DGKZ (diacylglycerol kinase zeta)

2007-02-01 Affiliation

Identity

HGNC

DGKZ

LOCATION

11p11.2

LOCUSID

8525

ALIAS

DAGK5,DAGK6,DGK-ZETA,hDGKzeta

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8525
MIM: 601441
HGNC: 2857
Ensembl: ENSG00000149091

Variants:

dbSNP: 8525
ClinVar: 8525
TCGA: ENSG00000149091
COSMIC: DGKZ

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000149091	ENST00000318201	Q13574
ENSG00000149091	ENST00000343674	Q13574
ENSG00000149091	ENST00000421244	Q13574
ENSG00000149091	ENST00000454345	Q13574
ENSG00000149091	ENST00000456247	Q13574
ENSG00000149091	ENST00000524448	H0YEG2
ENSG00000149091	ENST00000524869	H0YDN6
ENSG00000149091	ENST00000524984	E9PNZ3
ENSG00000149091	ENST00000525242	E9PKT3
ENSG00000149091	ENST00000527911	Q13574
ENSG00000149091	ENST00000528615	E9PNL8
ENSG00000149091	ENST00000532868	Q13574
ENSG00000149091	ENST00000533376	E9PK94

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerolipid metabolism	KEGG	ko00561
Glycerophospholipid metabolism	KEGG	ko00564
Phosphatidylinositol signaling system	KEGG	ko04070
Glycerolipid metabolism	KEGG	hsa00561
Glycerophospholipid metabolism	KEGG	hsa00564
Phosphatidylinositol signaling system	KEGG	hsa04070
Metabolic pathways	KEGG	hsa01100
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Effects of PIP2 hydrolysis	REACTOME	R-HSA-114508
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15632115	2005	Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid.	48
12070163	2002	Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.	42
19211846	2009	Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.	42
12890670	2003	Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta.	28
15157668	2004	Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism.	23
22271650	2012	Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.	21
25921290	2015	Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions.	20
21937721	2011	Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.	19
12015310	2002	Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity.	17
14707140	2004	Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src.	14

Citation

Dessen P

DGKZ (diacylglycerol kinase zeta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46580/dgkz