 46380554 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DGKZ (11p11.2) / DGKZ (11p11.2)DGKZ (11p11.2) / PCSK7 (11q23.3)DGKZ (11p11.2) / RAB6B (3q22.1)
MEG3 (14q32.2) / DGKZ (11p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DGKZ   2857
Cards
Entrez_Gene (NCBI)DGKZ  8525  diacylglycerol kinase zeta
AliasesDAGK5; DAGK6; DGK-ZETA; hDGKzeta
GeneCards (Weizmann)DGKZ
Ensembl hg19 (Hinxton)ENSG00000149091 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149091 [Gene_View]  ENSG00000149091 [Sequence]  chr11:46345267-46380554 [Contig_View]  DGKZ [Vega]
ICGC DataPortalENSG00000149091
TCGA cBioPortalDGKZ
AceView (NCBI)DGKZ
Genatlas (Paris)DGKZ
WikiGenes8525
SOURCE (Princeton)DGKZ
Genetics Home Reference (NIH)DGKZ
Genomic and cartography
GoldenPath hg38 (UCSC)DGKZ  -     chr11:46345267-46380554 +  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DGKZ  -     11p11.2   [Description]    (hg19-Feb_2009)
EnsemblDGKZ - 11p11.2 [CytoView hg19]  DGKZ - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIDGKZ [Mapview hg19]  DGKZ [Mapview hg38]
OMIM601441   
Gene and transcription
Genbank (Entrez)AB209635 AK097960 AK123378 AK124594 AK124693
RefSeq transcript (Entrez)NM_001105540 NM_001199266 NM_001199267 NM_001199268 NM_003646 NM_201532 NM_201533
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DGKZ
Cluster EST : UnigeneHs.502461 [ NCBI ]
CGAP (NCI)Hs.502461
Alternative Splicing GalleryENSG00000149091
Gene ExpressionDGKZ [ NCBI-GEO ]   DGKZ [ EBI - ARRAY_EXPRESS ]   DGKZ [ SEEK ]   DGKZ [ MEM ]
Gene Expression Viewer (FireBrowse)DGKZ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8525
GTEX Portal (Tissue expression)DGKZ
Human Protein AtlasENSG00000149091-DGKZ [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13574   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13574  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13574
Splice isoforms : SwissVarQ13574
Catalytic activity : Enzyme2.7.1.107 [ Enzyme-Expasy ]   2.7.1.1072.7.1.107 [ IntEnz-EBI ]   2.7.1.107 [ BRENDA ]   2.7.1.107 [ KEGG ]   
PhosPhoSitePlusQ13574
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    DAGK (PS50146)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    ATP-NAD_kinase_N    DGK    Diacylglycerol_kin_accessory    Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase_sf    PE/DAG-bd   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    C1_1 (PF00130)    DAGK_acc (PF00609)    DAGK_cat (PF00781)   
Domain families : Pfam (NCBI)pfam12796    pfam00130    pfam00609    pfam00781   
Domain families : Smart (EMBL)ANK (SM00248)  C1 (SM00109)  DAGKa (SM00045)  DAGKc (SM00046)  
Conserved Domain (NCBI)DGKZ
DMDM Disease mutations8525
Blocks (Seattle)DGKZ
PDB (SRS)5ELQ   
PDB (PDBSum)5ELQ   
PDB (IMB)5ELQ   
PDB (RSDB)5ELQ   
Structural Biology KnowledgeBase5ELQ   
SCOP (Structural Classification of Proteins)5ELQ   
CATH (Classification of proteins structures)5ELQ   
SuperfamilyQ13574
Human Protein Atlas [tissue]ENSG00000149091-DGKZ [tissue]
Peptide AtlasQ13574
HPRD03260
IPIIPI00013835   IPI00983918   IPI00556127   IPI00922452   IPI00816295   IPI00446667   IPI00977628   IPI00867551   IPI00398065   IPI00978041   IPI00976044   IPI01013344   IPI00977036   IPI00984494   IPI00300125   
Protein Interaction databases
DIP (DOE-UCLA)Q13574
IntAct (EBI)Q13574
FunCoupENSG00000149091
BioGRIDDGKZ
STRING (EMBL)DGKZ
ZODIACDGKZ
Ontologies - Pathways
QuickGOQ13574
Ontology : AmiGONAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  cytoplasm  plasma membrane  protein kinase C-activating G-protein coupled receptor signaling pathway  kinase activity  cell migration  nuclear speck  lamellipodium  platelet activation  intracellular signal transduction  diacylglycerol metabolic process  glycerolipid metabolic process  lipid phosphorylation  metal ion binding  
Ontology : EGO-EBINAD+ kinase activity  diacylglycerol kinase activity  diacylglycerol kinase activity  protein binding  ATP binding  nucleus  cytoplasm  plasma membrane  protein kinase C-activating G-protein coupled receptor signaling pathway  kinase activity  cell migration  nuclear speck  lamellipodium  platelet activation  intracellular signal transduction  diacylglycerol metabolic process  glycerolipid metabolic process  lipid phosphorylation  metal ion binding  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism    Phosphatidylinositol signaling system   
NDEx NetworkDGKZ
Atlas of Cancer Signalling NetworkDGKZ
Wikipedia pathwaysDGKZ
Orthology - Evolution
OrthoDB8525
GeneTree (enSembl)ENSG00000149091
Phylogenetic Trees/Animal Genes : TreeFamDGKZ
HOVERGENQ13574
HOGENOMQ13574
Homologs : HomoloGeneDGKZ
Homology/Alignments : Family Browser (UCSC)DGKZ
Gene fusions - Rearrangements
Fusion : QuiverDGKZ
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDGKZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DGKZ
dbVarDGKZ
ClinVarDGKZ
1000_GenomesDGKZ 
Exome Variant ServerDGKZ
ExAC (Exome Aggregation Consortium)ENSG00000149091
GNOMAD BrowserENSG00000149091
Varsome BrowserDGKZ
Genetic variants : HAPMAP8525
Genomic Variants (DGV)DGKZ [DGVbeta]
DECIPHERDGKZ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDGKZ 
Mutations
ICGC Data PortalDGKZ 
TCGA Data PortalDGKZ 
Broad Tumor PortalDGKZ
OASIS PortalDGKZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDGKZ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDGKZ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DGKZ
DgiDB (Drug Gene Interaction Database)DGKZ
DoCM (Curated mutations)DGKZ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DGKZ (select a term)
intoGenDGKZ
Cancer3DDGKZ(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601441   
Orphanet
DisGeNETDGKZ
MedgenDGKZ
Genetic Testing Registry DGKZ
NextProtQ13574 [Medical]
TSGene8525
GENETestsDGKZ
Target ValidationDGKZ
Huge Navigator DGKZ [HugePedia]
snp3D : Map Gene to Disease8525
BioCentury BCIQDGKZ
ClinGenDGKZ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8525
Chemical/Pharm GKB GenePA27318
Clinical trialDGKZ
Miscellaneous
canSAR (ICR)DGKZ (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDGKZ
EVEXDGKZ
GoPubMedDGKZ
iHOPDGKZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:19:08 CEST 2018
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